Monocarboxylate Transporter 4 in Cancer-Associated Fibroblasts Is a Driver of Aggressiveness in Aerodigestive Tract Cancers

Monocarboxylate Transporter 4 in Cancer-Associated Fibroblasts Is a Driver of Aggressiveness in Aerodigestive Tract Cancers

The most common cancers of the aerodigestive tract (ADT) are non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC). The tumor stroma plays an important role in ADT cancer development and progression, and contributes to the metabolic heterogeneity of tumors. Cancer-asso...

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Bibliographic Details
Main Authors:	Marina Domingo-Vidal, Diana Whitaker-Menezes, Mehri Mollaee, Zhao Lin, Madalina Tuluc, Nancy Philp, Jennifer M. Johnson, Tingting Zhan, Joseph Curry, Ubaldo Martinez-Outschoorn
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Oncology
Subjects:	aerodigestive tract cancer non-small cell lung cancer head and neck squamous cell carcinoma cancer-associated fibroblast (CAF) metabolic compartmentalization monocarboxylate transporter 4 (MCT4)
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.906494/full

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