Enhancing Neuroplasticity in the Chronic Phase After Stroke: Effects of a Soft Robotic Exosuit on Training Intensity and Brain-Derived Neurotrophic Factor
<italic>Objective:</italic> High intensity training may enhance neuroplasticity after stroke; however, gait deficits limit the ability to achieve and sustain high walking training intensities. We hypothesize that soft robotic exosuits can facilitate speed-based gait training at higher in...
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| Format: | Article |
| Language: | English |
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IEEE
2023-01-01
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| Series: | IEEE Open Journal of Engineering in Medicine and Biology |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/10244088/ |
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| author | Anna V. Roto Cataldo Ashley N. Collimore Johanna Spangler Lillian Ribeirinha-Braga Karen Hutchinson Qing Mei Wang LaDora Thompson Louis N. Awad |
| author_facet | Anna V. Roto Cataldo Ashley N. Collimore Johanna Spangler Lillian Ribeirinha-Braga Karen Hutchinson Qing Mei Wang LaDora Thompson Louis N. Awad |
| author_sort | Anna V. Roto Cataldo |
| collection | DOAJ |
| description | <italic>Objective:</italic> High intensity training may enhance neuroplasticity after stroke; however, gait deficits limit the ability to achieve and sustain high walking training intensities. We hypothesize that soft robotic exosuits can facilitate speed-based gait training at higher intensities and longer durations, resulting in a corresponding increase in circulating brain-derived neurotrophic factor (BDNF). <italic>Results:</italic> Eleven individuals >6-mo post-stroke completed a two-session, pilot randomized crossover trial (NCT05138016). Maximum training speed (Δ: 0.07 ± 0.03 m/s), duration (Δ: 2.07 ± 0.88 min), and intensity (VO<sub>2</sub> peak, Δ: 1.75 ± 0.60 ml-O<sub>2</sub>/kg/min) significantly increased (p < 0.05) during exosuit-augmented training compared to no-exosuit training. Post-session increases in BDNF (Δ: 5.96 ± 2.27 ng/ml, p = 0.03) were observed only after exosuit-augmented training. Biomechanical changes were not observed after exosuit-augmented training; however, a deterioration in gait propulsion symmetry (%Δ: −5 ± 2 %) and an increase in nonparetic propulsion (Δ: 0.9 ± 0.3 %bw) were observed (p < 0.05) after no-exosuit training. <italic>Conclusion:</italic> Soft robotic exosuits facilitate faster, longer duration, and higher intensity walking training associated with enhanced neuroplasticity. |
| first_indexed | 2024-03-08T11:29:44Z |
| format | Article |
| id | doaj.art-1a2f3b19aa1747e7aa400ec6867cab39 |
| institution | Directory Open Access Journal |
| issn | 2644-1276 |
| language | English |
| last_indexed | 2024-03-08T11:29:44Z |
| publishDate | 2023-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Open Journal of Engineering in Medicine and Biology |
| spelling | doaj.art-1a2f3b19aa1747e7aa400ec6867cab392024-01-26T00:02:24ZengIEEEIEEE Open Journal of Engineering in Medicine and Biology2644-12762023-01-01428429110.1109/OJEMB.2023.331339610244088Enhancing Neuroplasticity in the Chronic Phase After Stroke: Effects of a Soft Robotic Exosuit on Training Intensity and Brain-Derived Neurotrophic FactorAnna V. Roto Cataldo0Ashley N. Collimore1https://orcid.org/0000-0001-6002-3667Johanna Spangler2Lillian Ribeirinha-Braga3Karen Hutchinson4Qing Mei Wang5LaDora Thompson6https://orcid.org/0000-0002-6481-9029Louis N. Awad7https://orcid.org/0000-0002-0159-8011Boston University, College of Health and Rehabilitation Sciences: Sargent, Boston, MA, USABoston University, College of Health and Rehabilitation