Preparation and Biomedical Applications of Cucurbit[n]uril-Based Supramolecular Hydrogels
The cucurbit[n]uril supramolecular hydrogels are driven by weak intermolecular interactions, of which exhibit good stimuli responsiveness and excellent self-healing properties. According to the composition of the gelling factor, supramolecular hydrogels comprise Q[n]-cross-linked small molecules and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/8/3566 |
| _version_ | 1797604075937726464 |
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| author | Ruihan Gao Qingmei Ge Hang Cong Yunqian Zhang Jianglin Zhao |
| author_facet | Ruihan Gao Qingmei Ge Hang Cong Yunqian Zhang Jianglin Zhao |
| author_sort | Ruihan Gao |
| collection | DOAJ |
| description | The cucurbit[n]uril supramolecular hydrogels are driven by weak intermolecular interactions, of which exhibit good stimuli responsiveness and excellent self-healing properties. According to the composition of the gelling factor, supramolecular hydrogels comprise Q[n]-cross-linked small molecules and Q[n]-cross-linked polymers. According to different driving forces, hydrogels are driven by the outer-surface interaction, the host–guest inclusion interaction, and the host–guest exclusion interaction. Host–guest interactions are widely used in the construction of self-healing hydrogels, which can spontaneously recover after being damaged, thereby prolonging their service life. The smart Q[n]s-based supramolecular hydrogel composed is a kind of adjustable and low-toxicity soft material. By designing the structure of the hydrogel or modifying the fluorescent properties, etc., it can be widely used in biomedicine. In this review, we mainly focus on the preparation of Q[n]-based hydrogels and their biomedical applications including cell encapsulation for biocatalysis, biosensors for high sensitivity, 3D printing for potential tissue engineering, drug release for sustained delivery, and interfacial adhesion for self-healing materials. In addition, we also presented the current challenges and prospects in this field. |
| first_indexed | 2024-03-11T04:41:12Z |
| format | Article |
| id | doaj.art-1a0debc4b9214a299eac3794100932c0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T04:41:12Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-1a0debc4b9214a299eac3794100932c02023-11-17T20:40:50ZengMDPI AGMolecules1420-30492023-04-01288356610.3390/molecules28083566Preparation and Biomedical Applications of Cucurbit[n]uril-Based Supramolecular HydrogelsRuihan Gao0Qingmei Ge1Hang Cong2Yunqian Zhang3Jianglin Zhao4Enterprise Technology Center of Guizhou Province, Guizhou University, Guiyang 550025, ChinaEnterprise Technology Center of Guizhou Province, Guizhou University, Guiyang 550025, ChinaEnterprise Technology Center of Guizhou Province, Guizhou University, Guiyang 550025, ChinaEnterprise Technology Center of Guizhou Province, Guizhou University, Guiyang 550025, ChinaPrecision Medicine R&D Center, Zhuhai Institute of Advanced Technology, Chinese Academy of Sciences, Zhuhai 519000, ChinaThe cucurbit[n]uril supramolecular hydrogels are driven by weak intermolecular interactions, of which exhibit good stimuli responsiveness and excellent self-healing properties. According to the composition of the gelling factor, supramolecular hydrogels comprise Q[n]-cross-linked small molecules and Q[n]-cross-linked polymers. According to different driving forces, hydrogels are driven by the outer-surface interaction, the host–guest inclusion interaction, and the host–guest exclusion interaction. Host–guest interactions are widely used in the construction of self-healing hydrogels, which can spontaneously recover after being damaged, thereby prolonging their service life. The smart Q[n]s-based supramolecular hydrogel composed is a kind of adjustable and low-toxicity soft material. By designing the structure of the hydrogel or modifying the fluorescent properties, etc., it can be widely used in biomedicine. In this review, we mainly focus on the preparation of Q[n]-based hydrogels and their biomedical applications including cell encapsulation for biocatalysis, biosensors for high sensitivity, 3D printing for potential tissue engineering, drug release for sustained delivery, and interfacial adhesion for self-healing materials. In addition, we also presented the current challenges and prospects in this field.https://www.mdpi.com/1420-3049/28/8/3566cucurbit[n]urilssupramolecular hydrogelsbiomedicalhost–guest interactions |
| spellingShingle | Ruihan Gao Qingmei Ge Hang Cong Yunqian Zhang Jianglin Zhao Preparation and Biomedical Applications of Cucurbit[n]uril-Based Supramolecular Hydrogels Molecules cucurbit[n]urils supramolecular hydrogels biomedical host–guest interactions |
| title | Preparation and Biomedical Applications of Cucurbit[n]uril-Based Supramolecular Hydrogels |
| title_full | Preparation and Biomedical Applications of Cucurbit[n]uril-Based Supramolecular Hydrogels |
| title_fullStr | Preparation and Biomedical Applications of Cucurbit[n]uril-Based Supramolecular Hydrogels |
| title_full_unstemmed | Preparation and Biomedical Applications of Cucurbit[n]uril-Based Supramolecular Hydrogels |
| title_short | Preparation and Biomedical Applications of Cucurbit[n]uril-Based Supramolecular Hydrogels |
| title_sort | preparation and biomedical applications of cucurbit n uril based supramolecular hydrogels |
| topic | cucurbit[n]urils supramolecular hydrogels biomedical host–guest interactions |
| url | https://www.mdpi.com/1420-3049/28/8/3566 |
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