Packaging signal of influenza A virus
Abstract Influenza A virus (IAV) contains a genome with eight single-stranded, negative-sense RNA segments that encode 17 proteins. During its assembly, all eight separate viral RNA (vRNA) segments are incorporated into virions in a selective manner. Evidence suggested that the highly selective geno...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | Virology Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12985-021-01504-4 |
| _version_ | 1818953319393001472 |
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| author | Xiuli Li Min Gu Qinmei Zheng Ruyi Gao Xiufan Liu |
| author_facet | Xiuli Li Min Gu Qinmei Zheng Ruyi Gao Xiufan Liu |
| author_sort | Xiuli Li |
| collection | DOAJ |
| description | Abstract Influenza A virus (IAV) contains a genome with eight single-stranded, negative-sense RNA segments that encode 17 proteins. During its assembly, all eight separate viral RNA (vRNA) segments are incorporated into virions in a selective manner. Evidence suggested that the highly selective genome packaging mechanism relies on RNA-RNA or protein-RNA interactions. The specific structures of each vRNA that contribute to mediating the packaging of the vRNA into virions have been described and identified as packaging signals. Abundant research indicated that sequences required for genome incorporation are not series and are varied among virus genotypes. The packaging signals play important roles in determining the virus replication, genome incorporation and genetic reassortment of influenza A virus. In this review, we discuss recent studies on influenza A virus packaging signals to provide an overview of their characteristics and functions. |
| first_indexed | 2024-12-20T10:04:23Z |
| format | Article |
| id | doaj.art-1a05e80d3dec4096ba2c3d2b04b4f3ff |
| institution | Directory Open Access Journal |
| issn | 1743-422X |
| language | English |
| last_indexed | 2024-12-20T10:04:23Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Virology Journal |
| spelling | doaj.art-1a05e80d3dec4096ba2c3d2b04b4f3ff2022-12-21T19:44:15ZengBMCVirology Journal1743-422X2021-02-0118111010.1186/s12985-021-01504-4Packaging signal of influenza A virusXiuli Li0Min Gu1Qinmei Zheng2Ruyi Gao3Xiufan Liu4Animal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou UniversityAnimal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou UniversityAnimal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou UniversityAnimal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou UniversityAnimal Infectious Disease Laboratory, College of Veterinary Medicine, Yangzhou UniversityAbstract Influenza A virus (IAV) contains a genome with eight single-stranded, negative-sense RNA segments that encode 17 proteins. During its assembly, all eight separate viral RNA (vRNA) segments are incorporated into virions in a selective manner. Evidence suggested that the highly selective genome packaging mechanism relies on RNA-RNA or protein-RNA interactions. The specific structures of each vRNA that contribute to mediating the packaging of the vRNA into virions have been described and identified as packaging signals. Abundant research indicated that sequences required for genome incorporation are not series and are varied among virus genotypes. The packaging signals play important roles in determining the virus replication, genome incorporation and genetic reassortment of influenza A virus. In this review, we discuss recent studies on influenza A virus packaging signals to provide an overview of their characteristics and functions.https://doi.org/10.1186/s12985-021-01504-4Influenza A virusPackaging signalsIncorporationReassortmentRNA-RNA interaction |
| spellingShingle | Xiuli Li Min Gu Qinmei Zheng Ruyi Gao Xiufan Liu Packaging signal of influenza A virus Virology Journal Influenza A virus Packaging signals Incorporation Reassortment RNA-RNA interaction |
| title | Packaging signal of influenza A virus |
| title_full | Packaging signal of influenza A virus |
| title_fullStr | Packaging signal of influenza A virus |
| title_full_unstemmed | Packaging signal of influenza A virus |
| title_short | Packaging signal of influenza A virus |
| title_sort | packaging signal of influenza a virus |
| topic | Influenza A virus Packaging signals Incorporation Reassortment RNA-RNA interaction |
| url | https://doi.org/10.1186/s12985-021-01504-4 |
| work_keys_str_mv | AT xiulili packagingsignalofinfluenzaavirus AT mingu packagingsignalofinfluenzaavirus AT qinmeizheng packagingsignalofinfluenzaavirus AT ruyigao packagingsignalofinfluenzaavirus AT xiufanliu packagingsignalofinfluenzaavirus |