Mortality due to COVID-19 infection: A comparison of first and second waves
Background The USA suffered an initial wave of COVID-19 cases from March to July in 2020. Cases again surged in August 2020 as business restrictions were lifted. We aimed to describe demographic, treatment, and mortality differences between both waves. Methods We identified all hospitalized patients...
| প্রধান লেখক: | , , , , , |
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| বিন্যাস: | প্রবন্ধ |
| ভাষা: | English |
| প্রকাশিত: |
Greater Baltimore Medical Center
2021-11-01
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| মালা: | Journal of Community Hospital Internal Medicine Perspectives |
| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | http://dx.doi.org/10.1080/20009666.2021.1978154 |
| _version_ | 1828079870612078592 |
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| author | Olubunmi Oladunjoye Molly Gallagher Tom Wasser Adeolu Oladunjoye Susmita Paladugu Anthony Donato |
| author_facet | Olubunmi Oladunjoye Molly Gallagher Tom Wasser Adeolu Oladunjoye Susmita Paladugu Anthony Donato |
| author_sort | Olubunmi Oladunjoye |
| collection | DOAJ |
| description | Background The USA suffered an initial wave of COVID-19 cases from March to July in 2020. Cases again surged in August 2020 as business restrictions were lifted. We aimed to describe demographic, treatment, and mortality differences between both waves. Methods We identified all hospitalized patients with COVID-19 infection in one US six-hospital health system between 1 March 2020 and 31 January 2021. We compared data obtained on patient demographics, treatment received, and mortality between first and second waves of the pandemic. Results A total of 4434 hospitalized COVID patients were identified, including 1313 patients in the first wave and 3121 patients in the second wave. Mortality was significantly higher in the first wave as compared to the second wave (23.2% vs. 12.3%, p < 0.001). Age and sex were similar in each wave. In the first wave, there were significantly more Non-Hispanic Black patients (28.8 vs. 18.1%, p < 0.001) and Hispanic patients (26.6% vs. 14.9%, p < 0.001) as compared to the second wave. There was a higher mortality rate in the first wave as compared to the second, which persisted after multivariable adjustment for sex, age, ethnicity, laboratory results at admission, treatment received, high flow use and mechanical ventilation (OR: 2.66, 95% CI: 1.83–3.87, p < 0.001). Conclusion Mortality in the second wave was lower than the first wave with significantly higher utilization of steroids, remdesivir and convalescent plasma in second wave. |
| first_indexed | 2024-04-11T03:09:07Z |
| format | Article |
| id | doaj.art-1a2f10b6869b46d2934f20c901b54192 |
| institution | Directory Open Access Journal |
| issn | 2000-9666 |
| language | English |
| last_indexed | 2024-04-11T03:09:07Z |
| publishDate | 2021-11-01 |
| publisher | Greater Baltimore Medical Center |
| record_format | Article |
| series | Journal of Community Hospital Internal Medicine Perspectives |
| spelling | doaj.art-1a2f10b6869b46d2934f20c901b541922023-01-02T12:01:42ZengGreater Baltimore Medical CenterJournal of Community Hospital Internal Medicine Perspectives2000-96662021-11-0111674775210.1080/20009666.2021.19781541978154Mortality due to COVID-19 infection: A comparison of first and second wavesOlubunmi Oladunjoye0Molly Gallagher1Tom Wasser2Adeolu Oladunjoye3Susmita Paladugu4Anthony Donato5Tower Health System, ReadingDrexel University College of MedicineSenior Scientist, Consult-StatBoston Children’s HospitalTower Health System, ReadingTower Health System, ReadingBackground The USA suffered an initial wave of COVID-19 cases from March to July in 2020. Cases again surged in August 2020 as business restrictions were lifted. We aimed to describe demographic, treatment, and mortality differences between both waves. Methods We identified all hospitalized patients with COVID-19 infection in one US six-hospital health system between 1 March 2020 and 31 January 2021. We compared data obtained on patient demographics, treatment received, and mortality between first and second waves of the pandemic. Results A total of 4434 hospitalized COVID patients were identified, including 1313 patients in the first wave and 3121 patients in the second wave. Mortality was significantly higher in the first wave as compared to the second wave (23.2% vs. 12.3%, p < 0.001). Age and sex were similar in each wave. In the first wave, there were significantly more Non-Hispanic Black patients (28.8 vs. 18.1%, p < 0.001) and Hispanic patients (26.6% vs. 14.9%, p < 0.001) as compared to the second wave. There was a higher mortality rate in the first wave as compared to the second, which persisted after multivariable adjustment for sex, age, ethnicity, laboratory results at admission, treatment received, high flow use and mechanical ventilation (OR: 2.66, 95% CI: 1.83–3.87, p < 0.001). Conclusion Mortality in the second wave was lower than the first wave with significantly higher utilization of steroids, remdesivir and convalescent plasma in second wave.http://dx.doi.org/10.1080/20009666.2021.1978154covid-19mortalityhospitalizationpandemic; sars-cov-2 |
| spellingShingle | Olubunmi Oladunjoye Molly Gallagher Tom Wasser Adeolu Oladunjoye Susmita Paladugu Anthony Donato Mortality due to COVID-19 infection: A comparison of first and second waves Journal of Community Hospital Internal Medicine Perspectives covid-19 mortality hospitalization pandemic; sars-cov-2 |
| title | Mortality due to COVID-19 infection: A comparison of first and second waves |
| title_full | Mortality due to COVID-19 infection: A comparison of first and second waves |
| title_fullStr | Mortality due to COVID-19 infection: A comparison of first and second waves |
| title_full_unstemmed | Mortality due to COVID-19 infection: A comparison of first and second waves |
| title_short | Mortality due to COVID-19 infection: A comparison of first and second waves |
| title_sort | mortality due to covid 19 infection a comparison of first and second waves |
| topic | covid-19 mortality hospitalization pandemic; sars-cov-2 |
| url | http://dx.doi.org/10.1080/20009666.2021.1978154 |
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