The Optimal Management of <i>Neisseria gonorrhoeae</i> Infections
<i>Neisseria gonorrhoeae</i> is one of the most frequent etiologic agents of STDs (sexually transmitted diseases). Untreated asymptomatic gonococcal infection in women can lead to spreading of the infection in the sexually active population and could lead to late consequences, such as st...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/12/2388 |
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| author | Ramona Gabriela Ursu Ionut Luchian Costin Damian Elena Porumb-Andrese Roxana Gabriela Cobzaru Giorgio Nichitean Carmen Ripa Diana Costin Darius Sandu Ioana-Maria Andrioaie Luminita Smaranda Iancu |
| author_facet | Ramona Gabriela Ursu Ionut Luchian Costin Damian Elena Porumb-Andrese Roxana Gabriela Cobzaru Giorgio Nichitean Carmen Ripa Diana Costin Darius Sandu Ioana-Maria Andrioaie Luminita Smaranda Iancu |
| author_sort | Ramona Gabriela Ursu |
| collection | DOAJ |
| description | <i>Neisseria gonorrhoeae</i> is one of the most frequent etiologic agents of STDs (sexually transmitted diseases). Untreated asymptomatic gonococcal infection in women can lead to spreading of the infection in the sexually active population and could lead to late consequences, such as sterility or ectopic pregnancies. One important issue about <i>N. gonorrhoeae</i> is its increasing resistance to antibiotics. This paper summarized the newest molecular antimicrobial resistance (AMR) detection assays for <i>Neisseria gonorrhoeae</i> connected with the latest therapeutic antimicrobials and gonococcal vaccine candidates. The assays used to detect AMR varied from the classical minimal inhibitory concentration (MIC) detection to whole-genome sequencing. New drugs against multi drug resistant (MDR) <i>N. gonorrhoeae</i> have been proposed and were evaluated in vivo and in vitro as being efficient in decreasing the <i>N. gonorrhoeae</i> burden. In addition, anti-<i>N. gonorrhoeae</i> vaccine candidates are being researched, which have been assessed by multiple techniques. With the efforts of many researchers who are studying the detection of antimicrobial resistance in this bacterium and identifying new drugs and new vaccine candidates against it, there is hope in reducing the gonorrhea burden worldwide. |
| first_indexed | 2024-03-09T16:03:56Z |
| format | Article |
| id | doaj.art-1a0579b620b4496c9e03263b4b5e3bfb |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T16:03:56Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-1a0579b620b4496c9e03263b4b5e3bfb2023-11-24T16:48:16ZengMDPI AGMicroorganisms2076-26072022-12-011012238810.3390/microorganisms10122388The Optimal Management of <i>Neisseria gonorrhoeae</i> InfectionsRamona Gabriela Ursu0Ionut Luchian1Costin Damian2Elena Porumb-Andrese3Roxana Gabriela Cobzaru4Giorgio Nichitean5Carmen Ripa6Diana Costin7Darius Sandu8Ioana-Maria Andrioaie9Luminita Smaranda Iancu10Department of Preventive Medicine and Interdisciplinarity (IX)—Microbiology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Periodontology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Preventive Medicine and Interdisciplinarity (IX)—Microbiology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Medical Specialties (III)-Dermatology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Preventive Medicine and Interdisciplinarity (IX)—Microbiology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFaculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Preventive Medicine and Interdisciplinarity (IX)—Microbiology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Preventive Medicine and Interdisciplinarity (IX)—Microbiology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaFaculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Preventive Medicine and Interdisciplinarity (IX)—Microbiology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Preventive Medicine and Interdisciplinarity (IX)—Microbiology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania<i>Neisseria gonorrhoeae</i> is one of the most frequent etiologic agents of STDs (sexually transmitted diseases). Untreated asymptomatic gonococcal infection in women can lead to spreading of the infection in the sexually active population and could lead to late consequences, such as sterility or ectopic pregnancies. One important issue about <i>N. gonorrhoeae</i> is its increasing resistance to antibiotics. This paper summarized the newest molecular antimicrobial resistance (AMR) detection assays for <i>Neisseria gonorrhoeae</i> connected with the latest therapeutic antimicrobials and gonococcal vaccine candidates. The assays used to detect AMR varied from the classical minimal inhibitory concentration (MIC) detection to whole-genome sequencing. New drugs against multi drug resistant (MDR) <i>N. gonorrhoeae</i> have been proposed and were evaluated in vivo and in vitro as being efficient in decreasing the <i>N. gonorrhoeae</i> burden. In addition, anti-<i>N. gonorrhoeae</i> vaccine candidates are being researched, which have been assessed by multiple techniques. With the efforts of many researchers who are studying the detection of antimicrobial resistance in this bacterium and identifying new drugs and new vaccine candidates against it, there is hope in reducing the gonorrhea burden worldwide.https://www.mdpi.com/2076-2607/10/12/2388gonococcal infectionsAMR detection assaynew drugsNG vaccine candidate |
| spellingShingle | Ramona Gabriela Ursu Ionut Luchian Costin Damian Elena Porumb-Andrese Roxana Gabriela Cobzaru Giorgio Nichitean Carmen Ripa Diana Costin Darius Sandu Ioana-Maria Andrioaie Luminita Smaranda Iancu The Optimal Management of <i>Neisseria gonorrhoeae</i> Infections Microorganisms gonococcal infections AMR detection assay new drugs NG vaccine candidate |
| title | The Optimal Management of <i>Neisseria gonorrhoeae</i> Infections |
| title_full | The Optimal Management of <i>Neisseria gonorrhoeae</i> Infections |
| title_fullStr | The Optimal Management of <i>Neisseria gonorrhoeae</i> Infections |
| title_full_unstemmed | The Optimal Management of <i>Neisseria gonorrhoeae</i> Infections |
| title_short | The Optimal Management of <i>Neisseria gonorrhoeae</i> Infections |
| title_sort | optimal management of i neisseria gonorrhoeae i infections |
| topic | gonococcal infections AMR detection assay new drugs NG vaccine candidate |
| url | https://www.mdpi.com/2076-2607/10/12/2388 |
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