The DosS-DosT/DosR Mycobacterial Sensor System
DosS/DosR is a two-component regulatory system in which DosS, a heme-containing sensor also known as DevS, under certain conditions undergoes autophosphorylation and then transfers the phosphate to DosR, a DNA-binding protein that controls the entry of Mycobacterium tuberculosis and other mycobacter...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-07-01
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| Series: | Biosensors |
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| Online Access: | http://www.mdpi.com/2079-6374/3/3/259 |
| _version_ | 1818136093243998208 |
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| author | Santhosh Sivaramakrishnan Paul R. Ortiz de Montellano |
| author_facet | Santhosh Sivaramakrishnan Paul R. Ortiz de Montellano |
| author_sort | Santhosh Sivaramakrishnan |
| collection | DOAJ |
| description | DosS/DosR is a two-component regulatory system in which DosS, a heme-containing sensor also known as DevS, under certain conditions undergoes autophosphorylation and then transfers the phosphate to DosR, a DNA-binding protein that controls the entry of Mycobacterium tuberculosis and other mycobacteria into a latent, dormant state. DosT, a second sensor closely related to DosS, is present in M. tuberculosis and participates in the control of the dormancy response mediated by DosR. The binding of phosphorylated DosR to DNA initiates the expression of approximately fifty dormancy-linked genes. DosT is accepted to be a gas sensor that is activated in the ferrous state by the absence of an oxygen ligand or by the binding of NO or CO. DosS functions in a similar fashion as a gas sensor, but contradictory evidence has led to the suggestion that it also functions as a redox state sensor. This review focuses on the structure, biophysical properties, and function of the DosS/DosT heme sensors. |
| first_indexed | 2024-12-11T09:34:55Z |
| format | Article |
| id | doaj.art-1a222810d5e449dc948136c7c86eff93 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-12-11T09:34:55Z |
| publishDate | 2013-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-1a222810d5e449dc948136c7c86eff932022-12-22T01:12:54ZengMDPI AGBiosensors2079-63742013-07-013325928210.3390/bios3030259The DosS-DosT/DosR Mycobacterial Sensor SystemSanthosh SivaramakrishnanPaul R. Ortiz de MontellanoDosS/DosR is a two-component regulatory system in which DosS, a heme-containing sensor also known as DevS, under certain conditions undergoes autophosphorylation and then transfers the phosphate to DosR, a DNA-binding protein that controls the entry of Mycobacterium tuberculosis and other mycobacteria into a latent, dormant state. DosT, a second sensor closely related to DosS, is present in M. tuberculosis and participates in the control of the dormancy response mediated by DosR. The binding of phosphorylated DosR to DNA initiates the expression of approximately fifty dormancy-linked genes. DosT is accepted to be a gas sensor that is activated in the ferrous state by the absence of an oxygen ligand or by the binding of NO or CO. DosS functions in a similar fashion as a gas sensor, but contradictory evidence has led to the suggestion that it also functions as a redox state sensor. This review focuses on the structure, biophysical properties, and function of the DosS/DosT heme sensors.http://www.mdpi.com/2079-6374/3/3/259DevSDosSDosTDosRMycobacterium tuberculosisheme-based sensorstwo-component systemnitric oxidecarbon monoxidehypoxiadormancy |
| spellingShingle | Santhosh Sivaramakrishnan Paul R. Ortiz de Montellano The DosS-DosT/DosR Mycobacterial Sensor System Biosensors DevS DosS DosT DosR Mycobacterium tuberculosis heme-based sensors two-component system nitric oxide carbon monoxide hypoxia dormancy |
| title | The DosS-DosT/DosR Mycobacterial Sensor System |
| title_full | The DosS-DosT/DosR Mycobacterial Sensor System |
| title_fullStr | The DosS-DosT/DosR Mycobacterial Sensor System |
| title_full_unstemmed | The DosS-DosT/DosR Mycobacterial Sensor System |
| title_short | The DosS-DosT/DosR Mycobacterial Sensor System |
| title_sort | doss dost dosr mycobacterial sensor system |
| topic | DevS DosS DosT DosR Mycobacterium tuberculosis heme-based sensors two-component system nitric oxide carbon monoxide hypoxia dormancy |
| url | http://www.mdpi.com/2079-6374/3/3/259 |
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