Antibacterial and Anti-Fungal Biological Activities for Acrylonitrile, Acrylamide and 2-Acrylamido-2-Methylpropane Sulphonic Acid Crosslinked Terpolymers
There is a pressing demand to synthesize polymers that have antibacterial and antifungal properties. The aim of this study was to synthesize a crosslinked hydrophilic terpolymer with acrylamide, acrylonitrile, acrylic acid, acrylamido-2-methylpropane sulphonic acid and ethylene glycol dimethacrylate...
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2020-10-01
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| Series: | Materials |
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| Online Access: | https://www.mdpi.com/1996-1944/13/21/4891 |
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| author | Reem K. Farag Ayman M. Atta Ahmed Labena Salma H. AlHawari Gehan Safwat Ayman Diab |
| author_facet | Reem K. Farag Ayman M. Atta Ahmed Labena Salma H. AlHawari Gehan Safwat Ayman Diab |
| author_sort | Reem K. Farag |
| collection | DOAJ |
| description | There is a pressing demand to synthesize polymers that have antibacterial and antifungal properties. The aim of this study was to synthesize a crosslinked hydrophilic terpolymer with acrylamide, acrylonitrile, acrylic acid, acrylamido-2-methylpropane sulphonic acid and ethylene glycol dimethacrylate as a crosslinker. The chemical structure and thermal stability of the prepared cross-linked terpolymers were confirmed by spectroscopic and thermal analyses. Moreover, the swelling experiments were performed to investigate their swelling capacity. Furthermore, the efficiency of the synthesized cross-linked polymer gels was assessed as an antimicrobial agent against Gram-positive, Gram-negative bacteria and fungal strains. The synthesized polymers showed broad inhibition effect, with more antibacterial activity by the AM4 polymer sample containing high percentage of acrylonitrile monomer in the prepared terpolymers (4 mol ratio of acrylic acid: 1 mol ratio of acrylamide: 16 mole ratio of acrylonitrile against Gram negative bacterial strain), while sample M3 terpolymer (1 mol ratio of acrylamide: 1 mole ratio acrylonitrile: 3 mole ratio of acrylamido-2-methylpropane sulphonic acid) showed a promising anti-fungal activity. |
| first_indexed | 2024-03-10T15:11:37Z |
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| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-10T15:11:37Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-1a2b7a7ffe884aaa972c30e90a0e5c962023-11-20T19:18:08ZengMDPI AGMaterials1996-19442020-10-011321489110.3390/ma13214891Antibacterial and Anti-Fungal Biological Activities for Acrylonitrile, Acrylamide and 2-Acrylamido-2-Methylpropane Sulphonic Acid Crosslinked TerpolymersReem K. Farag0Ayman M. Atta1Ahmed Labena2Salma H. AlHawari3Gehan Safwat4Ayman Diab5Department of Application, Egyptian Petroleum Research Institute (EPRI), Nasr City, Cairo 11727, EgyptChemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartment of Application, Egyptian Petroleum Research Institute (EPRI), Nasr City, Cairo 11727, EgyptFaculty of Biotechnology, October University for Modern Science and Arts, 26 July Mehwar Road Intersection with Wahat Road, 6th October City 11435, EgyptFaculty of Biotechnology, October University for Modern Science and Arts, 26 July Mehwar Road Intersection with Wahat Road, 6th October City 11435, EgyptFaculty of Biotechnology, October University for Modern Science and Arts, 26 July Mehwar Road Intersection with Wahat Road, 6th October City 11435, EgyptThere is a pressing demand to synthesize polymers that have antibacterial and antifungal properties. The aim of this study was to synthesize a crosslinked hydrophilic terpolymer with acrylamide, acrylonitrile, acrylic acid, acrylamido-2-methylpropane sulphonic acid and ethylene glycol dimethacrylate as a crosslinker. The chemical structure and thermal stability of the prepared cross-linked terpolymers were confirmed by spectroscopic and thermal analyses. Moreover, the swelling experiments were performed to investigate their swelling capacity. Furthermore, the efficiency of the synthesized cross-linked polymer gels was assessed as an antimicrobial agent against Gram-positive, Gram-negative bacteria and fungal strains. The synthesized polymers showed broad inhibition effect, with more antibacterial activity by the AM4 polymer sample containing high percentage of acrylonitrile monomer in the prepared terpolymers (4 mol ratio of acrylic acid: 1 mol ratio of acrylamide: 16 mole ratio of acrylonitrile against Gram negative bacterial strain), while sample M3 terpolymer (1 mol ratio of acrylamide: 1 mole ratio acrylonitrile: 3 mole ratio of acrylamido-2-methylpropane sulphonic acid) showed a promising anti-fungal activity.https://www.mdpi.com/1996-1944/13/21/4891polymergel terpolymercross-linked polymeranti-bacterialanti-fungal |
| spellingShingle | Reem K. Farag Ayman M. Atta Ahmed Labena Salma H. AlHawari Gehan Safwat Ayman Diab Antibacterial and Anti-Fungal Biological Activities for Acrylonitrile, Acrylamide and 2-Acrylamido-2-Methylpropane Sulphonic Acid Crosslinked Terpolymers Materials polymer gel terpolymer cross-linked polymer anti-bacterial anti-fungal |
| title | Antibacterial and Anti-Fungal Biological Activities for Acrylonitrile, Acrylamide and 2-Acrylamido-2-Methylpropane Sulphonic Acid Crosslinked Terpolymers |
| title_full | Antibacterial and Anti-Fungal Biological Activities for Acrylonitrile, Acrylamide and 2-Acrylamido-2-Methylpropane Sulphonic Acid Crosslinked Terpolymers |
| title_fullStr | Antibacterial and Anti-Fungal Biological Activities for Acrylonitrile, Acrylamide and 2-Acrylamido-2-Methylpropane Sulphonic Acid Crosslinked Terpolymers |
| title_full_unstemmed | Antibacterial and Anti-Fungal Biological Activities for Acrylonitrile, Acrylamide and 2-Acrylamido-2-Methylpropane Sulphonic Acid Crosslinked Terpolymers |
| title_short | Antibacterial and Anti-Fungal Biological Activities for Acrylonitrile, Acrylamide and 2-Acrylamido-2-Methylpropane Sulphonic Acid Crosslinked Terpolymers |
| title_sort | antibacterial and anti fungal biological activities for acrylonitrile acrylamide and 2 acrylamido 2 methylpropane sulphonic acid crosslinked terpolymers |
| topic | polymer gel terpolymer cross-linked polymer anti-bacterial anti-fungal |
| url | https://www.mdpi.com/1996-1944/13/21/4891 |
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