Pegylation, as method of production prolonged forms of biopharmaceutical drugs (pegylated granulocyte colony-stimulating factor as case of study)
By now the pegylation of biologically active molecules including proteins with an inert hydrophilic polymer polyethylene glycol (PEG) is an important area in the new generation of prolonged-action pharmaceutical preparations. The conjugated molecules usually have an improved pharmacokinetic profile,...
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| Format: | Article |
| Language: | Russian |
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MIREA - Russian Technological University
2014-04-01
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| Series: | Тонкие химические технологии |
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| Online Access: | https://www.finechem-mirea.ru/jour/article/view/478 |
| _version_ | 1826565762034171904 |
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| author | I. А. Puchkov D. I. Bairamashvili V. I. Shvets |
| author_facet | I. А. Puchkov D. I. Bairamashvili V. I. Shvets |
| author_sort | I. А. Puchkov |
| collection | DOAJ |
| description | By now the pegylation of biologically active molecules including proteins with an inert hydrophilic polymer polyethylene glycol (PEG) is an important area in the new generation of prolonged-action pharmaceutical preparations. The conjugated molecules usually have an improved pharmacokinetic profile, including reduced renal clearance, additional protection from the proteolytic enzymes and reduced immunogenicity, thus preserving the in vivo activity of the native preparation in the human body for a longer time. This review is focused on the example of the pegylation of recombinant human granulocyte colony-stimulating factor (G-CSF) and gives the opportunity to have a look at different ways of pegylation and the mechanism of this reaction. Besides, the review describes the different types of reactive PEG for the specific conjugation to biological molecules and benefits and disadvantages of these reagents. |
| first_indexed | 2024-04-10T03:29:22Z |
| format | Article |
| id | doaj.art-1a0b561f8794436abf2969907ed17acb |
| institution | Directory Open Access Journal |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| last_indexed | 2025-03-14T10:40:54Z |
| publishDate | 2014-04-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj.art-1a0b561f8794436abf2969907ed17acb2025-03-02T10:57:31ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752014-04-0192331472Pegylation, as method of production prolonged forms of biopharmaceutical drugs (pegylated granulocyte colony-stimulating factor as case of study)I. А. Puchkov0D. I. Bairamashvili1V. I. Shvets2M.V. Lomonosov Moscow State University of Fine Chemical Technologies, 86, Vernadskogo pr., Moscow 119571; Russian Pharmaceutical Company «Masterclone», Moscow, 119019Test Biotechnological Production of the Genetically Engineered Preparations of M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, 117997МИТХТ им. М.В. Ломоносова, 119571, Москва, пр-т Вернадского, д. 86By now the pegylation of biologically active molecules including proteins with an inert hydrophilic polymer polyethylene glycol (PEG) is an important area in the new generation of prolonged-action pharmaceutical preparations. The conjugated molecules usually have an improved pharmacokinetic profile, including reduced renal clearance, additional protection from the proteolytic enzymes and reduced immunogenicity, thus preserving the in vivo activity of the native preparation in the human body for a longer time. This review is focused on the example of the pegylation of recombinant human granulocyte colony-stimulating factor (G-CSF) and gives the opportunity to have a look at different ways of pegylation and the mechanism of this reaction. Besides, the review describes the different types of reactive PEG for the specific conjugation to biological molecules and benefits and disadvantages of these reagents.https://www.finechem-mirea.ru/jour/article/view/478polyethylene glycol (peg), biopharmaceutical drugs, granulocyte colony-stimulating factor (g-csf), modification, cytokines, pharmacokinetic profile. |
| spellingShingle | I. А. Puchkov D. I. Bairamashvili V. I. Shvets Pegylation, as method of production prolonged forms of biopharmaceutical drugs (pegylated granulocyte colony-stimulating factor as case of study) Тонкие химические технологии polyethylene glycol (peg), biopharmaceutical drugs, granulocyte colony-stimulating factor (g-csf), modification, cytokines, pharmacokinetic profile. |
| title | Pegylation, as method of production prolonged forms of biopharmaceutical drugs (pegylated granulocyte colony-stimulating factor as case of study) |
| title_full | Pegylation, as method of production prolonged forms of biopharmaceutical drugs (pegylated granulocyte colony-stimulating factor as case of study) |
| title_fullStr | Pegylation, as method of production prolonged forms of biopharmaceutical drugs (pegylated granulocyte colony-stimulating factor as case of study) |
| title_full_unstemmed | Pegylation, as method of production prolonged forms of biopharmaceutical drugs (pegylated granulocyte colony-stimulating factor as case of study) |
| title_short | Pegylation, as method of production prolonged forms of biopharmaceutical drugs (pegylated granulocyte colony-stimulating factor as case of study) |
| title_sort | pegylation as method of production prolonged forms of biopharmaceutical drugs pegylated granulocyte colony stimulating factor as case of study |
| topic | polyethylene glycol (peg), biopharmaceutical drugs, granulocyte colony-stimulating factor (g-csf), modification, cytokines, pharmacokinetic profile. |
| url | https://www.finechem-mirea.ru/jour/article/view/478 |
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