Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview
In-tube solid phase microextraction is a cutting-edge sample treatment technique offering significant advantages in terms of miniaturization, green character, automation, and preconcentration prior to analysis. During the past years, there has been a considerable increase in the reported publication...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/9/2096 |
| _version_ | 1827717704273887232 |
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| author | Natalia Manousi Paraskevas D. Tzanavaras Constantinos K. Zacharis |
| author_facet | Natalia Manousi Paraskevas D. Tzanavaras Constantinos K. Zacharis |
| author_sort | Natalia Manousi |
| collection | DOAJ |
| description | In-tube solid phase microextraction is a cutting-edge sample treatment technique offering significant advantages in terms of miniaturization, green character, automation, and preconcentration prior to analysis. During the past years, there has been a considerable increase in the reported publications, as well as in the research groups focusing their activities on this technique. In the present review article, HPLC bioanalytical applications of in-tube SPME are discussed, covering a wide time frame of twenty years of research reports. Instrumental aspects towards the coupling of in-tube SPME and HPLC are also discussed, and detailed information on materials/coatings and applications in biological samples are provided. |
| first_indexed | 2024-03-10T20:08:08Z |
| format | Article |
| id | doaj.art-1a030c7cb3a44eabb57d1b7d35dce2d1 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T20:08:08Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1a030c7cb3a44eabb57d1b7d35dce2d12023-11-19T23:07:08ZengMDPI AGMolecules1420-30492020-04-01259209610.3390/molecules25092096Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade OverviewNatalia Manousi0Paraskevas D. Tzanavaras1Constantinos K. Zacharis2Laboratory of Analytical Chemistry, School of Chemistry, Faculty of Sciences, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, GreeceLaboratory of Analytical Chemistry, School of Chemistry, Faculty of Sciences, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, GreeceLaboratory of Pharmaceutical Analysis, Department of Pharmaceutical Technology, School of Pharmacy, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, GreeceIn-tube solid phase microextraction is a cutting-edge sample treatment technique offering significant advantages in terms of miniaturization, green character, automation, and preconcentration prior to analysis. During the past years, there has been a considerable increase in the reported publications, as well as in the research groups focusing their activities on this technique. In the present review article, HPLC bioanalytical applications of in-tube SPME are discussed, covering a wide time frame of twenty years of research reports. Instrumental aspects towards the coupling of in-tube SPME and HPLC are also discussed, and detailed information on materials/coatings and applications in biological samples are provided.https://www.mdpi.com/1420-3049/25/9/2096bioanalysisin-tubesolid phase microextractionseparationsample preparationreview |
| spellingShingle | Natalia Manousi Paraskevas D. Tzanavaras Constantinos K. Zacharis Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview Molecules bioanalysis in-tube solid phase microextraction separation sample preparation review |
| title | Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview |
| title_full | Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview |
| title_fullStr | Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview |
| title_full_unstemmed | Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview |
| title_short | Bioanalytical HPLC Applications of In-Tube Solid Phase Microextraction: A Two-Decade Overview |
| title_sort | bioanalytical hplc applications of in tube solid phase microextraction a two decade overview |
| topic | bioanalysis in-tube solid phase microextraction separation sample preparation review |
| url | https://www.mdpi.com/1420-3049/25/9/2096 |
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