Characterisation of the antifungal effects of a plant-based compound, CIN-102, on the main septal filamentous fungi involved in human pathology
ABSTRACT: Objectives: Today, the increase of invasive fungal infections and the emergence of resistant strains are observed in medical practice. New antifungals are expected, and the plant world offers a panel of potentially active molecules. CIN-102 is a mixture of seven different compounds of pla...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | Journal of Global Antimicrobial Resistance |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213716521000837 |
| _version_ | 1830308286097784832 |
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| author | Maurine D'Agostino Nicolas Tesse Rose Anne Lavergne Patrice Le Pape Jean Philippe Bouchara Jean Pol Frippiat Marie Machouart Anne Debourgogne |
| author_facet | Maurine D'Agostino Nicolas Tesse Rose Anne Lavergne Patrice Le Pape Jean Philippe Bouchara Jean Pol Frippiat Marie Machouart Anne Debourgogne |
| author_sort | Maurine D'Agostino |
| collection | DOAJ |
| description | ABSTRACT: Objectives: Today, the increase of invasive fungal infections and the emergence of resistant strains are observed in medical practice. New antifungals are expected, and the plant world offers a panel of potentially active molecules. CIN-102 is a mixture of seven different compounds of plant origin developed from the formulation of cinnamon essential oil. Methods: The in vitro activity of CIN-102 was characterised against Aspergillus spp., Fusarium spp. and Scedosporium spp. by studying the minimum inhibitory concentration (MIC), inoculum effect, germination inhibition, fungal growth, post-antifungal effect (PAFE) and synergy. Results: MICs determined for the three genera followed a unimodal distribution and their mean values ranged from 62–250 μg/mL. CIN-102 demonstrated an inoculum effect similar to voriconazole and amphotericin B, 100% inhibition of spore germination and a PAFE. Conclusion: CIN-102 has significant activity against filamentous fungi involved in human pathologies and should be further explored as a potential new treatment. Other studies regarding its mechanisms of action as well as animal investigations are awaited. |
| first_indexed | 2024-12-19T10:46:40Z |
| format | Article |
| id | doaj.art-1a125ca2a0d647afae648c4d4890f8e0 |
| institution | Directory Open Access Journal |
| issn | 2213-7165 |
| language | English |
| last_indexed | 2024-12-19T10:46:40Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Global Antimicrobial Resistance |
| spelling | doaj.art-1a125ca2a0d647afae648c4d4890f8e02022-12-21T20:25:13ZengElsevierJournal of Global Antimicrobial Resistance2213-71652021-06-0125171180Characterisation of the antifungal effects of a plant-based compound, CIN-102, on the main septal filamentous fungi involved in human pathologyMaurine D'Agostino0Nicolas Tesse1Rose Anne Lavergne2Patrice Le Pape3Jean Philippe Bouchara4Jean Pol Frippiat5Marie Machouart6Anne Debourgogne7Université de Lorraine, SIMPA, F-54000 Nancy, France; Corresponding author. (M. D'Agostino). Mailing address: Avenue de la Forêt de Haye, 54100 Vandoeuvre-lès-Nancy, France. Tel.: +33 3 72 74 63 13.Société Septeos, 12 avenue de la grande armée, 75017 Paris, FranceLaboratoire de Parasitologie-Mycologie, Institut de Biologie, CHU de Nantes, France, and Département de Parasitologie et Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155-IICiMed, Faculté de Pharmacie, Nantes, FranceLaboratoire de Parasitologie-Mycologie, Institut de Biologie, CHU de Nantes, France, and Département de Parasitologie et Mycologie Médicale, Université de Nantes, Nantes Atlantique Universités, EA1155-IICiMed, Faculté de Pharmacie, Nantes, FranceHost–Pathogen Interaction Study Group (GEIHP, EA 3142), SFR ICAT 4208, Univ. Angers, Univ. Brest, Angers University Hospital, Angers, FranceUniversité de Lorraine, SIMPA, F-54000 Nancy, FranceUniversité de Lorraine, SIMPA, F-54000 Nancy, France; Université de Lorraine, CHRU-Nancy, Laboratoire de Microbiologie, F-54000 Nancy, FranceUniversité de Lorraine, SIMPA, F-54000 Nancy, France; Université de Lorraine, CHRU-Nancy, Laboratoire de Microbiologie, F-54000 Nancy, FranceABSTRACT: Objectives: Today, the increase of invasive fungal infections and the emergence of resistant strains are observed in medical practice. New antifungals are expected, and the plant world offers a panel of potentially active molecules. CIN-102 is a mixture of seven different compounds of plant origin developed from the formulation of cinnamon essential oil. Methods: The in vitro activity of CIN-102 was characterised against Aspergillus spp., Fusarium spp. and Scedosporium spp. by studying the minimum inhibitory concentration (MIC), inoculum effect, germination inhibition, fungal growth, post-antifungal effect (PAFE) and synergy. Results: MICs determined for the three genera followed a unimodal distribution and their mean values ranged from 62–250 μg/mL. CIN-102 demonstrated an inoculum effect similar to voriconazole and amphotericin B, 100% inhibition of spore germination and a PAFE. Conclusion: CIN-102 has significant activity against filamentous fungi involved in human pathologies and should be further explored as a potential new treatment. Other studies regarding its mechanisms of action as well as animal investigations are awaited.http://www.sciencedirect.com/science/article/pii/S2213716521000837AntifungalFungiFusariumAspergillusScedosporium |
| spellingShingle | Maurine D'Agostino Nicolas Tesse Rose Anne Lavergne Patrice Le Pape Jean Philippe Bouchara Jean Pol Frippiat Marie Machouart Anne Debourgogne Characterisation of the antifungal effects of a plant-based compound, CIN-102, on the main septal filamentous fungi involved in human pathology Journal of Global Antimicrobial Resistance Antifungal Fungi Fusarium Aspergillus Scedosporium |
| title | Characterisation of the antifungal effects of a plant-based compound, CIN-102, on the main septal filamentous fungi involved in human pathology |
| title_full | Characterisation of the antifungal effects of a plant-based compound, CIN-102, on the main septal filamentous fungi involved in human pathology |
| title_fullStr | Characterisation of the antifungal effects of a plant-based compound, CIN-102, on the main septal filamentous fungi involved in human pathology |
| title_full_unstemmed | Characterisation of the antifungal effects of a plant-based compound, CIN-102, on the main septal filamentous fungi involved in human pathology |
| title_short | Characterisation of the antifungal effects of a plant-based compound, CIN-102, on the main septal filamentous fungi involved in human pathology |
| title_sort | characterisation of the antifungal effects of a plant based compound cin 102 on the main septal filamentous fungi involved in human pathology |
| topic | Antifungal Fungi Fusarium Aspergillus Scedosporium |
| url | http://www.sciencedirect.com/science/article/pii/S2213716521000837 |
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