Zygotic Vsx1 Plays a Key Role in Defining V2a Interneuron Sub-Lineage by Directly Repressing <i>tal1</i> Transcription in Zebrafish

Zygotic Vsx1 Plays a Key Role in Defining V2a Interneuron Sub-Lineage by Directly Repressing <i>tal1</i> Transcription in Zebrafish

In the spinal cord, excitatory V2a and inhibitory V2b interneurons are produced together by the final division of common P2 progenitors. During V2a and V2b diversification, Tal1 is necessary and sufficient to promote V2b differentiation and Vsx2 suppresses the expression of motor neuron genes to con...

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Bibliographic Details
Main Authors: Qi Zhang, Haomang Xu, Wei Zhao, Jianbo Zheng, Lei Sun, Chen Luo
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
V2 interneuron diversification
V2a interneuron specification
Vsx1
Tal1
transcriptional repression
spinal cord
Online Access:https://www.mdpi.com/1422-0067/21/10/3600

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