Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and their association with the severity of depression and as biomarkers for suicidal behaviour among patients diagnosed with depression
Background: Depression has a significant impact on a person's quality of life and is a leading cause of death by suicide. Growing evidence points to a function for the immune and inflammatory systems in the pathophysiology of depression. Studies have shown that Neutrophil-to-Lymphocyte Ratio (N...
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Krishna Vishwa Vidyapeeth (Deemed to be University), Karad
2023-10-01
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| Series: | Journal of Krishna Institute of Medical Sciences University |
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| Online Access: | https://jkimsu.com/jkimsu-vol12no4/JKIMSU,%20Vol.%2012,%20No.%204,%20October-December%202023%20Page%2051-57.pdf |
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| author | Swathi Niranjan Hebbar YR Soumya G Hegde Tintu Mathew |
| author_facet | Swathi Niranjan Hebbar YR Soumya G Hegde Tintu Mathew |
| author_sort | Swathi |
| collection | DOAJ |
| description | Background: Depression has a significant impact on a person's quality of life and is a leading cause of death by suicide. Growing evidence points to a function for the immune and inflammatory systems in the pathophysiology of depression. Studies have shown that Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) are positively associated with depression severity and may be peripheral biomarkers of suicidal behaviour in depressed patients. Aim and Objectives: To find out NLR, and PLR values in patients with depression and their association with the severity of depression and to test their validity as biomarkers for suicidality. Material and Methods: Our study population consisted of 150 patients with diagnosed depressive disorder. Patients were evaluated
with the Hamilton Depression Rating Scale (HAM-D). Patients were classified into 3 groups according to their HAM-D score such as mild, moderate and severe depression. NLR and PLR values were estimated. Results: Patients with higher HAM-D score had significantly higher NLR and PLR levels compared to patients with lower HAM-D score. NLR and PLR values were substantially higher for the suicide attempters group than the non-suicide attempters. The optimal cut off value for NLR in predicting the risk for suicide attempt was 1.96 with sensitivity of 75%, and specificity of 74%. Conclusion: Our data suggest that NLR and PLR values may be considered as easily accessible and cost-effective strategies to determine suicide risk in depression. |
| first_indexed | 2024-04-24T20:10:38Z |
| format | Article |
| id | doaj.art-1a2c29a4a95f4c6fb8217bf14c642b58 |
| institution | Directory Open Access Journal |
| issn | 2231-4261 |
| language | English |
| last_indexed | 2025-03-20T03:36:11Z |
| publishDate | 2023-10-01 |
| publisher | Krishna Vishwa Vidyapeeth (Deemed to be University), Karad |
| record_format | Article |
| series | Journal of Krishna Institute of Medical Sciences University |
| spelling | doaj.art-1a2c29a4a95f4c6fb8217bf14c642b582024-10-03T06:49:23ZengKrishna Vishwa Vidyapeeth (Deemed to be University), KaradJournal of Krishna Institute of Medical Sciences University2231-42612023-10-011245157 Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and their association with the severity of depression and as biomarkers for suicidal behaviour among patients diagnosed with depression Swathi0Niranjan Hebbar YR1Soumya G Hegde2Tintu Mathew3Department of Psychiatry, Subbaiah Institute of Medical Sciences, Shivamogga -577202 (Karnataka) IndiaDepartment of Psychiatry, Chamarajanagar Institute of Medical Sciences, Chamarajanagara-571313 (Karnataka), IndiaDepartment of Dermatology, Chamarajanagar Institute of Medical Sciences, Chamarajanagara-571313 (Karnataka), IndiaDepartment of Psychiatry, Subbaiah Institute of Medical Sciences, Shivamogga -577202 (Karnataka) IndiaBackground: Depression has a significant impact on a person's quality of life and is a leading cause of death by suicide. Growing evidence points to a function for the immune and inflammatory systems in the pathophysiology of depression. Studies have shown that Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) are positively associated with depression severity and may be peripheral biomarkers of suicidal behaviour in depressed patients. Aim and Objectives: To find out NLR, and PLR values in patients with depression and their association with the severity of depression and to test their validity as biomarkers for suicidality. Material and Methods: Our study population consisted of 150 patients with diagnosed depressive disorder. Patients were evaluated with the Hamilton Depression Rating Scale (HAM-D). Patients were classified into 3 groups according to their HAM-D score such as mild, moderate and severe depression. NLR and PLR values were estimated. Results: Patients with higher HAM-D score had significantly higher NLR and PLR levels compared to patients with lower HAM-D score. NLR and PLR values were substantially higher for the suicide attempters group than the non-suicide attempters. The optimal cut off value for NLR in predicting the risk for suicide attempt was 1.96 with sensitivity of 75%, and specificity of 74%. Conclusion: Our data suggest that NLR and PLR values may be considered as easily accessible and cost-effective strategies to determine suicide risk in depression.https://jkimsu.com/jkimsu-vol12no4/JKIMSU,%20Vol.%2012,%20No.%204,%20October-December%202023%20Page%2051-57.pdfdepressionneutrophil -to-lymphocyte ratioplatelet -to- lymphocyte ratio |
| spellingShingle | Swathi Niranjan Hebbar YR Soumya G Hegde Tintu Mathew Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and their association with the severity of depression and as biomarkers for suicidal behaviour among patients diagnosed with depression Journal of Krishna Institute of Medical Sciences University depression neutrophil -to-lymphocyte ratio platelet -to- lymphocyte ratio |
| title | Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and their association with the severity of depression and as biomarkers for suicidal behaviour among patients diagnosed with depression |
| title_full | Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and their association with the severity of depression and as biomarkers for suicidal behaviour among patients diagnosed with depression |
| title_fullStr | Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and their association with the severity of depression and as biomarkers for suicidal behaviour among patients diagnosed with depression |
| title_full_unstemmed | Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and their association with the severity of depression and as biomarkers for suicidal behaviour among patients diagnosed with depression |
| title_short | Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and their association with the severity of depression and as biomarkers for suicidal behaviour among patients diagnosed with depression |
| title_sort | neutrophil to lymphocyte ratio platelet to lymphocyte ratio and their association with the severity of depression and as biomarkers for suicidal behaviour among patients diagnosed with depression |
| topic | depression neutrophil -to-lymphocyte ratio platelet -to- lymphocyte ratio |
| url | https://jkimsu.com/jkimsu-vol12no4/JKIMSU,%20Vol.%2012,%20No.%204,%20October-December%202023%20Page%2051-57.pdf |
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