Biotransformation profiles from a cohort of chronic fatigue women in response to a hepatic detoxification challenge.
Chronic fatigue, in its various manifestations, frequently co-occur with pain, sleep disturbances and depression and is a non-communicable condition which is rapidly becoming endemic worldwide. However, it is handicapped by a lack of objective definitions and diagnostic measures. This has prompted t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0216298 |
| _version_ | 1797661364189134848 |
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| author | Elardus Erasmus Francois E Steffens Mari van Reenen B Chris Vorster Carolus J Reinecke |
| author_facet | Elardus Erasmus Francois E Steffens Mari van Reenen B Chris Vorster Carolus J Reinecke |
| author_sort | Elardus Erasmus |
| collection | DOAJ |
| description | Chronic fatigue, in its various manifestations, frequently co-occur with pain, sleep disturbances and depression and is a non-communicable condition which is rapidly becoming endemic worldwide. However, it is handicapped by a lack of objective definitions and diagnostic measures. This has prompted the World Health Organization to develop an international instrument whose intended purpose is to improve quality of life (QOL), with energy and fatigue as one domain of focus. To complement this objective, the interface between detoxification, the exposome, and xenobiotic-sensing by nuclear receptors that mediate induction of biotransformation-linked genes, is stimulating renewed attention to a rational development of strategies to identify the metabolic profiles in complex multifactorial conditions like fatigue. Here we present results from a seven-year study of a cohort of 576 female patients suffering from low to high levels of chronic fatigue, in which phase I and phase II biotransformation was assessed. The biotransformation profiles used were based on hepatic detoxification challenge tests through oral caffeine, acetaminophen and acetylsalicylic acid ingestion coupled with oxidative stress analyses. The interventions indicated normal phase I but increased phase II glucuronidation and glycination conjugation. Complementarity was indicated between a fatigue scale, medical symptoms and associated energy-related parameters by application of Chi-square Automatic Interaction Detector (CHAID) analysis. The presented study provides a cluster of data from which we propose that multidisciplinary inputs from the combination of a fatigue scale, medical symptoms and biotransformation profiles provide the rationale for the development of a comprehensive laboratory instrument for improved diagnostics and personalized interventions in patients with chronic fatigue with a view to improving their QOL. |
| first_indexed | 2024-03-11T18:44:27Z |
| format | Article |
| id | doaj.art-1a0a2acc545941bda0e87a62d7fe7e30 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-11T18:44:27Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1a0a2acc545941bda0e87a62d7fe7e302023-10-12T05:31:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01145e021629810.1371/journal.pone.0216298Biotransformation profiles from a cohort of chronic fatigue women in response to a hepatic detoxification challenge.Elardus ErasmusFrancois E SteffensMari van ReenenB Chris VorsterCarolus J ReineckeChronic fatigue, in its various manifestations, frequently co-occur with pain, sleep disturbances and depression and is a non-communicable condition which is rapidly becoming endemic worldwide. However, it is handicapped by a lack of objective definitions and diagnostic measures. This has prompted the World Health Organization to develop an international instrument whose intended purpose is to improve quality of life (QOL), with energy and fatigue as one domain of focus. To complement this objective, the interface between detoxification, the exposome, and xenobiotic-sensing by nuclear receptors that mediate induction of biotransformation-linked genes, is stimulating renewed attention to a rational development of strategies to identify the metabolic profiles in complex multifactorial conditions like fatigue. Here we present results from a seven-year study of a cohort of 576 female patients suffering from low to high levels of chronic fatigue, in which phase I and phase II biotransformation was assessed. The biotransformation profiles used were based on hepatic detoxification challenge tests through oral caffeine, acetaminophen and acetylsalicylic acid ingestion coupled with oxidative stress analyses. The interventions indicated normal phase I but increased phase II glucuronidation and glycination conjugation. Complementarity was indicated between a fatigue scale, medical symptoms and associated energy-related parameters by application of Chi-square Automatic Interaction Detector (CHAID) analysis. The presented study provides a cluster of data from which we propose that multidisciplinary inputs from the combination of a fatigue scale, medical symptoms and biotransformation profiles provide the rationale for the development of a comprehensive laboratory instrument for improved diagnostics and personalized interventions in patients with chronic fatigue with a view to improving their QOL.https://doi.org/10.1371/journal.pone.0216298 |
| spellingShingle | Elardus Erasmus Francois E Steffens Mari van Reenen B Chris Vorster Carolus J Reinecke Biotransformation profiles from a cohort of chronic fatigue women in response to a hepatic detoxification challenge. PLoS ONE |
| title | Biotransformation profiles from a cohort of chronic fatigue women in response to a hepatic detoxification challenge. |
| title_full | Biotransformation profiles from a cohort of chronic fatigue women in response to a hepatic detoxification challenge. |
| title_fullStr | Biotransformation profiles from a cohort of chronic fatigue women in response to a hepatic detoxification challenge. |
| title_full_unstemmed | Biotransformation profiles from a cohort of chronic fatigue women in response to a hepatic detoxification challenge. |
| title_short | Biotransformation profiles from a cohort of chronic fatigue women in response to a hepatic detoxification challenge. |
| title_sort | biotransformation profiles from a cohort of chronic fatigue women in response to a hepatic detoxification challenge |
| url | https://doi.org/10.1371/journal.pone.0216298 |
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