Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies
The physiological roles of proteolysis are not limited to degrading unnecessary proteins. Proteolysis plays pivotal roles in various biological processes through cleaving peptide bonds to activate and inactivate proteins including enzymes, transcription factors, and receptors. As a wide range of cel...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.876370/full |
| _version_ | 1818193645580320768 |
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| author | Daiji Kiyozumi Daiji Kiyozumi Masahito Ikawa Masahito Ikawa Masahito Ikawa |
| author_facet | Daiji Kiyozumi Daiji Kiyozumi Masahito Ikawa Masahito Ikawa Masahito Ikawa |
| author_sort | Daiji Kiyozumi |
| collection | DOAJ |
| description | The physiological roles of proteolysis are not limited to degrading unnecessary proteins. Proteolysis plays pivotal roles in various biological processes through cleaving peptide bonds to activate and inactivate proteins including enzymes, transcription factors, and receptors. As a wide range of cellular processes is regulated by proteolysis, abnormalities or dysregulation of such proteolytic processes therefore often cause diseases. Recent genetic studies have clarified the inclusion of proteases and protease inhibitors in various reproductive processes such as development of gonads, generation and activation of gametes, and physical interaction between gametes in various species including yeast, animals, and plants. Such studies not only clarify proteolysis-related factors but the biological processes regulated by proteolysis for successful reproduction. Here the physiological roles of proteases and proteolysis in reproduction will be reviewed based on findings using gene-modified organisms. |
| first_indexed | 2024-12-12T00:49:42Z |
| format | Article |
| id | doaj.art-1a1355b5869841ffb28235bda34a4085 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-12T00:49:42Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-1a1355b5869841ffb28235bda34a40852022-12-22T00:44:02ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-05-011310.3389/fendo.2022.876370876370Proteolysis in Reproduction: Lessons From Gene-Modified Organism StudiesDaiji Kiyozumi0Daiji Kiyozumi1Masahito Ikawa2Masahito Ikawa3Masahito Ikawa4Research Institute for Microbial Diseases, Osaka University, Suita, JapanPRESTO, Japan Science and Technology Agency, Kawaguchi, JapanResearch Institute for Microbial Diseases, Osaka University, Suita, JapanThe Institute of Medical Science, The University of Tokyo, Tokyo, JapanCREST, Japan Science and Technology Agency, Kawaguchi, JapanThe physiological roles of proteolysis are not limited to degrading unnecessary proteins. Proteolysis plays pivotal roles in various biological processes through cleaving peptide bonds to activate and inactivate proteins including enzymes, transcription factors, and receptors. As a wide range of cellular processes is regulated by proteolysis, abnormalities or dysregulation of such proteolytic processes therefore often cause diseases. Recent genetic studies have clarified the inclusion of proteases and protease inhibitors in various reproductive processes such as development of gonads, generation and activation of gametes, and physical interaction between gametes in various species including yeast, animals, and plants. Such studies not only clarify proteolysis-related factors but the biological processes regulated by proteolysis for successful reproduction. Here the physiological roles of proteases and proteolysis in reproduction will be reviewed based on findings using gene-modified organisms.https://www.frontiersin.org/articles/10.3389/fendo.2022.876370/fullproteasefertilizationproteolysisprotease inhibitorpseudoproteasegene-modified animal models |
| spellingShingle | Daiji Kiyozumi Daiji Kiyozumi Masahito Ikawa Masahito Ikawa Masahito Ikawa Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies Frontiers in Endocrinology protease fertilization proteolysis protease inhibitor pseudoprotease gene-modified animal models |
| title | Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies |
| title_full | Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies |
| title_fullStr | Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies |
| title_full_unstemmed | Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies |
| title_short | Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies |
| title_sort | proteolysis in reproduction lessons from gene modified organism studies |
| topic | protease fertilization proteolysis protease inhibitor pseudoprotease gene-modified animal models |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.876370/full |
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