Where Dopaminergic and Cholinergic Systems Interact: A Gateway for Tuning Neurodegenerative Disorders
Historically, many investigations into neurodegenerative diseases have focused on alterations in specific neuronal populations such as, for example, the loss of midbrain dopaminergic neurons in Parkinson’s disease (PD) and loss of cholinergic transmission in Alzheimer’s disease (AD). However, it has...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-07-01
|
| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.661973/full |
| _version_ | 1818921743383789568 |
|---|---|
| author | Marianne Amalric Tommy Pattij Ioannis Sotiropoulos Ioannis Sotiropoulos Joana M. Silva Joana M. Silva Nuno Sousa Samira Ztaou Samira Ztaou Cristiano Chiamulera Lars U. Wahlberg Dwaine F. Emerich Giovanna Paolone |
| author_facet | Marianne Amalric Tommy Pattij Ioannis Sotiropoulos Ioannis Sotiropoulos Joana M. Silva Joana M. Silva Nuno Sousa Samira Ztaou Samira Ztaou Cristiano Chiamulera Lars U. Wahlberg Dwaine F. Emerich Giovanna Paolone |
| author_sort | Marianne Amalric |
| collection | DOAJ |
| description | Historically, many investigations into neurodegenerative diseases have focused on alterations in specific neuronal populations such as, for example, the loss of midbrain dopaminergic neurons in Parkinson’s disease (PD) and loss of cholinergic transmission in Alzheimer’s disease (AD). However, it has become increasingly clear that mammalian brain activities, from executive and motor functioning to memory and emotional responses, are strictly regulated by the integrity of multiple interdependent neuronal circuits. Among subcortical structures, the dopaminergic nigrostriatal and mesolimbic pathways as well as cholinergic innervation from basal forebrain and brainstem, play pivotal roles in orchestrating cognitive and non-cognitive symptoms in PD and AD. Understanding the functional interactions of these circuits and the consequent neurological changes that occur during degeneration provides new opportunities to understand the fundamental inter-workings of the human brain as well as develop new potential treatments for patients with dysfunctional neuronal circuits. Here, excerpted from a session of the European Behavioral Pharmacology Society meeting (Braga, Portugal, August 2019), we provide an update on our recent work in behavioral and cellular neuroscience that primarily focuses on interactions between cholinergic and dopaminergic systems in PD models, as well as stress in AD. These brief discussions include descriptions of (1) striatal cholinergic interneurons (CINs) and PD, (2) dopaminergic and cholinergic modulation of impulse control, and (3) the use of an implantable cell-based system for drug delivery directly the into brain and (4) the mechanisms through which day life stress, a risk factor for AD, damage protein and RNA homeostasis leading to AD neuronal malfunction. |
| first_indexed | 2024-12-20T01:42:30Z |
| format | Article |
| id | doaj.art-1a1cb78aa5534788b38d1b808aa46a71 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-20T01:42:30Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-1a1cb78aa5534788b38d1b808aa46a712022-12-21T19:57:51ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532021-07-011510.3389/fnbeh.2021.661973661973Where Dopaminergic and Cholinergic Systems Interact: A Gateway for Tuning Neurodegenerative DisordersMarianne Amalric0Tommy Pattij1Ioannis Sotiropoulos2Ioannis Sotiropoulos3Joana M. Silva4Joana M. Silva5Nuno Sousa6Samira Ztaou7Samira Ztaou8Cristiano Chiamulera9Lars U. Wahlberg10Dwaine F. Emerich11Giovanna Paolone12Centre National de la Recherche Scientifique (CNRS), UMR 7291, Laboratoire de Neurosciences Cognitives, Aix-Marseille University (AMU), Marseille, FranceAmsterdam Neuroscience, Department of Anatomy and Neurosciences, Amsterdam University Medical Centers, Amsterdam, NetherlandsLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s – PT Government Associate Laboratory, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, PortugalICVS/3B’s – PT Government Associate Laboratory, Braga, PortugalICVS/3B’s – PT Government Associate Laboratory, Braga, PortugalCentre National de la Recherche Scientifique (CNRS), UMR 7291, Laboratoire de Neurosciences Cognitives, Aix-Marseille University (AMU), Marseille, FranceDepartment of Molecular Therapeutics, New York State Psychiatric Institute, Department of Psychiatry, Columbia University, New York, NY, United StatesDepartment of Diagnostic and Public Health, Section of Pharmacology, University of Verona, Verona, ItalyGloriana Therapeutics, Inc., Warren, RI, United StatesIndependent Researcher, Glocester, RI, United StatesDepartment of Diagnostic and Public Health, Section of Pharmacology, University of