Painful diabetic neuropathy: The role of ion channels
Painful diabetic neuropathy (PDN) is a common chronic complication of diabetes that causes neuropathic pain and negatively affects the quality of life. The management of PDN is far from satisfactory. At present, interventions are primarily focused on symptomatic treatment. Ion channel disorders are...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332224003019 |
| _version_ | 1797248392985837568 |
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| author | Qi Wang Yifei Ye Linghui Yang Lifan Xiao Jin Liu Wensheng Zhang Guizhi Du |
| author_facet | Qi Wang Yifei Ye Linghui Yang Lifan Xiao Jin Liu Wensheng Zhang Guizhi Du |
| author_sort | Qi Wang |
| collection | DOAJ |
| description | Painful diabetic neuropathy (PDN) is a common chronic complication of diabetes that causes neuropathic pain and negatively affects the quality of life. The management of PDN is far from satisfactory. At present, interventions are primarily focused on symptomatic treatment. Ion channel disorders are a major cause of PDN, and a complete understanding of their roles and mechanisms may provide better options for the clinical treatment of PDN. Therefore, this review summarizes the important role of ion channels in PDN and the current drug development targeting these ion channels. |
| first_indexed | 2024-04-24T20:13:52Z |
| format | Article |
| id | doaj.art-1a1c457bfe7e4522aeb6e4e9d1d104d4 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-24T20:13:52Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-1a1c457bfe7e4522aeb6e4e9d1d104d42024-03-23T06:23:05ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-04-01173116417Painful diabetic neuropathy: The role of ion channelsQi Wang0Yifei Ye1Linghui Yang2Lifan Xiao3Jin Liu4Wensheng Zhang5Guizhi Du6Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Centre, West China Hospital, Sichuan University, Chengdu, China; National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Centre, West China Hospital, Sichuan University, Chengdu, China; National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Centre, West China Hospital, Sichuan University, Chengdu, China; National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Centre, West China Hospital, Sichuan University, Chengdu, China; National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Centre, West China Hospital, Sichuan University, Chengdu, China; National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Centre, West China Hospital, Sichuan University, Chengdu, China; National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China; Corresponding authors at: Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Centre, West China Hospital, Sichuan University, Chengdu, China.Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Centre, West China Hospital, Sichuan University, Chengdu, China; National-Local Joint Engineering Research Center of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China; Corresponding authors at: Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Centre, West China Hospital, Sichuan University, Chengdu, China.Painful diabetic neuropathy (PDN) is a common chronic complication of diabetes that causes neuropathic pain and negatively affects the quality of life. The management of PDN is far from satisfactory. At present, interventions are primarily focused on symptomatic treatment. Ion channel disorders are a major cause of PDN, and a complete understanding of their roles and mechanisms may provide better options for the clinical treatment of PDN. Therefore, this review summarizes the important role of ion channels in PDN and the current drug development targeting these ion channels.http://www.sciencedirect.com/science/article/pii/S0753332224003019Painful diabetic neuropathyIon channelsNeuropathic painMechanismsDrug |
| spellingShingle | Qi Wang Yifei Ye Linghui Yang Lifan Xiao Jin Liu Wensheng Zhang Guizhi Du Painful diabetic neuropathy: The role of ion channels Biomedicine & Pharmacotherapy Painful diabetic neuropathy Ion channels Neuropathic pain Mechanisms Drug |
| title | Painful diabetic neuropathy: The role of ion channels |
| title_full | Painful diabetic neuropathy: The role of ion channels |
| title_fullStr | Painful diabetic neuropathy: The role of ion channels |
| title_full_unstemmed | Painful diabetic neuropathy: The role of ion channels |
| title_short | Painful diabetic neuropathy: The role of ion channels |
| title_sort | painful diabetic neuropathy the role of ion channels |
| topic | Painful diabetic neuropathy Ion channels Neuropathic pain Mechanisms Drug |
| url | http://www.sciencedirect.com/science/article/pii/S0753332224003019 |
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