Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice.
Regular consumption of food enriched in omega3 polyunsaturated fatty acids (ω3 PUFAs) has been shown to reduce risk of cognitive decline in elderly, and possibly development of Alzheimer's disease. Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are the most likely active components...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2012-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3360741?pdf=render |
| _version_ | 1818945926571491328 |
|---|---|
| author | Virginie F Labrousse Agnès Nadjar Corinne Joffre Laurence Costes Agnès Aubert Stéphane Grégoire Lionel Bretillon Sophie Layé |
| author_facet | Virginie F Labrousse Agnès Nadjar Corinne Joffre Laurence Costes Agnès Aubert Stéphane Grégoire Lionel Bretillon Sophie Layé |
| author_sort | Virginie F Labrousse |
| collection | DOAJ |
| description | Regular consumption of food enriched in omega3 polyunsaturated fatty acids (ω3 PUFAs) has been shown to reduce risk of cognitive decline in elderly, and possibly development of Alzheimer's disease. Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are the most likely active components of ω3-rich PUFAs diets in the brain. We therefore hypothesized that exposing mice to a DHA and EPA enriched diet may reduce neuroinflammation and protect against memory impairment in aged mice. For this purpose, mice were exposed to a control diet throughout life and were further submitted to a diet enriched in EPA and DHA during 2 additional months. Cytokine expression together with a thorough analysis of astrocytes morphology assessed by a 3D reconstruction was measured in the hippocampus of young (3-month-old) and aged (22-month-old) mice. In addition, the effects of EPA and DHA on spatial memory and associated Fos activation in the hippocampus were assessed. We showed that a 2-month EPA/DHA treatment increased these long-chain ω3 PUFAs in the brain, prevented cytokines expression and astrocytes morphology changes in the hippocampus and restored spatial memory deficits and Fos-associated activation in the hippocampus of aged mice. Collectively, these data indicated that diet-induced accumulation of EPA and DHA in the brain protects against neuroinflammation and cognitive impairment linked to aging, further reinforcing the idea that increased EPA and DHA intake may provide protection to the brain of aged subjects. |
| first_indexed | 2024-12-20T08:06:53Z |
| format | Article |
| id | doaj.art-1a01484e22cb42b09e302a1eae572577 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T08:06:53Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1a01484e22cb42b09e302a1eae5725772022-12-21T19:47:23ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0175e3686110.1371/journal.pone.0036861Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice.Virginie F LabrousseAgnès NadjarCorinne JoffreLaurence CostesAgnès AubertStéphane GrégoireLionel BretillonSophie LayéRegular consumption of food enriched in omega3 polyunsaturated fatty acids (ω3 PUFAs) has been shown to reduce risk of cognitive decline in elderly, and possibly development of Alzheimer's disease. Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are the most likely active components of ω3-rich PUFAs diets in the brain. We therefore hypothesized that exposing mice to a DHA and EPA enriched diet may reduce neuroinflammation and protect against memory impairment in aged mice. For this purpose, mice were exposed to a control diet throughout life and were further submitted to a diet enriched in EPA and DHA during 2 additional months. Cytokine expression together with a thorough analysis of astrocytes morphology assessed by a 3D reconstruction was measured in the hippocampus of young (3-month-old) and aged (22-month-old) mice. In addition, the effects of EPA and DHA on spatial memory and associated Fos activation in the hippocampus were assessed. We showed that a 2-month EPA/DHA treatment increased these long-chain ω3 PUFAs in the brain, prevented cytokines expression and astrocytes morphology changes in the hippocampus and restored spatial memory deficits and Fos-associated activation in the hippocampus of aged mice. Collectively, these data indicated that diet-induced accumulation of EPA and DHA in the brain protects against neuroinflammation and cognitive impairment linked to aging, further reinforcing the idea that increased EPA and DHA intake may provide protection to the brain of aged subjects.http://europepmc.org/articles/PMC3360741?pdf=render |
| spellingShingle | Virginie F Labrousse Agnès Nadjar Corinne Joffre Laurence Costes Agnès Aubert Stéphane Grégoire Lionel Bretillon Sophie Layé Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice. PLoS ONE |
| title | Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice. |
| title_full | Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice. |
| title_fullStr | Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice. |
| title_full_unstemmed | Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice. |
| title_short | Short-term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice. |
| title_sort | short term long chain omega3 diet protects from neuroinflammatory processes and memory impairment in aged mice |
| url | http://europepmc.org/articles/PMC3360741?pdf=render |
| work_keys_str_mv | AT virginieflabrousse shorttermlongchainomega3dietprotectsfromneuroinflammatoryprocessesandmemoryimpairmentinagedmice AT agnesnadjar shorttermlongchainomega3dietprotectsfromneuroinflammatoryprocessesandmemoryimpairmentinagedmice AT corinnejoffre shorttermlongchainomega3dietprotectsfromneuroinflammatoryprocessesandmemoryimpairmentinagedmice AT laurencecostes shorttermlongchainomega3dietprotectsfromneuroinflammatoryprocessesandmemoryimpairmentinagedmice AT agnesaubert shorttermlongchainomega3dietprotectsfromneuroinflammatoryprocessesandmemoryimpairmentinagedmice AT stephanegregoire shorttermlongchainomega3dietprotectsfromneuroinflammatoryprocessesandmemoryimpairmentinagedmice AT lionelbretillon shorttermlongchainomega3dietprotectsfromneuroinflammatoryprocessesandmemoryimpairmentinagedmice AT sophielaye shorttermlongchainomega3dietprotectsfromneuroinflammatoryprocessesandmemoryimpairmentinagedmice |