UDP/P2Y6 receptor signaling regulates IgE-dependent degranulation in human basophils

UDP/P2Y6 receptor signaling regulates IgE-dependent degranulation in human basophils

Background: P2Y purinergic receptors (P2YR) are G protein-coupled receptors that are stimulated by extracellular nucleotides. They mediate cellular effects by regulating cAMP production, protein kinase C activation, inositol trisphosphate generation, and Ca2+ release from intracellular stores. The P...

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Bibliographic Details
Main Authors: Manabu Nakano, Koichi Ito, Takeo Yuno, Nobuyuki Soma, Syun Aburakawa, Kosuke Kasai, Toshiya Nakamura, Hideki Takami
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Allergology International
Subjects:
Basophil
IgE-dependent degranulation
MRS2578
P2Y6
UDP
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893017300187

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