Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses
The cellular heterogeneity of breast cancers still represents a major therapeutic challenge. The latest genomic studies have classified breast cancers in distinct clusters to inform the therapeutic approaches and predict clinical outcomes. The mammary epithelium is composed of luminal and basal cell...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-12-01
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| Series: | Neoplasia: An International Journal for Oncology Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S147655862030155X |
| _version_ | 1818666211569827840 |
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| author | Sebastien Taurin Haifa Alkhalifa |
| author_facet | Sebastien Taurin Haifa Alkhalifa |
| author_sort | Sebastien Taurin |
| collection | DOAJ |
| description | The cellular heterogeneity of breast cancers still represents a major therapeutic challenge. The latest genomic studies have classified breast cancers in distinct clusters to inform the therapeutic approaches and predict clinical outcomes. The mammary epithelium is composed of luminal and basal cells, and this seemingly hierarchical organization is dependent on various stem cells and progenitors populating the mammary gland. Some cancer cells are conceptually similar to the stem cells as they can self-renew and generate bulk populations of nontumorigenic cells. Two models have been proposed to explain the cell of origin of breast cancer and involve either the reprogramming of differentiated mammary cells or the dysregulation of mammary stem cells or progenitors. Both hypotheses are not exclusive and imply the accumulation of independent mutational events. Cancer stem cells have been isolated from breast tumors and implicated in the development, metastasis, and recurrence of breast cancers. Recent advances in single-cell sequencing help deciphering the clonal evolution within each breast tumor. Still, few clinical trials have been focused on these specific cancer cell populations. |
| first_indexed | 2024-12-17T06:00:56Z |
| format | Article |
| id | doaj.art-1a1cbb98f8c741a483e7e42eaa07410b |
| institution | Directory Open Access Journal |
| issn | 1476-5586 |
| language | English |
| last_indexed | 2024-12-17T06:00:56Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neoplasia: An International Journal for Oncology Research |
| spelling | doaj.art-1a1cbb98f8c741a483e7e42eaa07410b2022-12-21T22:00:54ZengElsevierNeoplasia: An International Journal for Oncology Research1476-55862020-12-012212663678Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypothesesSebastien Taurin0Haifa Alkhalifa1Department of Molecular Medicine, College of Medicine and Medical Sciences, Princess Al-Jawhara Center for Molecular Medicine and Inherited Disorders, Arabian Gulf University, Manama, Bahrain; Corresponding author.New York University Abu Dhabi, Abu Dhabi, United Arab EmiratesThe cellular heterogeneity of breast cancers still represents a major therapeutic challenge. The latest genomic studies have classified breast cancers in distinct clusters to inform the therapeutic approaches and predict clinical outcomes. The mammary epithelium is composed of luminal and basal cells, and this seemingly hierarchical organization is dependent on various stem cells and progenitors populating the mammary gland. Some cancer cells are conceptually similar to the stem cells as they can self-renew and generate bulk populations of nontumorigenic cells. Two models have been proposed to explain the cell of origin of breast cancer and involve either the reprogramming of differentiated mammary cells or the dysregulation of mammary stem cells or progenitors. Both hypotheses are not exclusive and imply the accumulation of independent mutational events. Cancer stem cells have been isolated from breast tumors and implicated in the development, metastasis, and recurrence of breast cancers. Recent advances in single-cell sequencing help deciphering the clonal evolution within each breast tumor. Still, few clinical trials have been focused on these specific cancer cell populations.http://www.sciencedirect.com/science/article/pii/S147655862030155XMammary stem cellCancer stem cellCD44CD24ALDH |
| spellingShingle | Sebastien Taurin Haifa Alkhalifa Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses Neoplasia: An International Journal for Oncology Research Mammary stem cell Cancer stem cell CD44 CD24 ALDH |
| title | Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses |
| title_full | Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses |
| title_fullStr | Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses |
| title_full_unstemmed | Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses |
| title_short | Breast cancers, mammary stem cells, and cancer stem cells, characteristics, and hypotheses |
| title_sort | breast cancers mammary stem cells and cancer stem cells characteristics and hypotheses |
| topic | Mammary stem cell Cancer stem cell CD44 CD24 ALDH |
| url | http://www.sciencedirect.com/science/article/pii/S147655862030155X |
| work_keys_str_mv | AT sebastientaurin breastcancersmammarystemcellsandcancerstemcellscharacteristicsandhypotheses AT haifaalkhalifa breastcancersmammarystemcellsandcancerstemcellscharacteristicsandhypotheses |