Biomimetic Cationic Nanoparticles Based on Silica: Optimizing Bilayer Deposition from Lipid Films
The optimization of bilayer coverage on particles is important for a variety of biomedical applications, such as drug, vaccine, and genetic material delivery. This work aims at optimizing the deposition of cationic bilayers on silica over a range of experimental conditions for the intervening medium...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-10-01
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| Series: | Biomimetics |
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| Online Access: | https://www.mdpi.com/2313-7673/2/4/20 |
| _version_ | 1811284404192935936 |
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| author | Rodrigo T. Ribeiro Victor H. A. Braga Ana M. Carmona-Ribeiro |
| author_facet | Rodrigo T. Ribeiro Victor H. A. Braga Ana M. Carmona-Ribeiro |
| author_sort | Rodrigo T. Ribeiro |
| collection | DOAJ |
| description | The optimization of bilayer coverage on particles is important for a variety of biomedical applications, such as drug, vaccine, and genetic material delivery. This work aims at optimizing the deposition of cationic bilayers on silica over a range of experimental conditions for the intervening medium and two different assemblies for the cationic lipid, namely, lipid films or pre-formed lipid bilayer fragments. The lipid adsorption on silica in situ over a range of added lipid concentrations was determined from elemental analysis of carbon, hydrogen, and nitrogen and related to the colloidal stability, sizing, zeta potential, and polydispersity of the silica/lipid nanoparticles. Superior bilayer deposition took place from lipid films, whereas adsorption from pre-formed bilayer fragments yielded limiting adsorption below the levels expected for bilayer adsorption. |
| first_indexed | 2024-04-13T02:28:08Z |
| format | Article |
| id | doaj.art-1a23109deb224f3b97d1d196eedc14e5 |
| institution | Directory Open Access Journal |
| issn | 2313-7673 |
| language | English |
| last_indexed | 2024-04-13T02:28:08Z |
| publishDate | 2017-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomimetics |
| spelling | doaj.art-1a23109deb224f3b97d1d196eedc14e52022-12-22T03:06:41ZengMDPI AGBiomimetics2313-76732017-10-01242010.3390/biomimetics2040020biomimetics2040020Biomimetic Cationic Nanoparticles Based on Silica: Optimizing Bilayer Deposition from Lipid FilmsRodrigo T. Ribeiro0Victor H. A. Braga1Ana M. Carmona-Ribeiro2Biocolloids Laboratory, Instituto de Química, Universidade de São Paulo, Av. Lineu Prestes 748, São Paulo 05508-000, SP, BrazilBiocolloids Laboratory, Instituto de Química, Universidade de São Paulo, Av. Lineu Prestes 748, São Paulo 05508-000, SP, BrazilBiocolloids Laboratory, Instituto de Química, Universidade de São Paulo, Av. Lineu Prestes 748, São Paulo 05508-000, SP, BrazilThe optimization of bilayer coverage on particles is important for a variety of biomedical applications, such as drug, vaccine, and genetic material delivery. This work aims at optimizing the deposition of cationic bilayers on silica over a range of experimental conditions for the intervening medium and two different assemblies for the cationic lipid, namely, lipid films or pre-formed lipid bilayer fragments. The lipid adsorption on silica in situ over a range of added lipid concentrations was determined from elemental analysis of carbon, hydrogen, and nitrogen and related to the colloidal stability, sizing, zeta potential, and polydispersity of the silica/lipid nanoparticles. Superior bilayer deposition took place from lipid films, whereas adsorption from pre-formed bilayer fragments yielded limiting adsorption below the levels expected for bilayer adsorption.https://www.mdpi.com/2313-7673/2/4/20AEROSIL OX-50dioctadecyldimethylammonium bromide N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chlorideelemental analysis for in situ adsorptioncolloidal stabilitycationic bilayer fragmentsfilms of cationic lipidsoptimal bilayer adsorption from films |
| spellingShingle | Rodrigo T. Ribeiro Victor H. A. Braga Ana M. Carmona-Ribeiro Biomimetic Cationic Nanoparticles Based on Silica: Optimizing Bilayer Deposition from Lipid Films Biomimetics AEROSIL OX-50 dioctadecyldimethylammonium bromide N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride elemental analysis for in situ adsorption colloidal stability cationic bilayer fragments films of cationic lipids optimal bilayer adsorption from films |
| title | Biomimetic Cationic Nanoparticles Based on Silica: Optimizing Bilayer Deposition from Lipid Films |
| title_full | Biomimetic Cationic Nanoparticles Based on Silica: Optimizing Bilayer Deposition from Lipid Films |
| title_fullStr | Biomimetic Cationic Nanoparticles Based on Silica: Optimizing Bilayer Deposition from Lipid Films |
| title_full_unstemmed | Biomimetic Cationic Nanoparticles Based on Silica: Optimizing Bilayer Deposition from Lipid Films |
| title_short | Biomimetic Cationic Nanoparticles Based on Silica: Optimizing Bilayer Deposition from Lipid Films |
| title_sort | biomimetic cationic nanoparticles based on silica optimizing bilayer deposition from lipid films |
| topic | AEROSIL OX-50 dioctadecyldimethylammonium bromide N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium chloride elemental analysis for in situ adsorption colloidal stability cationic bilayer fragments films of cationic lipids optimal bilayer adsorption from films |
| url | https://www.mdpi.com/2313-7673/2/4/20 |
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