Monitoring the quality of domestic measles prevention vaccines
Relevance. The need to increase vaccination coverage in order to eliminate measles in Russia and increase public confidence in vaccination requires constant monitoring of the quality of vaccines used for measles prevention. Aim. Analysis of laboratory quality parameters of commercial series of vacci...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2021-05-01
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| Series: | Эпидемиология и вакцинопрофилактика |
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| Online Access: | https://www.epidemvac.ru/jour/article/view/1226 |
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| author | A. S. Binyatova T. n. Yunasova K. A. Sarkisyan D. S. Davydov T. N. Ilyasova A. A. Movsesyants |
| author_facet | A. S. Binyatova T. n. Yunasova K. A. Sarkisyan D. S. Davydov T. N. Ilyasova A. A. Movsesyants |
| author_sort | A. S. Binyatova |
| collection | DOAJ |
| description | Relevance. The need to increase vaccination coverage in order to eliminate measles in Russia and increase public confidence in vaccination requires constant monitoring of the quality of vaccines used for measles prevention. Aim. Analysis of laboratory quality parameters of commercial series of vaccines for measles prevention produced by JSC NPO Microgen, issued from 2015 to 2020, in comparison with the series issued in the period from 2002 to 2009. Materials and methods. The object of the study was a live measles culture vaccine and a live mumps-measles culture vaccine produced by JSC «NPO «Microgen». The quality analysis of vaccines was carried out according to the consolidated production and control protocols of 422 series of measles vaccine and 855 series of mumps-measles vaccine issued in 2015-2020, and 1043 series of measles vaccine and 902 series of mumpsmeasles vaccine issued in 2002-2009. Results and discussion. It is shown that the quality of the studied vaccines is stable during 16 years of monitoring. The sensitizing properties of both vaccines significantly decreased during the last 6 years of follow-up due to a decrease in the residual content of the antibiotic in the vaccination dose to less than the detection limit, as well as due to the low content of heterogeneous protein (bovine serum albumin). Conclusion. The quality of domestic vaccines for the prevention of measles and mumps meets who requirements; it is characterized by stability over 16 years of follow-up and minimal sensitizing properties. Information about the quality of domestic vaccines for the prevention of measles is an important argument for countering the antivaccination movement, which is a global problem and is recognized by who as one of the most important threats to the health of the world's population. |
| first_indexed | 2024-04-10T02:49:36Z |
| format | Article |
| id | doaj.art-1a29402d62994b428a167fb0a540b45e |
| institution | Directory Open Access Journal |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| last_indexed | 2025-03-14T11:06:39Z |
| publishDate | 2021-05-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj.art-1a29402d62994b428a167fb0a540b45e2025-03-02T10:40:33ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942021-05-01202586710.31631/2073-3046-2021-20-2-58-67735Monitoring the quality of domestic measles prevention vaccinesA. S. Binyatova0T. n. Yunasova1K. A. Sarkisyan2D. S. Davydov3T. N. Ilyasova4A. A. Movsesyants5Scientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsScientific Centre for Expert Evaluation of Medicinal ProductsRelevance. The need to increase vaccination coverage in order to eliminate measles in Russia and increase public confidence in vaccination requires constant monitoring of the quality of vaccines used for measles prevention. Aim. Analysis of laboratory quality parameters of commercial series of vaccines for measles prevention produced by JSC NPO Microgen, issued from 2015 to 2020, in comparison with the series issued in the period from 2002 to 2009. Materials and methods. The object of the study was a live measles culture vaccine and a live mumps-measles culture vaccine produced by JSC «NPO «Microgen». The quality analysis of vaccines was carried out according to the consolidated production and control protocols of 422 series of measles vaccine and 855 series of mumps-measles vaccine issued in 2015-2020, and 1043 series of measles vaccine and 902 series of mumpsmeasles vaccine issued in 2002-2009. Results and discussion. It is shown that the quality of the studied vaccines is stable during 16 years of monitoring. The sensitizing properties of both vaccines significantly decreased during the last 6 years of follow-up due to a decrease in the residual content of the antibiotic in the vaccination dose to less than the detection limit, as well as due to the low content of heterogeneous protein (bovine serum albumin). Conclusion. The quality of domestic vaccines for the prevention of measles and mumps meets who requirements; it is characterized by stability over 16 years of follow-up and minimal sensitizing properties. Information about the quality of domestic vaccines for the prevention of measles is an important argument for countering the antivaccination movement, which is a global problem and is recognized by who as one of the most important threats to the health of the world's population.https://www.epidemvac.ru/jour/article/view/1226мeasles vaccinemumps-measles vaccinequality indicatorsvaccination effectivenessquality stabilityconfidence in vaccinationcontrol cards |
| spellingShingle | A. S. Binyatova T. n. Yunasova K. A. Sarkisyan D. S. Davydov T. N. Ilyasova A. A. Movsesyants Monitoring the quality of domestic measles prevention vaccines Эпидемиология и вакцинопрофилактика мeasles vaccine mumps-measles vaccine quality indicators vaccination effectiveness quality stability confidence in vaccination control cards |
| title | Monitoring the quality of domestic measles prevention vaccines |
| title_full | Monitoring the quality of domestic measles prevention vaccines |
| title_fullStr | Monitoring the quality of domestic measles prevention vaccines |
| title_full_unstemmed | Monitoring the quality of domestic measles prevention vaccines |
| title_short | Monitoring the quality of domestic measles prevention vaccines |
| title_sort | monitoring the quality of domestic measles prevention vaccines |
| topic | мeasles vaccine mumps-measles vaccine quality indicators vaccination effectiveness quality stability confidence in vaccination control cards |
| url | https://www.epidemvac.ru/jour/article/view/1226 |
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