Sciences: Sargent, Boston, MA, USABoston University, College of Health and Rehabilitation Sciences: Sargent, Boston, MA, USABoston University, College of Health and Rehabilitation Sciences: Sargent, Boston, MA, USABoston University, College of Health and Rehabilitation Sciences: Sargent, Boston, MA, USASpaulding Rehabilitation Hospital, Charlestown, MA, USABoston University, College of Health and Rehabilitation Sciences: Sargent, Boston, MA, USABoston University, College of Health and Rehabilitation Sciences: Sargent, Boston, MA, USA<italic>Objective:</italic> High intensity training may enhance neuroplasticity after stroke; however, gait deficits limit the ability to achieve and sustain high walking training intensities. We hypothesize that soft robotic exosuits can facilitate speed-based gait training at higher intensities and longer durations, resulting in a corresponding increase in circulating brain-derived neurotrophic factor (BDNF). <italic>Results:</italic> Eleven individuals >6-mo post-stroke completed a two-session, pilot randomized crossover trial (NCT05138016). Maximum training speed (Δ: 0.07 ± 0.03 m/s), duration (Δ: 2.07 ± 0.88 min), and intensity (VO<sub>2</sub> peak, Δ: 1.75 ± 0.60 ml-O<sub>2</sub>/kg/min) significantly increased (p < 0.05) during exosuit-augmented training compared to no-exosuit training. Post-session increases in BDNF (Δ: 5.96 ± 2.27 ng/ml, p = 0.03) were observed only after exosuit-augmented training. Biomechanical changes were not observed after exosuit-augmented training; however, a deterioration in gait propulsion symmetry (%Δ: −5 ± 2 %) and an increase in nonparetic propulsion (Δ: 0.9 ± 0.3 %bw) were observed (p < 0.05) after no-exosuit training. <italic>Conclusion:</italic> Soft robotic exosuits facilitate faster, longer duration, and higher intensity walking training associated with enhanced neuroplasticity.https://ieeexplore.ieee.org/document/10244088/Brain-derived neurotrophic factorneuroplasticitysoft robotic exosuitstrokewalking |
| spellingShingle | Anna V. Roto Cataldo Ashley N. Collimore Johanna Spangler Lillian Ribeirinha-Braga Karen Hutchinson Qing Mei Wang LaDora Thompson Louis N. Awad Enhancing Neuroplasticity in the Chronic Phase After Stroke: Effects of a Soft Robotic Exosuit on Training Intensity and Brain-Derived Neurotrophic Factor IEEE Open Journal of Engineering in Medicine and Biology Brain-derived neurotrophic factor neuroplasticity soft robotic exosuit stroke walking |
| title | Enhancing Neuroplasticity in the Chronic Phase After Stroke: Effects of a Soft Robotic Exosuit on Training Intensity and Brain-Derived Neurotrophic Factor |
| title_full | Enhancing Neuroplasticity in the Chronic Phase After Stroke: Effects of a Soft Robotic Exosuit on Training Intensity and Brain-Derived Neurotrophic Factor |
| title_fullStr | Enhancing Neuroplasticity in the Chronic Phase After Stroke: Effects of a Soft Robotic Exosuit on Training Intensity and Brain-Derived Neurotrophic Factor |
| title_full_unstemmed | Enhancing Neuroplasticity in the Chronic Phase After Stroke: Effects of a Soft Robotic Exosuit on Training Intensity and Brain-Derived Neurotrophic Factor |
| title_short | Enhancing Neuroplasticity in the Chronic Phase After Stroke: Effects of a Soft Robotic Exosuit on Training Intensity and Brain-Derived Neurotrophic Factor |
| title_sort | enhancing neuroplasticity in the chronic phase after stroke effects of a soft robotic exosuit on training intensity and brain derived neurotrophic factor |
| topic | Brain-derived neurotrophic factor neuroplasticity soft robotic exosuit stroke walking |
| url | https://ieeexplore.ieee.org/document/10244088/ |
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