Decreases in TGF-β1 and PDGF levels are associated with echocardiographic changes during adjuvant radiotherapy for breast cancer

Decreases in TGF-β1 and PDGF levels are associated with echocardiographic changes during adjuvant radiotherapy for breast cancer

Abstract Background Radiation-induced heart disease is mainly caused by activation of the fibrotic process. Transforming growth factor-beta 1 (TGF-β1) and platelet-derived growth factor (PDGF) are pro-fibrotic mediators. The aim of our study was to evaluate the behavior of TGF-β1 and PDGF during adj...

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Main Authors: Hanna Aula, Tanja Skyttä, Suvi Tuohinen, Tiina Luukkaala, Mari Hämäläinen, Vesa Virtanen, Pekka Raatikainen, Eeva Moilanen, Pirkko-Liisa Kellokumpu-Lehtinen
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Radiation Oncology
Subjects:
Cardiotoxicity
Breast cancer
Radiotherapy
Transforming growth factor beta-1
Platelet-derived growth factor
Echocardiography
Online Access:http://link.springer.com/article/10.1186/s13014-018-1150-7

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