Changes in Rats’ Gut Microbiota Composition Caused by Induced Chronic Myocardial Infarction Lead to Depression-Like Behavior
Depression is common among patients who have chronic myocardial infarction (CMI). Despite their frequency, depression and CMI are bidirectional related conditions, each is a risk for the other, and they often co-exist, suggesting shared or interacting pathomechanisms. Accumulating data revealed the...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.641084/full |
| _version_ | 1818059646283284480 |
|---|---|
| author | Qianwen Wang Xi Wang Xi Wang Xi Wang Yong Lv Chun Yang Chenliang Zhou Long Wang |
| author_facet | Qianwen Wang Xi Wang Xi Wang Xi Wang Yong Lv Chun Yang Chenliang Zhou Long Wang |
| author_sort | Qianwen Wang |
| collection | DOAJ |
| description | Depression is common among patients who have chronic myocardial infarction (CMI). Despite their frequency, depression and CMI are bidirectional related conditions, each is a risk for the other, and they often co-exist, suggesting shared or interacting pathomechanisms. Accumulating data revealed the effects of gut microbiota in terms of regulating depression via the gut–brain axis. Thus, we investigated the role of gut microbial dysbiosis in CMI-induced depression-like behavior. Hierarchical cluster analysis of sucrose preference test (SPT) results was adopted to classify the CMI rats into depression-like behavior (CMI + Dep) or non-depression-like behavior (CMI + Non-Dep) phenotypes. First, 16S ribosomal RNA sequencing analysis showed both β-diversity and relative abundance of several gut bacteria significantly differed between the CMI + Dep and CMI + Non-Dep rats. Next, transplantation of fecal microbiota from CMI + Dep rats visibly altered the relative abundance of gut microbiota and also induced depression-like behavior in the antibiotics-treated pseudo-germ-free rats. In conclusion, these findings suggested that dysbiosis in gut microbial composition contributed to the onset of CMI-induced depression-like behavior and that exogenous regulation of gut microbiota composition could be a potential therapeutic strategy for CMI and related depression-like behavior. |
| first_indexed | 2024-12-10T13:19:50Z |
| format | Article |
| id | doaj.art-1a20f14810ce483da6b63d2271488c95 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-10T13:19:50Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-1a20f14810ce483da6b63d2271488c952022-12-22T01:47:23ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-04-011210.3389/fmicb.2021.641084641084Changes in Rats’ Gut Microbiota Composition Caused by Induced Chronic Myocardial Infarction Lead to Depression-Like BehaviorQianwen Wang0Xi Wang1Xi Wang2Xi Wang3Yong Lv4Chun Yang5Chenliang Zhou6Long Wang7Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Cardiology, Renmin Hospital of Wuhan University, Wuhan, ChinaCardiovascular Research Institute, Wuhan University, Wuhan, ChinaHubei Key Laboratory of Cardiology, Wuhan, ChinaDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, ChinaDepression is common among patients who have chronic myocardial infarction (CMI). Despite their frequency, depression and CMI are bidirectional related conditions, each is a risk for the other, and they often co-exist, suggesting shared or interacting pathomechanisms. Accumulating data revealed the effects of gut microbiota in terms of regulating depression via the gut–brain axis. Thus, we investigated the role of gut microbial dysbiosis in CMI-induced depression-like behavior. Hierarchical cluster analysis of sucrose preference test (SPT) results was adopted to classify the CMI rats into depression-like behavior (CMI + Dep) or non-depression-like behavior (CMI + Non-Dep) phenotypes. First, 16S ribosomal RNA sequencing analysis showed both β-diversity and relative abundance of several gut bacteria significantly differed between the CMI + Dep and CMI + Non-Dep rats. Next, transplantation of fecal microbiota from CMI + Dep rats visibly altered the relative abundance of gut microbiota and also induced depression-like behavior in the antibiotics-treated pseudo-germ-free rats. In conclusion, these findings suggested that dysbiosis in gut microbial composition contributed to the onset of CMI-induced depression-like behavior and that exogenous regulation of gut microbiota composition could be a potential therapeutic strategy for CMI and related depression-like behavior.https://www.frontiersin.org/articles/10.3389/fmicb.2021.641084/fullchronic myocardial infarctiongut microbiotadepression-like behaviormicrobiome-gut-brain axishierarchical cluster analysis |
| spellingShingle | Qianwen Wang Xi Wang Xi Wang Xi Wang Yong Lv Chun Yang Chenliang Zhou Long Wang Changes in Rats’ Gut Microbiota Composition Caused by Induced Chronic Myocardial Infarction Lead to Depression-Like Behavior Frontiers in Microbiology chronic myocardial infarction gut microbiota depression-like behavior microbiome-gut-brain axis hierarchical cluster analysis |
| title | Changes in Rats’ Gut Microbiota Composition Caused by Induced Chronic Myocardial Infarction Lead to Depression-Like Behavior |
| title_full | Changes in Rats’ Gut Microbiota Composition Caused by Induced Chronic Myocardial Infarction Lead to Depression-Like Behavior |
| title_fullStr | Changes in Rats’ Gut Microbiota Composition Caused by Induced Chronic Myocardial Infarction Lead to Depression-Like Behavior |
| title_full_unstemmed | Changes in Rats’ Gut Microbiota Composition Caused by Induced Chronic Myocardial Infarction Lead to Depression-Like Behavior |
| title_short | Changes in Rats’ Gut Microbiota Composition Caused by Induced Chronic Myocardial Infarction Lead to Depression-Like Behavior |
| title_sort | changes in rats gut microbiota composition caused by induced chronic myocardial infarction lead to depression like behavior |
| topic | chronic myocardial infarction gut microbiota depression-like behavior microbiome-gut-brain axis hierarchical cluster analysis |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.641084/full |
| work_keys_str_mv | AT qianwenwang changesinratsgutmicrobiotacompositioncausedbyinducedchronicmyocardialinfarctionleadtodepressionlikebehavior AT xiwang changesinratsgutmicrobiotacompositioncausedbyinducedchronicmyocardialinfarctionleadtodepressionlikebehavior AT xiwang changesinratsgutmicrobiotacompositioncausedbyinducedchronicmyocardialinfarctionleadtodepressionlikebehavior AT xiwang changesinratsgutmicrobiotacompositioncausedbyinducedchronicmyocardialinfarctionleadtodepressionlikebehavior AT yonglv changesinratsgutmicrobiotacompositioncausedbyinducedchronicmyocardialinfarctionleadtodepressionlikebehavior AT chunyang changesinratsgutmicrobiotacompositioncausedbyinducedchronicmyocardialinfarctionleadtodepressionlikebehavior AT chenliangzhou changesinratsgutmicrobiotacompositioncausedbyinducedchronicmyocardialinfarctionleadtodepressionlikebehavior AT longwang changesinratsgutmicrobiotacompositioncausedbyinducedchronicmyocardialinfarctionleadtodepressionlikebehavior |