Verona, Verona, ItalyHistorically, many investigations into neurodegenerative diseases have focused on alterations in specific neuronal populations such as, for example, the loss of midbrain dopaminergic neurons in Parkinson’s disease (PD) and loss of cholinergic transmission in Alzheimer’s disease (AD). However, it has become increasingly clear that mammalian brain activities, from executive and motor functioning to memory and emotional responses, are strictly regulated by the integrity of multiple interdependent neuronal circuits. Among subcortical structures, the dopaminergic nigrostriatal and mesolimbic pathways as well as cholinergic innervation from basal forebrain and brainstem, play pivotal roles in orchestrating cognitive and non-cognitive symptoms in PD and AD. Understanding the functional interactions of these circuits and the consequent neurological changes that occur during degeneration provides new opportunities to understand the fundamental inter-workings of the human brain as well as develop new potential treatments for patients with dysfunctional neuronal circuits. Here, excerpted from a session of the European Behavioral Pharmacology Society meeting (Braga, Portugal, August 2019), we provide an update on our recent work in behavioral and cellular neuroscience that primarily focuses on interactions between cholinergic and dopaminergic systems in PD models, as well as stress in AD. These brief discussions include descriptions of (1) striatal cholinergic interneurons (CINs) and PD, (2) dopaminergic and cholinergic modulation of impulse control, and (3) the use of an implantable cell-based system for drug delivery directly the into brain and (4) the mechanisms through which day life stress, a risk factor for AD, damage protein and RNA homeostasis leading to AD neuronal malfunction.https://www.frontiersin.org/articles/10.3389/fnbeh.2021.661973/fullacetylcholinedopamineAlzheimer’s and Parkinson’s diseaseimpulse controlencapsulated cell-based system |
| spellingShingle | Marianne Amalric Tommy Pattij Ioannis Sotiropoulos Ioannis Sotiropoulos Joana M. Silva Joana M. Silva Nuno Sousa Samira Ztaou Samira Ztaou Cristiano Chiamulera Lars U. Wahlberg Dwaine F. Emerich Giovanna Paolone Where Dopaminergic and Cholinergic Systems Interact: A Gateway for Tuning Neurodegenerative Disorders Frontiers in Behavioral Neuroscience acetylcholine dopamine Alzheimer’s and Parkinson’s disease impulse control encapsulated cell-based system |
| title | Where Dopaminergic and Cholinergic Systems Interact: A Gateway for Tuning Neurodegenerative Disorders |
| title_full | Where Dopaminergic and Cholinergic Systems Interact: A Gateway for Tuning Neurodegenerative Disorders |
| title_fullStr | Where Dopaminergic and Cholinergic Systems Interact: A Gateway for Tuning Neurodegenerative Disorders |
| title_full_unstemmed | Where Dopaminergic and Cholinergic Systems Interact: A Gateway for Tuning Neurodegenerative Disorders |
| title_short | Where Dopaminergic and Cholinergic Systems Interact: A Gateway for Tuning Neurodegenerative Disorders |
| title_sort | where dopaminergic and cholinergic systems interact a gateway for tuning neurodegenerative disorders |
| topic | acetylcholine dopamine Alzheimer’s and Parkinson’s disease impulse control encapsulated cell-based system |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2021.661973/full |
| work_keys_str_mv | AT marianneamalric wheredopaminergicandcholinergicsystemsinteractagatewayfortuningneurodegenerativedisorders AT tommypattij wheredopaminergicandcholinergicsystemsinteractagatewayfortuningneurodegenerativedisorders AT ioannissotiropoulos wheredopaminergicandcholinergicsystemsinteractagatewayfortuningneurodegenerativedisorders AT ioannissotiropoulos wheredopaminergicandcholinergicsystemsinteractagatewayfortuningneurodegenerativedisorders AT joanamsilva wheredopaminergicandcholinergicsystemsinteractagatewayfortuningneurodegenerativedisorders AT joanamsilva wheredopaminergicandcholinergicsystemsinteractagatewayfortuningneurodegenerativedisorders AT nunosousa wheredopaminergicandcholinergicsystemsinteractagatewayfortuningneurodegenerativedisorders AT samiraztaou wheredopaminergicandcholinergicsystemsinteractagatewayfortuningneurodegenerativedisorders AT samiraztaou wheredopaminergicandcholinergicsystemsinteractagatewayfortuningneurodegenerativedisorders AT cristianochiamulera wheredopaminergicandcholinergicsystemsinteractagatewayfortuningneurodegenerativedisorders AT larsuwahlberg wheredopaminergicandcholinergicsystemsinteractagatewayfortuningneurodegenerativedisorders AT dwainefemerich wheredopaminergicandcholinergicsystemsinteractagatewayfortuningneurodegenerativedisorders AT giovannapaolone wheredopaminergicandcholinergicsystemsinteractagatewayfortuningneurodegenerativedisorders |