Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy
Stroke can cause death and disability, resulting in a huge burden on society. Parkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by motor dysfunction. Osteoarthritis (OA) is a progressive degenerative joint disease characterized by cartilage destruction and osteophyte for...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-03-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/0963689717723636 |
| _version_ | 1818392231138033664 |
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| author | Yu-Hsun Chang Kung-Chi Wu Horng-Jyh Harn Shinn-Zong Lin Dah-Ching Ding |
| author_facet | Yu-Hsun Chang Kung-Chi Wu Horng-Jyh Harn Shinn-Zong Lin Dah-Ching Ding |
| author_sort | Yu-Hsun Chang |
| collection | DOAJ |
| description | Stroke can cause death and disability, resulting in a huge burden on society. Parkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by motor dysfunction. Osteoarthritis (OA) is a progressive degenerative joint disease characterized by cartilage destruction and osteophyte formation in the joints. Stem cell therapy may provide a biological treatment alternative to traditional pharmacological therapy. Mesenchymal stem cells (MSCs) are preferred because of their differentiation ability and possible derivation from many adult tissues. In addition, the paracrine effects of MSCs play crucial anti-inflammatory and immunosuppressive roles in immune cells. Extracellular vesicles (EVs) are vital mediators of cell-to-cell communication. Exosomes contain various molecules such as microRNA (miRNA), which mediates biological functions through gene regulation. Therefore, exosomes carrying miRNA or other molecules can enhance the therapeutic effects of MSC transplantation. MSC-derived exosomes have been investigated in various animal models representing stroke, PD, and OA. Exosomes are a subtype of EVs. This review article focuses on the mechanism and therapeutic potential of MSC-derived exosomes in stroke, PD, and OA in basic and clinical aspects. |
| first_indexed | 2024-12-14T05:26:07Z |
| format | Article |
| id | doaj.art-1a0f7ec0b86f4d89867fe23fb8fa9c44 |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-14T05:26:07Z |
| publishDate | 2018-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-1a0f7ec0b86f4d89867fe23fb8fa9c442022-12-21T23:15:31ZengSAGE PublishingCell Transplantation0963-68971555-38922018-03-012710.1177/0963689717723636Exosomes and Stem Cells in Degenerative Disease Diagnosis and TherapyYu-Hsun Chang0Kung-Chi Wu1Horng-Jyh Harn2Shinn-Zong Lin3Dah-Ching Ding4 Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan Department of Orthopedics, Buddhist Tzu Chi General Hospital, Hualien, Taiwan Department of Pathology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan Department of Neurosurgery, Buddhist Tzu Chi General Hospital, Hualien, Taiwan Department of Obstetrics and Gynecology, Buddhist Tzu Chi General Hospital, Hualien, TaiwanStroke can cause death and disability, resulting in a huge burden on society. Parkinson’s disease (PD) is a chronic neurodegenerative disorder characterized by motor dysfunction. Osteoarthritis (OA) is a progressive degenerative joint disease characterized by cartilage destruction and osteophyte formation in the joints. Stem cell therapy may provide a biological treatment alternative to traditional pharmacological therapy. Mesenchymal stem cells (MSCs) are preferred because of their differentiation ability and possible derivation from many adult tissues. In addition, the paracrine effects of MSCs play crucial anti-inflammatory and immunosuppressive roles in immune cells. Extracellular vesicles (EVs) are vital mediators of cell-to-cell communication. Exosomes contain various molecules such as microRNA (miRNA), which mediates biological functions through gene regulation. Therefore, exosomes carrying miRNA or other molecules can enhance the therapeutic effects of MSC transplantation. MSC-derived exosomes have been investigated in various animal models representing stroke, PD, and OA. Exosomes are a subtype of EVs. This review article focuses on the mechanism and therapeutic potential of MSC-derived exosomes in stroke, PD, and OA in basic and clinical aspects.https://doi.org/10.1177/0963689717723636 |
| spellingShingle | Yu-Hsun Chang Kung-Chi Wu Horng-Jyh Harn Shinn-Zong Lin Dah-Ching Ding Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy Cell Transplantation |
| title | Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy |
| title_full | Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy |
| title_fullStr | Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy |
| title_full_unstemmed | Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy |
| title_short | Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy |
| title_sort | exosomes and stem cells in degenerative disease diagnosis and therapy |
| url | https://doi.org/10.1177/0963689717723636 |
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