Cefepime-induced neurotoxicity: a systematic review

Cefepime-induced neurotoxicity: a systematic review

Abstract Background Cefepime is a widely used antibiotic with neurotoxicity attributed to its ability to cross the blood–brain barrier and exhibit concentration-dependent ϒ-aminobutyric acid (GABA) antagonism. Neurotoxic symptoms include depressed consciousness, encephalopathy, aphasia, myoclonus, s...

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Bibliographic Details
Main Authors: Lauren E. Payne, David J. Gagnon, Richard R. Riker, David B. Seder, Elizabeth K. Glisic, Jane G. Morris, Gilles L. Fraser
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Critical Care
Subjects:
Adverse events
Blood–brain barrier
Cefepime
Cephalosporin
Coma
Intensive care units
Online Access:http://link.springer.com/article/10.1186/s13054-017-1856-1

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http://link.springer.com/article/10.1186/s13054-017-1856-1

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