Study of the association between 3111T/C polymorphism of the CLOCK gene and the presence of overweight in schoolchildren,
Objectives: To evaluate the association between 3111T/C polymorphism of the CLOCK gene and the presence of obesity and sleep duration in children aged 6-13 years. In adults, this genetic variant has been associated with duration of sleep, ghrelin levels, weight, and eating habits. Although short sle...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-09-01
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| Series: | Jornal de Pediatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000500500&lng=en&tlng=en |
| _version_ | 1811253290842718208 |
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| author | Nayara P. Giovaninni Jeanne T. Fuly Leonardo I. Moraes Thais N. Coutinho Ericka B. Trarbach Alexander A. de L. Jorge Everlayny F. Costalonga |
| author_facet | Nayara P. Giovaninni Jeanne T. Fuly Leonardo I. Moraes Thais N. Coutinho Ericka B. Trarbach Alexander A. de L. Jorge Everlayny F. Costalonga |
| author_sort | Nayara P. Giovaninni |
| collection | DOAJ |
| description | Objectives: To evaluate the association between 3111T/C polymorphism of the CLOCK gene and the presence of obesity and sleep duration in children aged 6-13 years. In adults, this genetic variant has been associated with duration of sleep, ghrelin levels, weight, and eating habits. Although short sleep duration has been linked to obesity in children, no study has aimed to identify the possible molecular mechanisms of this association to date. Methods: Weight, height, and circumferences were transformed into Z-scores for age and gender. Genotyping was performed using TaqMan methodology. A questionnaire regarding hours of sleep was provided to parents. The appropriate statistical tests were performed. Results: This study evaluated 370 children (45% males, 55% females, mean age 8.5 ± 1.5 years). The prevalence of overweight was 18%. The duration of sleep was, on average, 9.7 hours, and was inversely related to age (p < 0.001). Genotype distribution was: 4% CC, 31% CT, and 65% TT. There was a trend toward higher prevalence of overweight in children who slept less than nine hours (23%) when compared to those who slept more than ten hours (16%, p = 0.06). Genotype was not significantly correlated to any of the assessed outcomes. Conclusions: The CLOCK 3111T/C polymorphism was not significantly associated with overweight or sleep duration in children in this city. |
| first_indexed | 2024-04-12T16:48:39Z |
| format | Article |
| id | doaj.art-1a2a254e79f24191942f6558eb451a37 |
| institution | Directory Open Access Journal |
| issn | 1678-4782 |
| language | English |
| last_indexed | 2024-04-12T16:48:39Z |
| publishDate | 2014-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Jornal de Pediatria |
| spelling | doaj.art-1a2a254e79f24191942f6558eb451a372022-12-22T03:24:28ZengElsevierJornal de Pediatria1678-47822014-09-0190550050510.1016/j.jped.2014.01.011S0021-75572014000500500Study of the association between 3111T/C polymorphism of the CLOCK gene and the presence of overweight in schoolchildren,Nayara P. GiovaninniJeanne T. FulyLeonardo I. MoraesThais N. CoutinhoEricka B. TrarbachAlexander A. de L. JorgeEverlayny F. CostalongaObjectives: To evaluate the association between 3111T/C polymorphism of the CLOCK gene and the presence of obesity and sleep duration in children aged 6-13 years. In adults, this genetic variant has been associated with duration of sleep, ghrelin levels, weight, and eating habits. Although short sleep duration has been linked to obesity in children, no study has aimed to identify the possible molecular mechanisms of this association to date. Methods: Weight, height, and circumferences were transformed into Z-scores for age and gender. Genotyping was performed using TaqMan methodology. A questionnaire regarding hours of sleep was provided to parents. The appropriate statistical tests were performed. Results: This study evaluated 370 children (45% males, 55% females, mean age 8.5 ± 1.5 years). The prevalence of overweight was 18%. The duration of sleep was, on average, 9.7 hours, and was inversely related to age (p < 0.001). Genotype distribution was: 4% CC, 31% CT, and 65% TT. There was a trend toward higher prevalence of overweight in children who slept less than nine hours (23%) when compared to those who slept more than ten hours (16%, p = 0.06). Genotype was not significantly correlated to any of the assessed outcomes. Conclusions: The CLOCK 3111T/C polymorphism was not significantly associated with overweight or sleep duration in children in this city.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000500500&lng=en&tlng=enObesidade infantilDuração do sonoCLOCKPolimorfismo |
| spellingShingle | Nayara P. Giovaninni Jeanne T. Fuly Leonardo I. Moraes Thais N. Coutinho Ericka B. Trarbach Alexander A. de L. Jorge Everlayny F. Costalonga Study of the association between 3111T/C polymorphism of the CLOCK gene and the presence of overweight in schoolchildren, Jornal de Pediatria Obesidade infantil Duração do sono CLOCK Polimorfismo |
| title | Study of the association between 3111T/C polymorphism of the CLOCK gene and the presence of overweight in schoolchildren, |
| title_full | Study of the association between 3111T/C polymorphism of the CLOCK gene and the presence of overweight in schoolchildren, |
| title_fullStr | Study of the association between 3111T/C polymorphism of the CLOCK gene and the presence of overweight in schoolchildren, |
| title_full_unstemmed | Study of the association between 3111T/C polymorphism of the CLOCK gene and the presence of overweight in schoolchildren, |
| title_short | Study of the association between 3111T/C polymorphism of the CLOCK gene and the presence of overweight in schoolchildren, |
| title_sort | study of the association between 3111t c polymorphism of the clock gene and the presence of overweight in schoolchildren |
| topic | Obesidade infantil Duração do sono CLOCK Polimorfismo |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572014000500500&lng=en&tlng=en |
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