Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome

Objective: To investigated beneficial effect of Curcumin (a phenolic curcuminoid derivative from Curcuma longa) in Letrozole induced PCOS in female Wistar rats. Methods: Letrozole (1 mg/kg) was administered per orally (p.o) for a period of 21 days for the induction of PCOS, followed by dose of Curcu...

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Main Authors: P. Sushma Reddy, Nazia Begum, Sumith Mutha, Vasudha Bakshi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-04-01
Series:Asian Pacific Journal of Reproduction
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2305050016000154
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author P. Sushma Reddy
Nazia Begum
Sumith Mutha
Vasudha Bakshi
author_facet P. Sushma Reddy
Nazia Begum
Sumith Mutha
Vasudha Bakshi
author_sort P. Sushma Reddy
collection DOAJ
description Objective: To investigated beneficial effect of Curcumin (a phenolic curcuminoid derivative from Curcuma longa) in Letrozole induced PCOS in female Wistar rats. Methods: Letrozole (1 mg/kg) was administered per orally (p.o) for a period of 21 days for the induction of PCOS, followed by dose of Curcumin (100 mg/kg and 200 mg/kg, p.o) for 15 days using 0.5% w/v CMC as vehicle. Results: The administration of Letrozole led to abnormalcy in serum sex steroid profile, lipid profile, glucose and glycosylated hemoglobin levels and depletion in antioxidant activity. Curcumin was able to successfully exert its protective effect by restoring all the parameters to normal and disappearance of cysts in ovaries. Conclusion: Curcumin showed beneficial effects in Letrozole induced PCOS in female Wistar rats. Its effect was comparable to that of Clomiphene citrate, most widely used treatment for ovulation induction in PCOS condition.
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spelling doaj.art-1a17cc47e71a492fac264e916352c0232022-12-22T01:15:09ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Reproduction2305-05002016-04-015211612210.1016/j.apjr.2016.01.006Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndromeP. Sushma Reddy0Nazia Begum1Sumith Mutha2Vasudha Bakshi3Department of Pharmacology, School of Pharmacy, Anurag Group of Institutions, 500088, Hyderabad, IndiaDepartment of Pharmacology, School of Pharmacy, Anurag Group of Institutions, 500088, Hyderabad, IndiaDepartment of Pharmacology, School of Pharmacy, Anurag Group of Institutions, 500088, Hyderabad, IndiaDepartment of Pharmacology, Lalitha College of Pharmacy, Anurag Group of Institutions, Ghatkesar, Ranga Reddy Dist, 500088, Hyderabad, Telangana, IndiaObjective: To investigated beneficial effect of Curcumin (a phenolic curcuminoid derivative from Curcuma longa) in Letrozole induced PCOS in female Wistar rats. Methods: Letrozole (1 mg/kg) was administered per orally (p.o) for a period of 21 days for the induction of PCOS, followed by dose of Curcumin (100 mg/kg and 200 mg/kg, p.o) for 15 days using 0.5% w/v CMC as vehicle. Results: The administration of Letrozole led to abnormalcy in serum sex steroid profile, lipid profile, glucose and glycosylated hemoglobin levels and depletion in antioxidant activity. Curcumin was able to successfully exert its protective effect by restoring all the parameters to normal and disappearance of cysts in ovaries. Conclusion: Curcumin showed beneficial effects in Letrozole induced PCOS in female Wistar rats. Its effect was comparable to that of Clomiphene citrate, most widely used treatment for ovulation induction in PCOS condition.http://www.sciencedirect.com/science/article/pii/S2305050016000154PCOSLetrozoleCurcuminCysts
spellingShingle P. Sushma Reddy
Nazia Begum
Sumith Mutha
Vasudha Bakshi
Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome
Asian Pacific Journal of Reproduction
PCOS
Letrozole
Curcumin
Cysts
title Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome
title_full Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome
title_fullStr Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome
title_full_unstemmed Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome
title_short Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome
title_sort beneficial effect of curcumin in letrozole induced polycystic ovary syndrome
topic PCOS
Letrozole
Curcumin
Cysts
url http://www.sciencedirect.com/science/article/pii/S2305050016000154
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AT naziabegum beneficialeffectofcurcumininletrozoleinducedpolycysticovarysyndrome
AT sumithmutha beneficialeffectofcurcumininletrozoleinducedpolycysticovarysyndrome
AT vasudhabakshi beneficialeffectofcurcumininletrozoleinducedpolycysticovarysyndrome