Human umbilical cord-derived mesenchymal stem cells utilise Activin-A to suppress Interferon-gamma production by natural killer cells.

Human umbilical cord-derived mesenchymal stem cells utilise Activin-A to suppress Interferon-gamma production by natural killer cells.

Following allogeneic hematopoietic stem cell transplantation (HSCT), interferon (IFN)-gamma levels in the recipient’s body can strongly influence the clinical outcome. Human umbilical cord-derived mesenchymal stem cells (UC-MSCs) are lucrative as biological tolerance-inducers in HSCT settings. Hence...

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Bibliographic Details
Main Authors: Debanjana eChaterjee, Nicole eMarquardt, Dejene Milkessa Tufa, Tim eHatlapatka, Ralf eHass, Cornelia eKasper, Constantin evon Kaisenberg, Reinhold Ernst Schmidt, Roland eJacobs
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Immunology
Subjects:
Interferon-gamma
NK cells
Suppression
T-bet
UC-MSC
Activin-A
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00662/full

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