Effect evaluation of supramolecular complex of ivermectin Aniverm-2.0% on postnatal development of rat offspring
The purpose of the research is to detect long-term effects of repeated oral administration of supramolecular complex of ivermectin Aniverm-2.0% on the postnatal development of rat offspring.Materials and methods. The studies were conducted on 16 white pregnant rats that were divided into two experim...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Federal Scientific Centre VIEV
2023-04-01
|
| Series: | Российский паразитологический журнал |
| Subjects: | |
| Online Access: | https://vniigis.elpub.ru/jour/article/view/1013 |
| _version_ | 1797270399589810176 |
|---|---|
| author | V. V. Zashchepkina M. B. Musaev |
| author_facet | V. V. Zashchepkina M. B. Musaev |
| author_sort | V. V. Zashchepkina |
| collection | DOAJ |
| description | The purpose of the research is to detect long-term effects of repeated oral administration of supramolecular complex of ivermectin Aniverm-2.0% on the postnatal development of rat offspring.Materials and methods. The studies were conducted on 16 white pregnant rats that were divided into two experimental and one control groups. The animals were kept under standard conditions of keeping and feeding. The supramolecular complex of ivermectin Aniverm-2.0% was administered to pregnant female rats (n = 6) of group 1 in the form of a suspension using an intragastric tube daily for 7 days at a dose of 15 mg/kg, and group 2 was given the substance of ivermectin (n = 5) at a dose of 8.25 mg/kg. The control female rats (n = 5) were administered 1 mL of distilled water during the experiment. The experimental pregnant females were left until delivery, and then, the development of their offspring was monitored for 45 days. After rat pups were born, the following were recorded: pregnancy duration, litter size, dynamics of weight gain in the rat pups for 21 days, postnatal death during the first 30 days, the ratio of males and females in the litter, periods of eye opening, incisor eruption, detachment of the auricle, appearance of hair coat, descent of testicles, and opening of the vagina. Then we assessed the maturation rate of sensory-motor reflexes in the offspring obtained from the experimental and control groups, the emotional motor behavior and ability for fine coordination of movements in the offspring, and conducted the open field-2 test on day 45 after birth.Results and discussion. No negative effect was detected for supramolecular complex of ivermectin Aniverm-2.0% on the parameters of physiological development of the offspring of the experimental rats within 45 days after birth. The dynamics of their mass, developmental parameters, and formation of motor reflexes during the feeding period remained within the normal values. Developmental indicators of sensory motor reflexes in the control and experimental rat pups had no statistically significant differences. |
| first_indexed | 2024-03-08T21:39:45Z |
| format | Article |
| id | doaj.art-1a052cbb761c41a5b0f3730fce4ed740 |
| institution | Directory Open Access Journal |
| issn | 1998-8435 2541-7843 |
| language | Russian |
| last_indexed | 2024-04-25T02:03:39Z |
| publishDate | 2023-04-01 |
| publisher | Federal Scientific Centre VIEV |
| record_format | Article |
| series | Российский паразитологический журнал |
| spelling | doaj.art-1a052cbb761c41a5b0f3730fce4ed7402024-03-07T14:34:32ZrusFederal Scientific Centre VIEVРоссийский паразитологический журнал1998-84352541-78432023-04-0117110511310.31016/1998-8435-2023-17-1-105-113734Effect evaluation of supramolecular complex of ivermectin Aniverm-2.0% on postnatal development of rat offspringV. V. Zashchepkina0M. B. Musaev1All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV” (VNIIP – FSC VIEV)All-Russian Scientific Research Institute for Fundamental and Applied Parasitology of Animals and Plant – a branch of the Federal State Budget Scientific Institution “Federal Scientific Centre VIEV” (VNIIP – FSC VIEV)The purpose of the research is to detect long-term effects of repeated oral administration of supramolecular complex of ivermectin Aniverm-2.0% on the postnatal development of rat offspring.Materials and methods. The studies were conducted on 16 white pregnant rats that were divided into two experimental and one control groups. The animals were kept under standard conditions of keeping and feeding. The supramolecular complex of ivermectin Aniverm-2.0% was administered to pregnant female rats (n = 6) of group 1 in the form of a suspension using an intragastric tube daily for 7 days at a dose of 15 mg/kg, and group 2 was given the substance of ivermectin (n = 5) at a dose of 8.25 mg/kg. The control female rats (n = 5) were administered 1 mL of distilled water during the experiment. The experimental pregnant females were left until delivery, and then, the development of their offspring was monitored for 45 days. After rat pups were born, the following were recorded: pregnancy duration, litter size, dynamics of weight gain in the rat pups for 21 days, postnatal death during the first 30 days, the ratio of males and females in the litter, periods of eye opening, incisor eruption, detachment of the auricle, appearance of hair coat, descent of testicles, and opening of the vagina. Then we assessed the maturation rate of sensory-motor reflexes in the offspring obtained from the experimental and control groups, the emotional motor behavior and ability for fine coordination of movements in the offspring, and conducted the open field-2 test on day 45 after birth.Results and discussion. No negative effect was detected for supramolecular complex of ivermectin Aniverm-2.0% on the parameters of physiological development of the offspring of the experimental rats within 45 days after birth. The dynamics of their mass, developmental parameters, and formation of motor reflexes during the feeding period remained within the normal values. Developmental indicators of sensory motor reflexes in the control and experimental rat pups had no statistically significant differences.https://vniigis.elpub.ru/jour/article/view/1013ratsivermectinsupramolecular complexaniverm-2.0%postnatal periodemotional motor behaviorreflexes |
| spellingShingle | V. V. Zashchepkina M. B. Musaev Effect evaluation of supramolecular complex of ivermectin Aniverm-2.0% on postnatal development of rat offspring Российский паразитологический журнал rats ivermectin supramolecular complex aniverm-2.0% postnatal period emotional motor behavior reflexes |
| title | Effect evaluation of supramolecular complex of ivermectin Aniverm-2.0% on postnatal development of rat offspring |
| title_full | Effect evaluation of supramolecular complex of ivermectin Aniverm-2.0% on postnatal development of rat offspring |
| title_fullStr | Effect evaluation of supramolecular complex of ivermectin Aniverm-2.0% on postnatal development of rat offspring |
| title_full_unstemmed | Effect evaluation of supramolecular complex of ivermectin Aniverm-2.0% on postnatal development of rat offspring |
| title_short | Effect evaluation of supramolecular complex of ivermectin Aniverm-2.0% on postnatal development of rat offspring |
| title_sort | effect evaluation of supramolecular complex of ivermectin aniverm 2 0 on postnatal development of rat offspring |
| topic | rats ivermectin supramolecular complex aniverm-2.0% postnatal period emotional motor behavior reflexes |
| url | https://vniigis.elpub.ru/jour/article/view/1013 |
| work_keys_str_mv | AT vvzashchepkina effectevaluationofsupramolecularcomplexofivermectinaniverm20onpostnataldevelopmentofratoffspring AT mbmusaev effectevaluationofsupramolecularcomplexofivermectinaniverm20onpostnataldevelopmentofratoffspring |