Serum creatinine/cystatin C ratio as a prognostic indicator for patients with colorectal cancer
BackgroundThis study aimed to explore the relationship between creatinine/cystatin C ratio and progression-free survival (PFS) and overall survival (OS) in colorectal cancer (CRC) patients undergoing surgical treatment.MethodsA retrospective analysis was conducted on 975 CRC patients who underwent s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1155520/full |
| _version_ | 1797799472591273984 |
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| author | Shunhui Gao Shunhui Gao Hailun Xie Hailun Xie Lishuang Wei Mingxiang Liu Mingxiang Liu Yanren Liang Yanren Liang Qiwen Wang Qiwen Wang Shuangyi Tang Jialiang Gan Jialiang Gan |
| author_facet | Shunhui Gao Shunhui Gao Hailun Xie Hailun Xie Lishuang Wei Mingxiang Liu Mingxiang Liu Yanren Liang Yanren Liang Qiwen Wang Qiwen Wang Shuangyi Tang Jialiang Gan Jialiang Gan |
| author_sort | Shunhui Gao |
| collection | DOAJ |
| description | BackgroundThis study aimed to explore the relationship between creatinine/cystatin C ratio and progression-free survival (PFS) and overall survival (OS) in colorectal cancer (CRC) patients undergoing surgical treatment.MethodsA retrospective analysis was conducted on 975 CRC patients who underwent surgical resection from January 2012 to 2015. Restricted three-sample curve to display the non-linear relationship between PFS/OS and creatinine-cystatin C ratio. Cox regression model and Kaplan-Meier method were used to evaluate the effect of the creatinine-cystatin C ratio on the survival of CRC patients. Prognostic variables with p-value ≤0.05 in multivariate analysis were used to construct prognostic nomograms. The receiver operator characteristic curve was used to compare the efficacy of prognostic nomograms and the traditional pathological stage.ResultsThere was a negative linear relationship between creatinine/cystatin C ratio and adverse PFS in CRC patients. Patients with low creatinine/cystatin C ratio had significantly lower PFS/OS than those with high creatinine/cystatin C ratio (PFS, 50.8% vs. 63.9%, p = 0.002; OS, 52.5% vs. 68.9%, p < 0.001). Multivariate analysis showed that low creatinine/cystatin C ratio was an independent risk factor for PFS (HR=1.286, 95%CI = 1.007–1.642, p=0.044) and OS (HR=1.410, 95%CI=1.087–1.829, p=0.010) of CRC patients. The creatinine/cystatin C ratio-based prognostic nomograms have good predictive performance, with a concordance index above 0.7, which can predict the 1–5-year prognosis.ConclusionCreatinine/cystatin C ratio may be an effective prognostic marker for predicting PFS and OS in CRC patients, aid in pathological staging, and along with tumour markers help in-depth prognostic stratification in CRC patients. |
| first_indexed | 2024-03-13T04:20:25Z |
| format | Article |
| id | doaj.art-1a2e79c36cd8429289426875bb22a97f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T04:20:25Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-1a2e79c36cd8429289426875bb22a97f2023-06-20T10:23:24ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-06-011310.3389/fonc.2023.11555201155520Serum creatinine/cystatin C ratio as a prognostic indicator for patients with colorectal cancerShunhui Gao0Shunhui Gao1Hailun Xie2Hailun Xie3Lishuang Wei4Mingxiang Liu5Mingxiang Liu6Yanren Liang7Yanren Liang8Qiwen Wang9Qiwen Wang10Shuangyi Tang11Jialiang Gan12Jialiang Gan13Department of Gastrointestinal Surgery, The Second People’s Hospital of Nanning, Nanning, ChinaGuangxi Key Laboratory of Enhanced Recovery After Surgery for Gastrointestinal Cancer, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of Enhanced Recovery After Surgery for Gastrointestinal Cancer, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaDepartment of Colorectal and Anal Surgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaDepartment of Geriatric Respiratory Disease Ward, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of Enhanced Recovery After Surgery for Gastrointestinal Cancer, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaDepartment