Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin–Yang Collaboration
Cellular communication network factor (CCN) 2 and 3 are the members of the CCN family that conduct the harmonized development of a variety of tissues and organs under interaction with multiple biomolecules in the microenvironment. Despite their striking structural similarities, these two members sho...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-05-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/11/5887 |
| _version_ | 1797493281957871616 |
|---|---|
| author | Satoshi Kubota Kazumi Kawata Takako Hattori Takashi Nishida |
| author_facet | Satoshi Kubota Kazumi Kawata Takako Hattori Takashi Nishida |
| author_sort | Satoshi Kubota |
| collection | DOAJ |
| description | Cellular communication network factor (CCN) 2 and 3 are the members of the CCN family that conduct the harmonized development of a variety of tissues and organs under interaction with multiple biomolecules in the microenvironment. Despite their striking structural similarities, these two members show contrastive molecular functions as well as temporospatial emergence in living tissues. Typically, CCN2 promotes cell growth, whereas CCN3 restrains it. Where CCN2 is produced, CCN3 disappears. Nevertheless, these two proteins collaborate together to execute their mission in a yin–yang fashion. The apparent functional counteractions of CCN2 and CCN3 can be ascribed to their direct molecular interaction and interference over the cofactors that are shared by the two. Recent studies have revealed the mutual negative regulation systems between CCN2 and CCN3. Moreover, the simultaneous and bidirectional regulatory system of CCN2 and CCN3 is also being clarified. It is of particular note that these regulations were found to be closely associated with glycolysis, a fundamental procedure of energy metabolism. Here, the molecular interplay and metabolic gene regulation that enable the yin–yang collaboration of CCN2 and CCN3 typically found in cartilage development/regeneration and fibrosis are described. |
| first_indexed | 2024-03-10T01:17:46Z |
| format | Article |
| id | doaj.art-1a17b7e39cef4c6d8ce29b5ba4c964ef |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:17:46Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1a17b7e39cef4c6d8ce29b5ba4c964ef2023-11-23T14:05:51ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-012311588710.3390/ijms23115887Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin–Yang CollaborationSatoshi Kubota0Kazumi Kawata1Takako Hattori2Takashi Nishida3Department of Biochemistry and Molecular Dentistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, JapanDepartment of Biochemistry and Molecular Dentistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, JapanDepartment of Biochemistry and Molecular Dentistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, JapanDepartment of Biochemistry and Molecular Dentistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, JapanCellular communication network factor (CCN) 2 and 3 are the members of the CCN family that conduct the harmonized development of a variety of tissues and organs under interaction with multiple biomolecules in the microenvironment. Despite their striking structural similarities, these two members show contrastive molecular functions as well as temporospatial emergence in living tissues. Typically, CCN2 promotes cell growth, whereas CCN3 restrains it. Where CCN2 is produced, CCN3 disappears. Nevertheless, these two proteins collaborate together to execute their mission in a yin–yang fashion. The apparent functional counteractions of CCN2 and CCN3 can be ascribed to their direct molecular interaction and interference over the cofactors that are shared by the two. Recent studies have revealed the mutual negative regulation systems between CCN2 and CCN3. Moreover, the simultaneous and bidirectional regulatory system of CCN2 and CCN3 is also being clarified. It is of particular note that these regulations were found to be closely associated with glycolysis, a fundamental procedure of energy metabolism. Here, the molecular interplay and metabolic gene regulation that enable the yin–yang collaboration of CCN2 and CCN3 typically found in cartilage development/regeneration and fibrosis are described.https://www.mdpi.com/1422-0067/23/11/5887cellular communication network factorCCN2CCN3cartilagefibrosisglycolysis |
| spellingShingle | Satoshi Kubota Kazumi Kawata Takako Hattori Takashi Nishida Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin–Yang Collaboration International Journal of Molecular Sciences cellular communication network factor CCN2 CCN3 cartilage fibrosis glycolysis |
| title | Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin–Yang Collaboration |
| title_full | Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin–Yang Collaboration |
| title_fullStr | Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin–Yang Collaboration |
| title_full_unstemmed | Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin–Yang Collaboration |
| title_short | Molecular and Genetic Interactions between CCN2 and CCN3 behind Their Yin–Yang Collaboration |
| title_sort | molecular and genetic interactions between ccn2 and ccn3 behind their yin yang collaboration |
| topic | cellular communication network factor CCN2 CCN3 cartilage fibrosis glycolysis |
| url | https://www.mdpi.com/1422-0067/23/11/5887 |
| work_keys_str_mv | AT satoshikubota molecularandgeneticinteractionsbetweenccn2andccn3behindtheiryinyangcollaboration AT kazumikawata molecularandgeneticinteractionsbetweenccn2andccn3behindtheiryinyangcollaboration AT takakohattori molecularandgeneticinteractionsbetweenccn2andccn3behindtheiryinyangcollaboration AT takashinishida molecularandgeneticinteractionsbetweenccn2andccn3behindtheiryinyangcollaboration |