Differences in Glycemic Abnormalities Between Primary Aldosteronism and Essential Hypertension: A Systematic Review and Meta-Analysis
BackgroundThe relationship of glycemic abnormalities between primary aldosteronism (PA) patients and essential hypertension (EH) patients is still debatable. This meta-analysis aimed to explore differences in the prevalence of glycemic abnormalities and levels of abnormal glucose metabolism in PA an...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-03-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.870047/full |
| _version_ | 1819157650108055552 |
|---|---|
| author | Worapaka Manosroi Pichitchai Atthakomol Pichitchai Atthakomol Pittaporn Wattanawitawas Supawan Buranapin |
| author_facet | Worapaka Manosroi Pichitchai Atthakomol Pichitchai Atthakomol Pittaporn Wattanawitawas Supawan Buranapin |
| author_sort | Worapaka Manosroi |
| collection | DOAJ |
| description | BackgroundThe relationship of glycemic abnormalities between primary aldosteronism (PA) patients and essential hypertension (EH) patients is still debatable. This meta-analysis aimed to explore differences in the prevalence of glycemic abnormalities and levels of abnormal glucose metabolism in PA and EH patients.MethodsA search was performed using PubMed, Scopus, Cochrane and Web of Science databases from their inception through January 2022. Inclusion criteria for this study were 1) observational studies which contained specific data of interest, 2) studies including data which compared adult PA and EH patients and 3) studies which used appropriate methods to diagnose PA. Risk ratio (RR) or standardized mean difference (SMD) with a 95% confidence interval (95% CI) was calculated.ResultsTwenty-six studies involving 53,186 patients were included in the meta-analysis. Patients with PA demonstrated significantly higher overall incidence of glycemic abnormalities than patients with EH [RR 1.54; 95% CI (1.20,1.98)]. Risk of diabetes mellitus (DM) and impaired glucose tolerance (IGT) in PA patients were higher than in EH patients [RR 1.27; 95%CI (1.08, 1.49) and RR 2.99; 95%CI (1.74, 5.16), respectively]. There was no statistically significant difference of risk between these groups for impaired fasting glucose (IFG) [RR 1.70; 95%CI (0.55, 5.26)]. Moderate heterogeneity was observed in overall glycemic abnormalities outcomes. A high level of heterogeneity was observed for IFG, while the level was low for DM and IGT.ConclusionsPA patients have a higher risk of glycemic abnormalities than in EH patients. Further study should be conducted to investigate underlying mechanisms of glycemic abnormalities in PA.Systematic Review Registrationwww.inplasy.com, INPLASY, identifier 202220004. |
| first_indexed | 2024-12-22T16:12:08Z |
| format | Article |
| id | doaj.art-1a158d1da5eb447bae153557dfa25b63 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-22T16:12:08Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-1a158d1da5eb447bae153557dfa25b632022-12-21T18:20:27ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-03-011310.3389/fendo.2022.870047870047Differences in Glycemic Abnormalities Between Primary Aldosteronism and Essential Hypertension: A Systematic Review and Meta-AnalysisWorapaka Manosroi0Pichitchai Atthakomol1Pichitchai Atthakomol2Pittaporn Wattanawitawas3Supawan Buranapin4Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandOrthopaedics Department, Faculty of Medicine, Chiang Mai University, Muang Chiang Mai, Chiang Mai, ThailandClinical Epidemiology and Clinical Statistic Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandDivision of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandDivision of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, ThailandBackgroundThe relationship of glycemic abnormalities between primary aldosteronism (PA) patients and essential hypertension (EH) patients is still debatable. This meta-analysis aimed to explore differences in the prevalence of glycemic abnormalities and levels of abnormal glucose metabolism in PA and EH patients.MethodsA search was performed using PubMed, Scopus, Cochrane and Web of Science databases from their inception through January 2022. Inclusion criteria for this study were 1) observational studies which contained specific data of interest, 2) studies including data which compared adult PA and EH patients and 3) studies which used appropriate methods to diagnose PA. Risk ratio (RR) or standardized mean difference (SMD) with a 95% confidence interval (95% CI) was calculated.ResultsTwenty-six studies involving 53,186 patients were included in the meta-analysis. Patients with PA demonstrated significantly higher overall incidence of glycemic abnormalities than patients with EH [RR 1.54; 95% CI (1.20,1.98)]. Risk of diabetes mellitus (DM) and impaired glucose tolerance (IGT) in PA patients were higher than in EH patients [RR 1.27; 95%CI (1.08, 1.49) and RR 2.99; 95%CI (1.74, 5.16), respectively]. There was no statistically significant difference of risk between these groups for impaired fasting glucose (IFG) [RR 1.70; 95%CI (0.55, 5.26)]. Moderate heterogeneity was observed in overall glycemic abnormalities outcomes. A high level of heterogeneity was observed for IFG, while the level was low for DM and IGT.ConclusionsPA patients have a higher risk of glycemic abnormalities than in EH patients. Further study should be conducted to investigate underlying mechanisms of glycemic abnormalities in PA.Systematic Review Registrationwww.inplasy.com, INPLASY, identifier 202220004.https://www.frontiersin.org/articles/10.3389/fendo.2022.870047/fullprimary aldosteronismessential hypertensiondiabetes mellitusimpaired fasting glucoseimpaired glucose toleranceinsulin resistance |
| spellingShingle | Worapaka Manosroi Pichitchai Atthakomol Pichitchai Atthakomol Pittaporn Wattanawitawas Supawan Buranapin Differences in Glycemic Abnormalities Between Primary Aldosteronism and Essential Hypertension: A Systematic Review and Meta-Analysis Frontiers in Endocrinology primary aldosteronism essential hypertension diabetes mellitus impaired fasting glucose impaired glucose tolerance insulin resistance |
| title | Differences in Glycemic Abnormalities Between Primary Aldosteronism and Essential Hypertension: A Systematic Review and Meta-Analysis |
| title_full | Differences in Glycemic Abnormalities Between Primary Aldosteronism and Essential Hypertension: A Systematic Review and Meta-Analysis |
| title_fullStr | Differences in Glycemic Abnormalities Between Primary Aldosteronism and Essential Hypertension: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Differences in Glycemic Abnormalities Between Primary Aldosteronism and Essential Hypertension: A Systematic Review and Meta-Analysis |
| title_short | Differences in Glycemic Abnormalities Between Primary Aldosteronism and Essential Hypertension: A Systematic Review and Meta-Analysis |
| title_sort | differences in glycemic abnormalities between primary aldosteronism and essential hypertension a systematic review and meta analysis |
| topic | primary aldosteronism essential hypertension diabetes mellitus impaired fasting glucose impaired glucose tolerance insulin resistance |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.870047/full |
| work_keys_str_mv | AT worapakamanosroi differencesinglycemicabnormalitiesbetweenprimaryaldosteronismandessentialhypertensionasystematicreviewandmetaanalysis AT pichitchaiatthakomol differencesinglycemicabnormalitiesbetweenprimaryaldosteronismandessentialhypertensionasystematicreviewandmetaanalysis AT pichitchaiatthakomol differencesinglycemicabnormalitiesbetweenprimaryaldosteronismandessentialhypertensionasystematicreviewandmetaanalysis AT pittapornwattanawitawas differencesinglycemicabnormalitiesbetweenprimaryaldosteronismandessentialhypertensionasystematicreviewandmetaanalysis AT supawanburanapin differencesinglycemicabnormalitiesbetweenprimaryaldosteronismandessentialhypertensionasystematicreviewandmetaanalysis |