Genetic basis for coordination of meiosis and sexual structure maturation in Cryptococcus neoformans
In the human fungal pathogen Cryptococcus neoformans, sex can benefit its pathogenicity through production of meiospores, which are believed to offer both physical and meiosis-created lineage advantages for its infections. Cryptococcus sporulation occurs following two parallel events, meiosis and di...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2018-10-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/38683 |
| _version_ | 1811180458949476352 |
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| author | Linxia Liu Guang-Jun He Lei Chen Jiao Zheng Yingying Chen Lan Shen Xiuyun Tian Erwei Li Ence Yang Guojian Liao Linqi Wang |
| author_facet | Linxia Liu Guang-Jun He Lei Chen Jiao Zheng Yingying Chen Lan Shen Xiuyun Tian Erwei Li Ence Yang Guojian Liao Linqi Wang |
| author_sort | Linxia Liu |
| collection | DOAJ |
| description | In the human fungal pathogen Cryptococcus neoformans, sex can benefit its pathogenicity through production of meiospores, which are believed to offer both physical and meiosis-created lineage advantages for its infections. Cryptococcus sporulation occurs following two parallel events, meiosis and differentiation of the basidium, the characteristic sexual structure of the basidiomycetes. However, the circuit integrating these events to ensure subsequent sporulation is unclear. Here, we show the spatiotemporal coordination of meiosis and basidial maturation by visualizing event-specific molecules in developing basidia defined by a quantitative approach. Monitoring of gene induction timing together with genetic analysis reveals co-regulation of the coordinated events by a shared regulatory program. Two RRM family regulators, Csa1 and Csa2, are crucial components that bridge meiosis and basidial maturation, further determining sporulation. We propose that the regulatory coordination of meiosis and basidial development serves as a determinant underlying the production of infectious meiospores in C. neoformans. |
| first_indexed | 2024-04-11T09:02:27Z |
| format | Article |
| id | doaj.art-1a25d2513f19498193211307b178ac36 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-11T09:02:27Z |
| publishDate | 2018-10-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-1a25d2513f19498193211307b178ac362022-12-22T04:32:43ZengeLife Sciences Publications LtdeLife2050-084X2018-10-01710.7554/eLife.38683Genetic basis for coordination of meiosis and sexual structure maturation in Cryptococcus neoformansLinxia Liu0Guang-Jun He1Lei Chen2Jiao Zheng3Yingying Chen4Lan Shen5Xiuyun Tian6Erwei Li7Ence Yang8Guojian Liao9Linqi Wang10https://orcid.org/0000-0002-5243-341XState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, ChinaCollege of Pharmaceutical Sciences, Southwest University, Chongqing, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, ChinaDepartment of Microbiology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, ChinaCollege of Pharmaceutical Sciences, Southwest University, Chongqing, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, ChinaIn the human fungal pathogen Cryptococcus neoformans, sex can benefit its pathogenicity through production of meiospores, which are believed to offer both physical and meiosis-created lineage advantages for its infections. Cryptococcus sporulation occurs following two parallel events, meiosis and differentiation of the basidium, the characteristic sexual structure of the basidiomycetes. However, the circuit integrating these events to ensure subsequent sporulation is unclear. Here, we show the spatiotemporal coordination of meiosis and basidial maturation by visualizing event-specific molecules in developing basidia defined by a quantitative approach. Monitoring of gene induction timing together with genetic analysis reveals co-regulation of the coordinated events by a shared regulatory program. Two RRM family regulators, Csa1 and Csa2, are crucial components that bridge meiosis and basidial maturation, further determining sporulation. We propose that the regulatory coordination of meiosis and basidial development serves as a determinant underlying the production of infectious meiospores in C. neoformans.https://elifesciences.org/articles/38683Cryptococcus neoformanssexual reproductionmorphotype transitionsporulation |
| spellingShingle | Linxia Liu Guang-Jun He Lei Chen Jiao Zheng Yingying Chen Lan Shen Xiuyun Tian Erwei Li Ence Yang Guojian Liao Linqi Wang Genetic basis for coordination of meiosis and sexual structure maturation in Cryptococcus neoformans eLife Cryptococcus neoformans sexual reproduction morphotype transition sporulation |
| title | Genetic basis for coordination of meiosis and sexual structure maturation in Cryptococcus neoformans |
| title_full | Genetic basis for coordination of meiosis and sexual structure maturation in Cryptococcus neoformans |
| title_fullStr | Genetic basis for coordination of meiosis and sexual structure maturation in Cryptococcus neoformans |
| title_full_unstemmed | Genetic basis for coordination of meiosis and sexual structure maturation in Cryptococcus neoformans |
| title_short | Genetic basis for coordination of meiosis and sexual structure maturation in Cryptococcus neoformans |
| title_sort | genetic basis for coordination of meiosis and sexual structure maturation in cryptococcus neoformans |
| topic | Cryptococcus neoformans sexual reproduction morphotype transition sporulation |
| url | https://elifesciences.org/articles/38683 |
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