Post-treatment benign changes versus recurrence in non-lymphoid head and neck malignancies: can diffusion-weighted magnetic resonance imaging end up the diagnostic challenge?
Abstract Background The aim of this prospective cohort study is to substantiate the added value of diffusion-weighted magnetic resonance imaging (DW-MRI) over conventional MRI assessment in the differentiation between locoregional recurrence/residual tumour and post-treatment benign changes in patie...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-04-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
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| Online Access: | http://link.springer.com/article/10.1186/s43055-020-00177-3 |
| _version_ | 1828453512376221696 |
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| author | Dalia K. Serour Khaled M. Adel Ayman M. A. Osman |
| author_facet | Dalia K. Serour Khaled M. Adel Ayman M. A. Osman |
| author_sort | Dalia K. Serour |
| collection | DOAJ |
| description | Abstract Background The aim of this prospective cohort study is to substantiate the added value of diffusion-weighted magnetic resonance imaging (DW-MRI) over conventional MRI assessment in the differentiation between locoregional recurrence/residual tumour and post-treatment benign changes in patients with non-lymphoid head and neck malignancies. Thirty adult patients, each with a suspicious lesion on post-treatment imaging scans at the primary site of a previously treated non-lymphoid head and neck malignancy, were evaluated by MRI and diffusion-weighted imaging (DWI). The apparent diffusion coefficient (ADC) values of the lesions were calculated. Results Diffusion-weighted MRI yielded an accuracy of 90%, a sensitivity of 88.9%, a specificity of 91.7%, a positive predictive value of 94.1% and a negative predictive value of 84.6%. The mean ADC value of the lesions was lower in the “locoregional recurrence/residual tumour” group (1.08 × 10−3 mm2/s) compared to the “post-treatment benign changes” group (1.95 × 10−3 mm2/s); P < 0.001. An ADC cutoff value of 1.43 × 10−3 mm2/s achieved the same accuracy as the visual assessment by DW-MRI. Conclusion Incorporating the DWI sequence into the post-treatment imaging assessment protocol brings a substantial added value to conventional MRI assessment in patients with non-lymphoid head and neck malignancies. This valuable merit of DW-MRI can help avoid or, at least, largely minimize unnecessary or unfeasible tissue sampling. An ADC cutoff value of 1.43 × 10−3 mm2/s can also be utilized to aid in the assessment process. |
| first_indexed | 2024-12-11T00:07:28Z |
| format | Article |
| id | doaj.art-1a147d620f0e4e25b90463f8657bd852 |
| institution | Directory Open Access Journal |
| issn | 2090-4762 |
| language | English |
| last_indexed | 2024-12-11T00:07:28Z |
| publishDate | 2020-04-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-1a147d620f0e4e25b90463f8657bd8522022-12-22T01:28:16ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622020-04-0151111010.1186/s43055-020-00177-3Post-treatment benign changes versus recurrence in non-lymphoid head and neck malignancies: can diffusion-weighted magnetic resonance imaging end up the diagnostic challenge?Dalia K. Serour0Khaled M. Adel1Ayman M. A. Osman2Department of Diagnostic and Interventional Radiology, Faculty of Medicine, Cairo UniversityDepartment of Diagnostic and Interventional Radiology, Faculty of Medicine, Cairo UniversityDepartment of General Surgery, Faculty of Medicine, Cairo UniversityAbstract Background The aim of this prospective cohort study is to substantiate the added value of diffusion-weighted magnetic resonance imaging (DW-MRI) over conventional MRI assessment in the differentiation between locoregional recurrence/residual tumour and post-treatment benign changes in patients with non-lymphoid head and neck malignancies. Thirty adult patients, each with a suspicious lesion on post-treatment imaging scans at the primary site of a previously treated non-lymphoid head and neck malignancy, were evaluated by MRI and diffusion-weighted imaging (DWI). The apparent diffusion coefficient (ADC) values of the lesions were calculated. Results Diffusion-weighted MRI yielded an accuracy of 90%, a sensitivity of 88.9%, a specificity of 91.7%, a positive predictive value of 94.1% and a negative predictive value of 84.6%. The mean ADC value of the lesions was lower in the “locoregional recurrence/residual tumour” group (1.08 × 10−3 mm2/s) compared to the “post-treatment benign changes” group (1.95 × 10−3 mm2/s); P < 0.001. An ADC cutoff value of 1.43 × 10−3 mm2/s achieved the same accuracy as the visual assessment by DW-MRI. Conclusion Incorporating the DWI sequence into the post-treatment imaging assessment protocol brings a substantial added value to conventional MRI assessment in patients with non-lymphoid head and neck malignancies. This valuable merit of DW-MRI can help avoid or, at least, largely minimize unnecessary or unfeasible tissue sampling. An ADC cutoff value of 1.43 × 10−3 mm2/s can also be utilized to aid in the assessment process.http://link.springer.com/article/10.1186/s43055-020-00177-3Diffusion-weighted magnetic resonance imagingHead and neckNon-lymphoid malignanciesRecurrencePost-treatment benign changesApparent diffusion coefficient |
| spellingShingle | Dalia K. Serour Khaled M. Adel Ayman M. A. Osman Post-treatment benign changes versus recurrence in non-lymphoid head and neck malignancies: can diffusion-weighted magnetic resonance imaging end up the diagnostic challenge? The Egyptian Journal of Radiology and Nuclear Medicine Diffusion-weighted magnetic resonance imaging Head and neck Non-lymphoid malignancies Recurrence Post-treatment benign changes Apparent diffusion coefficient |
| title | Post-treatment benign changes versus recurrence in non-lymphoid head and neck malignancies: can diffusion-weighted magnetic resonance imaging end up the diagnostic challenge? |
| title_full | Post-treatment benign changes versus recurrence in non-lymphoid head and neck malignancies: can diffusion-weighted magnetic resonance imaging end up the diagnostic challenge? |
| title_fullStr | Post-treatment benign changes versus recurrence in non-lymphoid head and neck malignancies: can diffusion-weighted magnetic resonance imaging end up the diagnostic challenge? |
| title_full_unstemmed | Post-treatment benign changes versus recurrence in non-lymphoid head and neck malignancies: can diffusion-weighted magnetic resonance imaging end up the diagnostic challenge? |
| title_short | Post-treatment benign changes versus recurrence in non-lymphoid head and neck malignancies: can diffusion-weighted magnetic resonance imaging end up the diagnostic challenge? |
| title_sort | post treatment benign changes versus recurrence in non lymphoid head and neck malignancies can diffusion weighted magnetic resonance imaging end up the diagnostic challenge |
| topic | Diffusion-weighted magnetic resonance imaging Head and neck Non-lymphoid malignancies Recurrence Post-treatment benign changes Apparent diffusion coefficient |
| url | http://link.springer.com/article/10.1186/s43055-020-00177-3 |
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