Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome
Objective: To investigated beneficial effect of Curcumin (a phenolic curcuminoid derivative from Curcuma longa) in Letrozole induced PCOS in female Wistar rats. Methods: Letrozole (1 mg/kg) was administered per orally (p.o) for a period of 21 days for the induction of PCOS, followed by dose of Curcu...
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Format: | Article |
Language: | English |
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Wolters Kluwer Medknow Publications
2016-04-01
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Series: | Asian Pacific Journal of Reproduction |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2305050016000154 |
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author | P. Sushma Reddy Nazia Begum Sumith Mutha Vasudha Bakshi |
author_facet | P. Sushma Reddy Nazia Begum Sumith Mutha Vasudha Bakshi |
author_sort | P. Sushma Reddy |
collection | DOAJ |
description | Objective: To investigated beneficial effect of Curcumin (a phenolic curcuminoid derivative from Curcuma longa) in Letrozole induced PCOS in female Wistar rats.
Methods: Letrozole (1 mg/kg) was administered per orally (p.o) for a period of 21 days for the induction of PCOS, followed by dose of Curcumin (100 mg/kg and 200 mg/kg, p.o) for 15 days using 0.5% w/v CMC as vehicle.
Results: The administration of Letrozole led to abnormalcy in serum sex steroid profile, lipid profile, glucose and glycosylated hemoglobin levels and depletion in antioxidant activity. Curcumin was able to successfully exert its protective effect by restoring all the parameters to normal and disappearance of cysts in ovaries.
Conclusion: Curcumin showed beneficial effects in Letrozole induced PCOS in female Wistar rats. Its effect was comparable to that of Clomiphene citrate, most widely used treatment for ovulation induction in PCOS condition. |
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format | Article |
id | doaj.art-1a17cc47e71a492fac264e916352c023 |
institution | Directory Open Access Journal |
issn | 2305-0500 |
language | English |
last_indexed | 2024-12-11T07:59:07Z |
publishDate | 2016-04-01 |
publisher | Wolters Kluwer Medknow Publications |
record_format | Article |
series | Asian Pacific Journal of Reproduction |
spelling | doaj.art-1a17cc47e71a492fac264e916352c0232022-12-22T01:15:09ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Reproduction2305-05002016-04-015211612210.1016/j.apjr.2016.01.006Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndromeP. Sushma Reddy0Nazia Begum1Sumith Mutha2Vasudha Bakshi3Department of Pharmacology, School of Pharmacy, Anurag Group of Institutions, 500088, Hyderabad, IndiaDepartment of Pharmacology, School of Pharmacy, Anurag Group of Institutions, 500088, Hyderabad, IndiaDepartment of Pharmacology, School of Pharmacy, Anurag Group of Institutions, 500088, Hyderabad, IndiaDepartment of Pharmacology, Lalitha College of Pharmacy, Anurag Group of Institutions, Ghatkesar, Ranga Reddy Dist, 500088, Hyderabad, Telangana, IndiaObjective: To investigated beneficial effect of Curcumin (a phenolic curcuminoid derivative from Curcuma longa) in Letrozole induced PCOS in female Wistar rats. Methods: Letrozole (1 mg/kg) was administered per orally (p.o) for a period of 21 days for the induction of PCOS, followed by dose of Curcumin (100 mg/kg and 200 mg/kg, p.o) for 15 days using 0.5% w/v CMC as vehicle. Results: The administration of Letrozole led to abnormalcy in serum sex steroid profile, lipid profile, glucose and glycosylated hemoglobin levels and depletion in antioxidant activity. Curcumin was able to successfully exert its protective effect by restoring all the parameters to normal and disappearance of cysts in ovaries. Conclusion: Curcumin showed beneficial effects in Letrozole induced PCOS in female Wistar rats. Its effect was comparable to that of Clomiphene citrate, most widely used treatment for ovulation induction in PCOS condition.http://www.sciencedirect.com/science/article/pii/S2305050016000154PCOSLetrozoleCurcuminCysts |
spellingShingle | P. Sushma Reddy Nazia Begum Sumith Mutha Vasudha Bakshi Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome Asian Pacific Journal of Reproduction PCOS Letrozole Curcumin Cysts |
title | Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome |
title_full | Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome |
title_fullStr | Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome |
title_full_unstemmed | Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome |
title_short | Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome |
title_sort | beneficial effect of curcumin in letrozole induced polycystic ovary syndrome |
topic | PCOS Letrozole Curcumin Cysts |
url | http://www.sciencedirect.com/science/article/pii/S2305050016000154 |
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