Antiretroviral Drug Interactions: Overview of Interactions Involving New and Investigational Agents and the Role of Therapeutic Drug Monitoring for Management
Antiretrovirals are prone to drug-drug and drug-food interactions that can result in subtherapeutic or supratherapeutic concentrations. Interactions between antiretrovirals and medications for other diseases are common due to shared metabolism through cytochrome P450 (CYP450) and uridine diphosphate...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-10-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1999-4923/3/4/745/ |
| _version_ | 1798042578911756288 |
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| author | R. Chris Rathbun Michelle D. Liedtke |
| author_facet | R. Chris Rathbun Michelle D. Liedtke |
| author_sort | R. Chris Rathbun |
| collection | DOAJ |
| description | Antiretrovirals are prone to drug-drug and drug-food interactions that can result in subtherapeutic or supratherapeutic concentrations. Interactions between antiretrovirals and medications for other diseases are common due to shared metabolism through cytochrome P450 (CYP450) and uridine diphosphate glucuronosyltransferase (UGT) enzymes and transport by membrane proteins (e.g., p-glycoprotein, organic anion-transporting polypeptide). The clinical significance of antiretroviral drug interactions is reviewed, with a focus on new and investigational agents. An overview of the mechanistic basis for drug interactions and the effect of individual antiretrovirals on CYP450 and UGT isoforms are provided. Interactions between antiretrovirals and medications for other co-morbidities are summarized. The role of therapeutic drug monitoring in the detection and management of antiretroviral drug interactions is also briefly discussed. |
| first_indexed | 2024-04-11T22:37:30Z |
| format | Article |
| id | doaj.art-1a2724173b454335be0d39870e16cdf7 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T22:37:30Z |
| publishDate | 2011-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-1a2724173b454335be0d39870e16cdf72022-12-22T03:59:09ZengMDPI AGPharmaceutics1999-49232011-10-013474578110.3390/pharmaceutics3040745Antiretroviral Drug Interactions: Overview of Interactions Involving New and Investigational Agents and the Role of Therapeutic Drug Monitoring for ManagementR. Chris RathbunMichelle D. LiedtkeAntiretrovirals are prone to drug-drug and drug-food interactions that can result in subtherapeutic or supratherapeutic concentrations. Interactions between antiretrovirals and medications for other diseases are common due to shared metabolism through cytochrome P450 (CYP450) and uridine diphosphate glucuronosyltransferase (UGT) enzymes and transport by membrane proteins (e.g., p-glycoprotein, organic anion-transporting polypeptide). The clinical significance of antiretroviral drug interactions is reviewed, with a focus on new and investigational agents. An overview of the mechanistic basis for drug interactions and the effect of individual antiretrovirals on CYP450 and UGT isoforms are provided. Interactions between antiretrovirals and medications for other co-morbidities are summarized. The role of therapeutic drug monitoring in the detection and management of antiretroviral drug interactions is also briefly discussed.http://www.mdpi.com/1999-4923/3/4/745/antiretroviralspharmacokineticsdrug interactionsprotease inhibitorsnon-nucleoside reverse transcriptase inhibitorschemokine receptor antagonistsintegrase inhibitorstherapeutic drug monitoring |
| spellingShingle | R. Chris Rathbun Michelle D. Liedtke Antiretroviral Drug Interactions: Overview of Interactions Involving New and Investigational Agents and the Role of Therapeutic Drug Monitoring for Management Pharmaceutics antiretrovirals pharmacokinetics drug interactions protease inhibitors non-nucleoside reverse transcriptase inhibitors chemokine receptor antagonists integrase inhibitors therapeutic drug monitoring |
| title | Antiretroviral Drug Interactions: Overview of Interactions Involving New and Investigational Agents and the Role of Therapeutic Drug Monitoring for Management |
| title_full | Antiretroviral Drug Interactions: Overview of Interactions Involving New and Investigational Agents and the Role of Therapeutic Drug Monitoring for Management |
| title_fullStr | Antiretroviral Drug Interactions: Overview of Interactions Involving New and Investigational Agents and the Role of Therapeutic Drug Monitoring for Management |
| title_full_unstemmed | Antiretroviral Drug Interactions: Overview of Interactions Involving New and Investigational Agents and the Role of Therapeutic Drug Monitoring for Management |
| title_short | Antiretroviral Drug Interactions: Overview of Interactions Involving New and Investigational Agents and the Role of Therapeutic Drug Monitoring for Management |
| title_sort | antiretroviral drug interactions overview of interactions involving new and investigational agents and the role of therapeutic drug monitoring for management |
| topic | antiretrovirals pharmacokinetics drug interactions protease inhibitors non-nucleoside reverse transcriptase inhibitors chemokine receptor antagonists integrase inhibitors therapeutic drug monitoring |
| url | http://www.mdpi.com/1999-4923/3/4/745/ |
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