of Colorectal and Anal Surgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of Enhanced Recovery After Surgery for Gastrointestinal Cancer, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaDepartment of Colorectal and Anal Surgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of Enhanced Recovery After Surgery for Gastrointestinal Cancer, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaDepartment of Colorectal and Anal Surgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaDepartment of Pharmacy, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of Enhanced Recovery After Surgery for Gastrointestinal Cancer, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaDepartment of Colorectal and Anal Surgery, The First Affiliated Hospital, Guangxi Medical University, Nanning, ChinaBackgroundThis study aimed to explore the relationship between creatinine/cystatin C ratio and progression-free survival (PFS) and overall survival (OS) in colorectal cancer (CRC) patients undergoing surgical treatment.MethodsA retrospective analysis was conducted on 975 CRC patients who underwent surgical resection from January 2012 to 2015. Restricted three-sample curve to display the non-linear relationship between PFS/OS and creatinine-cystatin C ratio. Cox regression model and Kaplan-Meier method were used to evaluate the effect of the creatinine-cystatin C ratio on the survival of CRC patients. Prognostic variables with p-value ≤0.05 in multivariate analysis were used to construct prognostic nomograms. The receiver operator characteristic curve was used to compare the efficacy of prognostic nomograms and the traditional pathological stage.ResultsThere was a negative linear relationship between creatinine/cystatin C ratio and adverse PFS in CRC patients. Patients with low creatinine/cystatin C ratio had significantly lower PFS/OS than those with high creatinine/cystatin C ratio (PFS, 50.8% vs. 63.9%, p = 0.002; OS, 52.5% vs. 68.9%, p < 0.001). Multivariate analysis showed that low creatinine/cystatin C ratio was an independent risk factor for PFS (HR=1.286, 95%CI = 1.007–1.642, p=0.044) and OS (HR=1.410, 95%CI=1.087–1.829, p=0.010) of CRC patients. The creatinine/cystatin C ratio-based prognostic nomograms have good predictive performance, with a concordance index above 0.7, which can predict the 1–5-year prognosis.ConclusionCreatinine/cystatin C ratio may be an effective prognostic marker for predicting PFS and OS in CRC patients, aid in pathological staging, and along with tumour markers help in-depth prognostic stratification in CRC patients.https://www.frontiersin.org/articles/10.3389/fonc.2023.1155520/fullcreatinine/cystatin C rationutritioncolorectal cancerprogression-free survivaloverall survival |
| spellingShingle | Shunhui Gao Shunhui Gao Hailun Xie Hailun Xie Lishuang Wei Mingxiang Liu Mingxiang Liu Yanren Liang Yanren Liang Qiwen Wang Qiwen Wang Shuangyi Tang Jialiang Gan Jialiang Gan Serum creatinine/cystatin C ratio as a prognostic indicator for patients with colorectal cancer Frontiers in Oncology creatinine/cystatin C ratio nutrition colorectal cancer progression-free survival overall survival |
| title | Serum creatinine/cystatin C ratio as a prognostic indicator for patients with colorectal cancer |
| title_full | Serum creatinine/cystatin C ratio as a prognostic indicator for patients with colorectal cancer |
| title_fullStr | Serum creatinine/cystatin C ratio as a prognostic indicator for patients with colorectal cancer |
| title_full_unstemmed | Serum creatinine/cystatin C ratio as a prognostic indicator for patients with colorectal cancer |
| title_short | Serum creatinine/cystatin C ratio as a prognostic indicator for patients with colorectal cancer |
| title_sort | serum creatinine cystatin c ratio as a prognostic indicator for patients with colorectal cancer |
| topic | creatinine/cystatin C ratio nutrition colorectal cancer progression-free survival overall survival |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1155520/full |
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