Mycobacterium tuberculosis and myeloid-derived suppressor cells: Insights into caveolin rich lipid rafts
Mycobacterium tuberculosis (M.tb) is likely the most successful human pathogen, capable of evading protective host immune responses and driving metabolic changes to support its own survival and growth. Ineffective innate and adaptive immune responses inhibit effective clearance of the bacteria from...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-03-01
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| Series: | EBioMedicine |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396420300451 |
| _version_ | 1818962092494946304 |
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| author | Leigh A. Kotzé Carly Young Vinzeigh N. Leukes Vini John Zhuo Fang Gerhard Walzl Manfred B. Lutz Nelita du Plessis |
| author_facet | Leigh A. Kotzé Carly Young Vinzeigh N. Leukes Vini John Zhuo Fang Gerhard Walzl Manfred B. Lutz Nelita du Plessis |
| author_sort | Leigh A. Kotzé |
| collection | DOAJ |
| description | Mycobacterium tuberculosis (M.tb) is likely the most successful human pathogen, capable of evading protective host immune responses and driving metabolic changes to support its own survival and growth. Ineffective innate and adaptive immune responses inhibit effective clearance of the bacteria from the human host, resulting in the progression to active TB disease. Many regulatory mechanisms exist to prevent immunopathology, however, chronic infections result in the overproduction of regulatory myeloid cells, like myeloid-derived suppressor cells (MDSC), which actively suppress protective host T lymphocyte responses among other immunosuppressive mechanisms. The mechanisms of M.tb internalization by MDSC and the involvement of host-derived lipid acquisition, have not been fully elucidated. Targeted research aimed at investigating MDSC impact on phagocytic control of M.tb, would be advantageous to our collective anti-TB arsenal. In this review we propose a mechanism by which M.tb may be internalized by MDSC and survive via the manipulation of host-derived lipid sources. Keywords: Lipid metabolism, Caveolin, Mycobacterium tuberculosis, Myeloid-derived suppressor cells, Internalization |
| first_indexed | 2024-12-20T12:23:50Z |
| format | Article |
| id | doaj.art-1a0e3d9e8311438990e96e6f9a8af54f |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-12-20T12:23:50Z |
| publishDate | 2020-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-1a0e3d9e8311438990e96e6f9a8af54f2022-12-21T19:40:55ZengElsevierEBioMedicine2352-39642020-03-0153Mycobacterium tuberculosis and myeloid-derived suppressor cells: Insights into caveolin rich lipid raftsLeigh A. Kotzé0Carly Young1Vinzeigh N. Leukes2Vini John3Zhuo Fang4Gerhard Walzl5Manfred B. Lutz6Nelita du Plessis7DST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medical and Health Sciences, Stellenbosch University, Cape Town, South AfricaDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medical and Health Sciences, Stellenbosch University, Cape Town, South AfricaDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medical and Health Sciences, Stellenbosch University, Cape Town, South AfricaInstitute for Virology and Immunobiology, University of Würzburg, Würzburg, GermanyDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medical and Health Sciences, Stellenbosch University, Cape Town, South AfricaDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medical and Health Sciences, Stellenbosch University, Cape Town, South AfricaInstitute for Virology and Immunobiology, University of Würzburg, Würzburg, GermanyDST-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medical and Health Sciences, Stellenbosch University, Cape Town, South Africa; Corresponding author.Mycobacterium tuberculosis (M.tb) is likely the most successful human pathogen, capable of evading protective host immune responses and driving metabolic changes to support its own survival and growth. Ineffective innate and adaptive immune responses inhibit effective clearance of the bacteria from the human host, resulting in the progression to active TB disease. Many regulatory mechanisms exist to prevent immunopathology, however, chronic infections result in the overproduction of regulatory myeloid cells, like myeloid-derived suppressor cells (MDSC), which actively suppress protective host T lymphocyte responses among other immunosuppressive mechanisms. The mechanisms of M.tb internalization by MDSC and the involvement of host-derived lipid acquisition, have not been fully elucidated. Targeted research aimed at investigating MDSC impact on phagocytic control of M.tb, would be advantageous to our collective anti-TB arsenal. In this review we propose a mechanism by which M.tb may be internalized by MDSC and survive via the manipulation of host-derived lipid sources. Keywords: Lipid metabolism, Caveolin, Mycobacterium tuberculosis, Myeloid-derived suppressor cells, Internalizationhttp://www.sciencedirect.com/science/article/pii/S2352396420300451 |
| spellingShingle | Leigh A. Kotzé Carly Young Vinzeigh N. Leukes Vini John Zhuo Fang Gerhard Walzl Manfred B. Lutz Nelita du Plessis Mycobacterium tuberculosis and myeloid-derived suppressor cells: Insights into caveolin rich lipid rafts EBioMedicine |
| title | Mycobacterium tuberculosis and myeloid-derived suppressor cells: Insights into caveolin rich lipid rafts |
| title_full | Mycobacterium tuberculosis and myeloid-derived suppressor cells: Insights into caveolin rich lipid rafts |
| title_fullStr | Mycobacterium tuberculosis and myeloid-derived suppressor cells: Insights into caveolin rich lipid rafts |
| title_full_unstemmed | Mycobacterium tuberculosis and myeloid-derived suppressor cells: Insights into caveolin rich lipid rafts |
| title_short | Mycobacterium tuberculosis and myeloid-derived suppressor cells: Insights into caveolin rich lipid rafts |
| title_sort | mycobacterium tuberculosis and myeloid derived suppressor cells insights into caveolin rich lipid rafts |
| url | http://www.sciencedirect.com/science/article/pii/S2352396420300451 |
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