Seasonal influenza vaccine in immunocompromised persons
Immunocompromised persons are at high risk of complications from influenza infection. This population includes those with solid organ transplants, hematopoietic stem cell transplants, solid cancers and hematologic malignancy as well as those with autoimmune conditions receiving biologic therapies. I...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-06-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2018.1445446 |
| _version_ | 1797677456681861120 |
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| author | Mohammad Bosaeed Deepali Kumar |
| author_facet | Mohammad Bosaeed Deepali Kumar |
| author_sort | Mohammad Bosaeed |
| collection | DOAJ |
| description | Immunocompromised persons are at high risk of complications from influenza infection. This population includes those with solid organ transplants, hematopoietic stem cell transplants, solid cancers and hematologic malignancy as well as those with autoimmune conditions receiving biologic therapies. In this review, we discuss the impact of influenza infection and evidence for vaccine effectiveness and immunogenicity. Overall, lower respiratory disease from influenza is common; however, vaccine immunogenicity is low. Despite this, in some populations, influenza vaccine has demonstrated effectiveness in reducing severe disease. Various strategies to improve influenza vaccine immunogenicity have been attempted including two vaccine doses in the same influenza season, intradermal, adjuvanted, and high-dose vaccines. The timing of influenza vaccine is also important to achieve optimal immunogenicity. Given the suboptimal immunogenicity, family members and healthcare professionals involved in the care of these populations should be vaccinated. Health care professional recommendation for vaccination is an important factor in vaccine coverage. |
| first_indexed | 2024-03-11T22:45:27Z |
| format | Article |
| id | doaj.art-1a2251f062a1412885b5649ef885dc61 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:45:27Z |
| publishDate | 2018-06-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-1a2251f062a1412885b5649ef885dc612023-09-22T08:17:54ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2018-06-011461311132210.1080/21645515.2018.14454461445446Seasonal influenza vaccine in immunocompromised personsMohammad Bosaeed0Deepali Kumar1Transplant Infectious Diseases and Multi-Organ Transplant Program, University Health NetworkTransplant Infectious Diseases and Multi-Organ Transplant Program, University Health NetworkImmunocompromised persons are at high risk of complications from influenza infection. This population includes those with solid organ transplants, hematopoietic stem cell transplants, solid cancers and hematologic malignancy as well as those with autoimmune conditions receiving biologic therapies. In this review, we discuss the impact of influenza infection and evidence for vaccine effectiveness and immunogenicity. Overall, lower respiratory disease from influenza is common; however, vaccine immunogenicity is low. Despite this, in some populations, influenza vaccine has demonstrated effectiveness in reducing severe disease. Various strategies to improve influenza vaccine immunogenicity have been attempted including two vaccine doses in the same influenza season, intradermal, adjuvanted, and high-dose vaccines. The timing of influenza vaccine is also important to achieve optimal immunogenicity. Given the suboptimal immunogenicity, family members and healthcare professionals involved in the care of these populations should be vaccinated. Health care professional recommendation for vaccination is an important factor in vaccine coverage.http://dx.doi.org/10.1080/21645515.2018.1445446organ transplantstem cell transplanthematologic malignancybiologics |
| spellingShingle | Mohammad Bosaeed Deepali Kumar Seasonal influenza vaccine in immunocompromised persons Human Vaccines & Immunotherapeutics organ transplant stem cell transplant hematologic malignancy biologics |
| title | Seasonal influenza vaccine in immunocompromised persons |
| title_full | Seasonal influenza vaccine in immunocompromised persons |
| title_fullStr | Seasonal influenza vaccine in immunocompromised persons |
| title_full_unstemmed | Seasonal influenza vaccine in immunocompromised persons |
| title_short | Seasonal influenza vaccine in immunocompromised persons |
| title_sort | seasonal influenza vaccine in immunocompromised persons |
| topic | organ transplant stem cell transplant hematologic malignancy biologics |
| url | http://dx.doi.org/10.1080/21645515.2018.1445446 |
| work_keys_str_mv | AT mohammadbosaeed seasonalinfluenzavaccineinimmunocompromisedpersons AT deepalikumar seasonalinfluenzavaccineinimmunocompromisedpersons |