Challenges in drug discovery for thiazolidinedione substitute
Thiazolidinedione (TZD) is a powerful insulin sensitizer in the treatment of type 2 diabetes. It acts as a ligand to the nuclear receptor PPARγ (peroxisome proliferator-activated receptor-gamma) and induces transcription of PPARγ-responsive genes. TZD controls lipid synthesis and storage in adipose...
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| Format: | Article |
| Language: | English |
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Elsevier
2011-10-01
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| Series: | Acta Pharmaceutica Sinica B |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383511000505 |