One mutation away, the potential zoonotic threat – NeoCoV, planetary health impacts and the call for sustainability
A recent study entitled “Close relatives of MERS-CoV in bats use ACE2 as their functional receptors” posted on the bioRxiv preprint server has identified two close relatives of the Middle East Respiratory Syndrome coronavirus (MERS-CoV) in South African bats – NeoCoV and PDF-2180-CoV which can effi...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-03-01
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| Series: | Journal of Public Health Research |
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| Online Access: | https://www.jphres.org/index.php/jphres/article/view/2941 |
| _version_ | 1797967351851778048 |
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| author | Hana Chen Wei Jun Roy Rillera Marzo Tang Hooi Chia Saeid Mezail Mawazi Mohammad Yasir Essar |
| author_facet | Hana Chen Wei Jun Roy Rillera Marzo Tang Hooi Chia Saeid Mezail Mawazi Mohammad Yasir Essar |
| author_sort | Hana Chen Wei Jun |
| collection | DOAJ |
| description |
A recent study entitled “Close relatives of MERS-CoV in bats use ACE2 as their functional receptors” posted on the bioRxiv preprint server has identified two close relatives of the Middle East Respiratory Syndrome coronavirus (MERS-CoV) in South African bats – NeoCoV and PDF-2180-CoV which can efficiently use Angiotensin-converting enzyme 2 (ACE2) in bats but less so in humans. However, researchers suggested that NeoCoV could be infectious to humans via one key mutation – T510F mutation on the receptor-binding motif. As suggested that the origin of MERSCoV might be a result of intra-spike recombination between a NeoCoV-like virus and a DPP4-using virus, the nonhuman infectious NeoCoV firstly identified in 2011 is seen as a time boom,1 and this alarms the zoonotic potential of possible “MERS-CoV-2” using ACE2 in the future. As coronavirus outbreak is part of human causes of global change,2 recommendations are no longer limited to be preventive, but instead, sustainability should be planned to safeguard planetary health.
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| first_indexed | 2024-04-11T02:28:48Z |
| format | Article |
| id | doaj.art-1a120330dcf7419ba93d91d02d9769d3 |
| institution | Directory Open Access Journal |
| issn | 2279-9028 2279-9036 |
| language | English |
| last_indexed | 2024-04-11T02:28:48Z |
| publishDate | 2022-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Public Health Research |
| spelling | doaj.art-1a120330dcf7419ba93d91d02d9769d32023-01-02T21:45:53ZengSAGE PublishingJournal of Public Health Research2279-90282279-90362022-03-0110s210.4081/jphr.2021.2941One mutation away, the potential zoonotic threat – NeoCoV, planetary health impacts and the call for sustainabilityHana Chen Wei Jun0Roy Rillera Marzo1Tang Hooi Chia2Saeid Mezail Mawazi3Mohammad Yasir Essar4International Medical School, Management & Science University, SelangorInternational Medical School, Management & Science University, SelangorInternational Medical School, Management & Science University, SelangorSchool of Pharmacy, Management & Science University, SelangorKabul University of Medical Sciences, Kabul A recent study entitled “Close relatives of MERS-CoV in bats use ACE2 as their functional receptors” posted on the bioRxiv preprint server has identified two close relatives of the Middle East Respiratory Syndrome coronavirus (MERS-CoV) in South African bats – NeoCoV and PDF-2180-CoV which can efficiently use Angiotensin-converting enzyme 2 (ACE2) in bats but less so in humans. However, researchers suggested that NeoCoV could be infectious to humans via one key mutation – T510F mutation on the receptor-binding motif. As suggested that the origin of MERSCoV might be a result of intra-spike recombination between a NeoCoV-like virus and a DPP4-using virus, the nonhuman infectious NeoCoV firstly identified in 2011 is seen as a time boom,1 and this alarms the zoonotic potential of possible “MERS-CoV-2” using ACE2 in the future. As coronavirus outbreak is part of human causes of global change,2 recommendations are no longer limited to be preventive, but instead, sustainability should be planned to safeguard planetary health. https://www.jphres.org/index.php/jphres/article/view/2941NeoCovMERS-CoVcoronaviruszoonosisplanetary healthsustainability |
| spellingShingle | Hana Chen Wei Jun Roy Rillera Marzo Tang Hooi Chia Saeid Mezail Mawazi Mohammad Yasir Essar One mutation away, the potential zoonotic threat – NeoCoV, planetary health impacts and the call for sustainability Journal of Public Health Research NeoCov MERS-CoV coronavirus zoonosis planetary health sustainability |
| title | One mutation away, the potential zoonotic threat – NeoCoV, planetary health impacts and the call for sustainability |
| title_full | One mutation away, the potential zoonotic threat – NeoCoV, planetary health impacts and the call for sustainability |
| title_fullStr | One mutation away, the potential zoonotic threat – NeoCoV, planetary health impacts and the call for sustainability |
| title_full_unstemmed | One mutation away, the potential zoonotic threat – NeoCoV, planetary health impacts and the call for sustainability |
| title_short | One mutation away, the potential zoonotic threat – NeoCoV, planetary health impacts and the call for sustainability |
| title_sort | one mutation away the potential zoonotic threat neocov planetary health impacts and the call for sustainability |
| topic | NeoCov MERS-CoV coronavirus zoonosis planetary health sustainability |
| url | https://www.jphres.org/index.php/jphres/article/view/2941 |
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