Diagnostic value of urine cyclic RNA-0071196 for bladder urothelial carcinoma
Abstract Objective To investigate the diagnostic value of urine cyclic RNA-0071196 (circRNA-0071196) in the patients with bladder urothelial carcinoma (BUC). Method The expression of circRNA-0071196 was detected in the urine samples using qRT-PCR from 40 BUC patients and 30 non-UBC patients at our d...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | BMC Urology |
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| Online Access: | https://doi.org/10.1186/s12894-024-01466-z |
| _version_ | 1797199105989017600 |
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| author | Yang Yang Jun Li Weixiang Yao Ge Zou Xuying Ye Qishan Mo |
| author_facet | Yang Yang Jun Li Weixiang Yao Ge Zou Xuying Ye Qishan Mo |
| author_sort | Yang Yang |
| collection | DOAJ |
| description | Abstract Objective To investigate the diagnostic value of urine cyclic RNA-0071196 (circRNA-0071196) in the patients with bladder urothelial carcinoma (BUC). Method The expression of circRNA-0071196 was detected in the urine samples using qRT-PCR from 40 BUC patients and 30 non-UBC patients at our department from December 2018 to September 2021. The expression difference of circRNA-0071196 was compared between the two groups, and the relationship between the expression of circRNA-0071196 in the urine of UBC patients and the clinical pathological characteristics was analyzed. Results (1) The expression of circRNA-0071196 in the urine of BUC group was significantly higher than that in the non-BUC group (P < 0.05). (2) The expression of circRNA-0071196 in the urine of BUC group was not related to age, sex, or lymph node metastasis (P > 0.05). (3) The expression of circRNA-0071196 in the urine of BUC group was related to tumor T stage, tumor grade and muscle invasion. (4) The urine circRNA-0071196 expression effectively distinguished BUC patients from non-BUC patients. Conclusion The elevated expression of urine circRNA-0071196 in BUC patients indicates that circRNA-0071196 has promising potential as a non-invasive urinary biomarker for detecting BUC. |
| first_indexed | 2024-04-24T07:10:28Z |
| format | Article |
| id | doaj.art-1a133314faf34439be30af3de5aeebc4 |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-04-24T07:10:28Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-1a133314faf34439be30af3de5aeebc42024-04-21T11:31:30ZengBMCBMC Urology1471-24902024-04-012411610.1186/s12894-024-01466-zDiagnostic value of urine cyclic RNA-0071196 for bladder urothelial carcinomaYang Yang0Jun Li1Weixiang Yao2Ge Zou3Xuying Ye4Qishan Mo5Department of Urology, Panyu District Central HospitalDepartment of Urology, Panyu District Central HospitalDepartment of Urology, Panyu District Central HospitalDepartment of Urology, Panyu District Central HospitalDepartment of Urology, Panyu District Central HospitalDepartment of Urology, Panyu District Central HospitalAbstract Objective To investigate the diagnostic value of urine cyclic RNA-0071196 (circRNA-0071196) in the patients with bladder urothelial carcinoma (BUC). Method The expression of circRNA-0071196 was detected in the urine samples using qRT-PCR from 40 BUC patients and 30 non-UBC patients at our department from December 2018 to September 2021. The expression difference of circRNA-0071196 was compared between the two groups, and the relationship between the expression of circRNA-0071196 in the urine of UBC patients and the clinical pathological characteristics was analyzed. Results (1) The expression of circRNA-0071196 in the urine of BUC group was significantly higher than that in the non-BUC group (P < 0.05). (2) The expression of circRNA-0071196 in the urine of BUC group was not related to age, sex, or lymph node metastasis (P > 0.05). (3) The expression of circRNA-0071196 in the urine of BUC group was related to tumor T stage, tumor grade and muscle invasion. (4) The urine circRNA-0071196 expression effectively distinguished BUC patients from non-BUC patients. Conclusion The elevated expression of urine circRNA-0071196 in BUC patients indicates that circRNA-0071196 has promising potential as a non-invasive urinary biomarker for detecting BUC.https://doi.org/10.1186/s12894-024-01466-zBladder urothelial carcinomaCircular RNA-0071196Analysis of clinical case characteristics |
| spellingShingle | Yang Yang Jun Li Weixiang Yao Ge Zou Xuying Ye Qishan Mo Diagnostic value of urine cyclic RNA-0071196 for bladder urothelial carcinoma BMC Urology Bladder urothelial carcinoma Circular RNA-0071196 Analysis of clinical case characteristics |
| title | Diagnostic value of urine cyclic RNA-0071196 for bladder urothelial carcinoma |
| title_full | Diagnostic value of urine cyclic RNA-0071196 for bladder urothelial carcinoma |
| title_fullStr | Diagnostic value of urine cyclic RNA-0071196 for bladder urothelial carcinoma |
| title_full_unstemmed | Diagnostic value of urine cyclic RNA-0071196 for bladder urothelial carcinoma |
| title_short | Diagnostic value of urine cyclic RNA-0071196 for bladder urothelial carcinoma |
| title_sort | diagnostic value of urine cyclic rna 0071196 for bladder urothelial carcinoma |
| topic | Bladder urothelial carcinoma Circular RNA-0071196 Analysis of clinical case characteristics |
| url | https://doi.org/10.1186/s12894-024-01466-z |
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