E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy.

E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy.

The protein optineurin coded by OPTN gene is involved in several functions including regulation of endocytic trafficking, autophagy and signal transduction. Certain missense mutations in the gene OPTN cause normal tension glaucoma. A glaucoma-causing mutant of optineurin, E50K, induces death selecti...

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Bibliografski detalji
Glavni autori: Madhavi Latha Somaraju Chalasani, Asha Kumari, Vegesna Radha, Ghanshyam Swarup
Format: Članak
Jezik:English
Izdano: Public Library of Science (PLoS) 2014-01-01
Serija:PLoS ONE
Online pristup:http://europepmc.org/articles/PMC3994150?pdf=render

Internet

http://europepmc.org/articles/PMC3994150?pdf=render

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