Bilateral Diffuse Nodular Pulmonary Ossification Mimicking Metastatic Disease in a Patient with Fibrolamellar Hepatocellular Carcinoma
Pulmonary ossification (PO) is a rare finding, characterized by mature bone formation in the lung parenchyma. We report a 20-year-old female patient diagnosed with fibrolamellar hepatocellular carcinoma (FL-HCC) and bilateral diffuse nodular PO. The patient presented with a unifocal left liver mass...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/8/3/226 |
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| author | Pattamon Sutthatarn Cara E. Morin Jessica Gartrell Wayne L. Furman Max R. Langham Teresa Santiago Andrew J. Murphy |
| author_facet | Pattamon Sutthatarn Cara E. Morin Jessica Gartrell Wayne L. Furman Max R. Langham Teresa Santiago Andrew J. Murphy |
| author_sort | Pattamon Sutthatarn |
| collection | DOAJ |
| description | Pulmonary ossification (PO) is a rare finding, characterized by mature bone formation in the lung parenchyma. We report a 20-year-old female patient diagnosed with fibrolamellar hepatocellular carcinoma (FL-HCC) and bilateral diffuse nodular PO. The patient presented with a unifocal left liver mass and multiple bilateral pulmonary lesions, which were treated as metastatic disease. The patient received neoadjuvant chemotherapy, followed by left hepatectomy, and bilateral staged thoracotomies for clearance of the pulmonary disease. The histology of the pulmonary nodules demonstrated nodular type PO. We present the history, the course of treatment, imaging, and histologic findings of this rare disease process that could mimic metastatic pulmonary disease. |
| first_indexed | 2024-03-10T13:11:18Z |
| format | Article |
| id | doaj.art-1a1d89f447044ab793fd7811e8fab248 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T13:11:18Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-1a1d89f447044ab793fd7811e8fab2482023-11-21T10:44:08ZengMDPI AGChildren2227-90672021-03-018322610.3390/children8030226Bilateral Diffuse Nodular Pulmonary Ossification Mimicking Metastatic Disease in a Patient with Fibrolamellar Hepatocellular CarcinomaPattamon Sutthatarn0Cara E. Morin1Jessica Gartrell2Wayne L. Furman3Max R. Langham4Teresa Santiago5Andrew J. Murphy6Department of Surgery, St. Jude Children’s Research Hospital, Memphis, TN 38105, USADepartment of Diagnostic Imaging, St. Jude Children’s Research Hospital, Memphis, TN 38105, USADepartment of Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USADepartment of Oncology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USADepartment of Surgery, St. Jude Children’s Research Hospital, Memphis, TN 38105, USADepartment of Pathology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USADepartment of Surgery, St. Jude Children’s Research Hospital, Memphis, TN 38105, USAPulmonary ossification (PO) is a rare finding, characterized by mature bone formation in the lung parenchyma. We report a 20-year-old female patient diagnosed with fibrolamellar hepatocellular carcinoma (FL-HCC) and bilateral diffuse nodular PO. The patient presented with a unifocal left liver mass and multiple bilateral pulmonary lesions, which were treated as metastatic disease. The patient received neoadjuvant chemotherapy, followed by left hepatectomy, and bilateral staged thoracotomies for clearance of the pulmonary disease. The histology of the pulmonary nodules demonstrated nodular type PO. We present the history, the course of treatment, imaging, and histologic findings of this rare disease process that could mimic metastatic pulmonary disease.https://www.mdpi.com/2227-9067/8/3/226diffuse nodular pulmonary ossificationfibrolamellar hepatocellular carcinomapulmonary calcification |
| spellingShingle | Pattamon Sutthatarn Cara E. Morin Jessica Gartrell Wayne L. Furman Max R. Langham Teresa Santiago Andrew J. Murphy Bilateral Diffuse Nodular Pulmonary Ossification Mimicking Metastatic Disease in a Patient with Fibrolamellar Hepatocellular Carcinoma Children diffuse nodular pulmonary ossification fibrolamellar hepatocellular carcinoma pulmonary calcification |
| title | Bilateral Diffuse Nodular Pulmonary Ossification Mimicking Metastatic Disease in a Patient with Fibrolamellar Hepatocellular Carcinoma |
| title_full | Bilateral Diffuse Nodular Pulmonary Ossification Mimicking Metastatic Disease in a Patient with Fibrolamellar Hepatocellular Carcinoma |
| title_fullStr | Bilateral Diffuse Nodular Pulmonary Ossification Mimicking Metastatic Disease in a Patient with Fibrolamellar Hepatocellular Carcinoma |
| title_full_unstemmed | Bilateral Diffuse Nodular Pulmonary Ossification Mimicking Metastatic Disease in a Patient with Fibrolamellar Hepatocellular Carcinoma |
| title_short | Bilateral Diffuse Nodular Pulmonary Ossification Mimicking Metastatic Disease in a Patient with Fibrolamellar Hepatocellular Carcinoma |
| title_sort | bilateral diffuse nodular pulmonary ossification mimicking metastatic disease in a patient with fibrolamellar hepatocellular carcinoma |
| topic | diffuse nodular pulmonary ossification fibrolamellar hepatocellular carcinoma pulmonary calcification |
| url | https://www.mdpi.com/2227-9067/8/3/226 |
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