A Holistic Perspective on How Photobiomodulation May Influence Fatigue, Pain, and Depression in Inflammatory Bowel Disease: Beyond Molecular Mechanisms
Background: Numerous mechanisms, mostly molecular, have been tested and proposed for photobiomodulation. Photobiomodulation is finding a niche in the treatment of conditions that have no gold-standard treatment or only partially effective pharmacological treatment. Many chronic conditions are charac...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/11/5/1497 |
| _version_ | 1797600905353232384 |
|---|---|
| author | E-Liisa Laakso Tatjana Ewais |
| author_facet | E-Liisa Laakso Tatjana Ewais |
| author_sort | E-Liisa Laakso |
| collection | DOAJ |
| description | Background: Numerous mechanisms, mostly molecular, have been tested and proposed for photobiomodulation. Photobiomodulation is finding a niche in the treatment of conditions that have no gold-standard treatment or only partially effective pharmacological treatment. Many chronic conditions are characterised by symptoms for which there is no cure or control and for which pharmaceuticals may add to the disease burden through side effects. To add quality to life, alternate methods of symptom management need to be identified. Objective: To demonstrate how photobiomodulation, through its numerous mechanisms, may offer an adjunctive therapy in inflammatory bowel disease. Rather than considering only molecular mechanisms, we take an overarching biopsychosocial approach to propose how existing evidence gleaned from other studies may underpin a treatment strategy of potential benefit to people with Crohn’s disease and ulcerative colitis. Main findings: In this paper, the authors have proposed the perspective that photobiomodulation, through an integrated effect on the neuroimmune and microbiome–gut–brain axis, has the potential to be effective in managing the fatigue, pain, and depressive symptoms of people with inflammatory bowel disease. |
| first_indexed | 2024-03-11T03:54:26Z |
| format | Article |
| id | doaj.art-1a280bafad864054b3c9c615eed91510 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T03:54:26Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-1a280bafad864054b3c9c615eed915102023-11-18T00:38:02ZengMDPI AGBiomedicines2227-90592023-05-01115149710.3390/biomedicines11051497A Holistic Perspective on How Photobiomodulation May Influence Fatigue, Pain, and Depression in Inflammatory Bowel Disease: Beyond Molecular MechanismsE-Liisa Laakso0Tatjana Ewais1Mater Research Institute-University of Queensland, South Brisbane, QLD 4101, AustraliaMater Adolescent and Young Adult Health Clinic, South Brisbane, QLD 4101, AustraliaBackground: Numerous mechanisms, mostly molecular, have been tested and proposed for photobiomodulation. Photobiomodulation is finding a niche in the treatment of conditions that have no gold-standard treatment or only partially effective pharmacological treatment. Many chronic conditions are characterised by symptoms for which there is no cure or control and for which pharmaceuticals may add to the disease burden through side effects. To add quality to life, alternate methods of symptom management need to be identified. Objective: To demonstrate how photobiomodulation, through its numerous mechanisms, may offer an adjunctive therapy in inflammatory bowel disease. Rather than considering only molecular mechanisms, we take an overarching biopsychosocial approach to propose how existing evidence gleaned from other studies may underpin a treatment strategy of potential benefit to people with Crohn’s disease and ulcerative colitis. Main findings: In this paper, the authors have proposed the perspective that photobiomodulation, through an integrated effect on the neuroimmune and microbiome–gut–brain axis, has the potential to be effective in managing the fatigue, pain, and depressive symptoms of people with inflammatory bowel disease.https://www.mdpi.com/2227-9059/11/5/1497Crohn’s diseaseulcerative colitisintegrated mechanism |
| spellingShingle | E-Liisa Laakso Tatjana Ewais A Holistic Perspective on How Photobiomodulation May Influence Fatigue, Pain, and Depression in Inflammatory Bowel Disease: Beyond Molecular Mechanisms Biomedicines Crohn’s disease ulcerative colitis integrated mechanism |
| title | A Holistic Perspective on How Photobiomodulation May Influence Fatigue, Pain, and Depression in Inflammatory Bowel Disease: Beyond Molecular Mechanisms |
| title_full | A Holistic Perspective on How Photobiomodulation May Influence Fatigue, Pain, and Depression in Inflammatory Bowel Disease: Beyond Molecular Mechanisms |
| title_fullStr | A Holistic Perspective on How Photobiomodulation May Influence Fatigue, Pain, and Depression in Inflammatory Bowel Disease: Beyond Molecular Mechanisms |
| title_full_unstemmed | A Holistic Perspective on How Photobiomodulation May Influence Fatigue, Pain, and Depression in Inflammatory Bowel Disease: Beyond Molecular Mechanisms |
| title_short | A Holistic Perspective on How Photobiomodulation May Influence Fatigue, Pain, and Depression in Inflammatory Bowel Disease: Beyond Molecular Mechanisms |
| title_sort | holistic perspective on how photobiomodulation may influence fatigue pain and depression in inflammatory bowel disease beyond molecular mechanisms |
| topic | Crohn’s disease ulcerative colitis integrated mechanism |
| url | https://www.mdpi.com/2227-9059/11/5/1497 |
| work_keys_str_mv | AT eliisalaakso aholisticperspectiveonhowphotobiomodulationmayinfluencefatiguepainanddepressionininflammatoryboweldiseasebeyondmolecularmechanisms AT tatjanaewais aholisticperspectiveonhowphotobiomodulationmayinfluencefatiguepainanddepressionininflammatoryboweldiseasebeyondmolecularmechanisms AT eliisalaakso holisticperspectiveonhowphotobiomodulationmayinfluencefatiguepainanddepressionininflammatoryboweldiseasebeyondmolecularmechanisms AT tatjanaewais holisticperspectiveonhowphotobiomodulationmayinfluencefatiguepainanddepressionininflammatoryboweldiseasebeyondmolecularmechanisms |