Low ankle-brachial index and cognitive function after stroke—the PROSpective with Incident Stroke Berlin (PROSCIS-B)
IntroductionLow ankle-brachial index (ABI) ≤0. 9 is a marker for generalized atherosclerosis and a risk factor for cognitive decline in the general population.ObjectiveTo evaluate the impact of ABI ≤0.9 on cognitive function up to 3 years after first-ever ischemic stroke.MethodsData was used from th...
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.963262/full |
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| author | Maria R. V. Stillfried Pia S. Sperber Pia S. Sperber Leonie H. A. Broersen Shufan Huo Shufan Huo Sophie K. Piper Peter U. Heuschmann Matthias Endres Matthias Endres Matthias Endres Matthias Endres Matthias Endres Bob Siegerink Bob Siegerink Thomas G. Liman Thomas G. Liman Thomas G. Liman Thomas G. Liman |
| author_facet | Maria R. V. Stillfried Pia S. Sperber Pia S. Sperber Leonie H. A. Broersen Shufan Huo Shufan Huo Sophie K. Piper Peter U. Heuschmann Matthias Endres Matthias Endres Matthias Endres Matthias Endres Matthias Endres Bob Siegerink Bob Siegerink Thomas G. Liman Thomas G. Liman Thomas G. Liman Thomas G. Liman |
| author_sort | Maria R. V. Stillfried |
| collection | DOAJ |
| description | IntroductionLow ankle-brachial index (ABI) ≤0. 9 is a marker for generalized atherosclerosis and a risk factor for cognitive decline in the general population.ObjectiveTo evaluate the impact of ABI ≤0.9 on cognitive function up to 3 years after first-ever ischemic stroke.MethodsData was used from the “PROspective Cohort with Incident Stroke-Berlin” (PROSCIS-B; NCT01363856). ABI was measured at baseline and categorized into normal (1.4–0.9) vs. low (≤0.9). Cognitive function was assessed with the Montreal Cognitive Assessment (MoCA) and the Mini-Mental-State-Examination (MMSE) at baseline and with the Telephone Interview for Cognitive Status-modified (TICS-m) at 1–3 years of follow-up. We performed confounder adjusted generalized linear models (GLM) to calculate relative risks (RR) for cognitive impairment at baseline (MMSE≤26; MoCA≤25) and linear mixed models (LMM) to estimate the impact of low ABI on TICS-m over time.ResultsWe included 325 patients [mean age: 66 (SD = 13); 38% female, median NIHSS = 2 (IQR = 1–4), ABI≤0.9: 59 (18%)]. Patients with low ABI were at increased risk of cognitive impairment at baseline (adjusted RR for MoCA≤25 = 1.98; 95%-CI:1.24 to 3.16). TICS-m scores were consistently lower over time in patients with low ABI (adjusted ß = −1.96; 95%-CI:−3.55 to −0.37). Independent of ABI, cognitive function did not decline over time (adjusted ß:0.29; 95%-CI:−0.06 to 0.64).ConclusionIn patients with mild to moderate first-ever ischemic stroke, low ABI is associated with reduced cognitive function over a 3-year follow-up.Study Registrationhttps://clinicaltrials.gov; Unique identifier: NCT01363856. |
| first_indexed | 2024-04-12T04:22:00Z |
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| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T04:22:00Z |
| publishDate | 2022-09-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-1a2fa7f4c70940b6a16ece15ddce42f02022-12-22T03:48:11ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-09-011310.3389/fneur.2022.963262963262Low ankle-brachial index and cognitive function after stroke—the PROSpective with Incident Stroke Berlin (PROSCIS-B)Maria R. V. Stillfried0Pia S. Sperber1Pia S. Sperber2Leonie H. A. Broersen3Shufan Huo4Shufan Huo5Sophie K. Piper6Peter U. Heuschmann7Matthias Endres8Matthias Endres9Matthias Endres10Matthias Endres11Matthias Endres12Bob Siegerink13Bob Siegerink14Thomas G. Liman15Thomas G. Liman16Thomas G. Liman17Thomas G. Liman18Center for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, Berlin, GermanyCenter for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, Berlin, GermanyGerman Centre for Cardiovascular Research DZHK, Charité –Universitätsmedizin Berlin, Berlin, GermanyCenter for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, Berlin, GermanyCenter for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, Berlin, GermanyKlinik und Hochschulambulanz für Neurologie, Charité- Universitätsmedizin Berlin, Berlin, GermanyGerman Center for Neurodegenerative Disease DZNE, Berlin Charité-Universitätsmedizin Berlin, Berlin, GermanyInstitute of Biometry and Clinical Epidemiology, University of Würzburg, Würzburg, GermanyCenter for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, Berlin, GermanyGerman Centre for Cardiovascular Research DZHK, Charité –Universitätsmedizin Berlin, Berlin, GermanyKlinik und Hochschulambulanz für Neurologie, Charité- Universitätsmedizin Berlin, Berlin, GermanyGerman Center for Neurodegenerative Disease DZNE, partner site Berlin Charité-Universitätsmedizin Berlin, Berlin, GermanyNeuroCure Clinical Research Center, Charité – Universitätsmedizin Berlin, Berlin, GermanyCenter for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, Berlin, GermanyDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, NetherlandsCenter for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, Berlin, GermanyGerman Centre for Cardiovascular Research DZHK, Charité –Universitätsmedizin Berlin, Berlin, GermanyGerman Center for Neurodegenerative Disease DZNE, partner site Berlin Charité-Universitätsmedizin Berlin, Berlin, GermanyDepartment of Neurology, Carl von Ossietzky University of Oldenburg, Oldenburg, GermanyIntroductionLow ankle-brachial index (ABI) ≤0. 9 is a marker for generalized atherosclerosis and a risk factor for cognitive decline in the general population.ObjectiveTo evaluate the impact of ABI ≤0.9 on cognitive function up to 3 years after first-ever ischemic stroke.MethodsData was used from the “PROspective Cohort with Incident Stroke-Berlin” (PROSCIS-B; NCT01363856). ABI was measured at baseline and categorized into normal (1.4–0.9) vs. low (≤0.9). Cognitive function was assessed with the Montreal Cognitive Assessment (MoCA) and the Mini-Mental-State-Examination (MMSE) at baseline and with the Telephone Interview for Cognitive Status-modified (TICS-m) at 1–3 years of follow-up. We performed confounder adjusted generalized linear models (GLM) to calculate relative risks (RR) for cognitive impairment at baseline (MMSE≤26; MoCA≤25) and linear mixed models (LMM) to estimate the impact of low ABI on TICS-m over time.ResultsWe included 325 patients [mean age: 66 (SD = 13); 38% female, median NIHSS = 2 (IQR = 1–4), ABI≤0.9: 59 (18%)]. Patients with low ABI were at increased risk of cognitive impairment at baseline (adjusted RR for MoCA≤25 = 1.98; 95%-CI:1.24 to 3.16). TICS-m scores were consistently lower over time in patients with low ABI (adjusted ß = −1.96; 95%-CI:−3.55 to −0.37). Independent of ABI, cognitive function did not decline over time (adjusted ß:0.29; 95%-CI:−0.06 to 0.64).ConclusionIn patients with mild to moderate first-ever ischemic stroke, low ABI is associated with reduced cognitive function over a 3-year follow-up.Study Registrationhttps://clinicaltrials.gov; Unique identifier: NCT01363856.https://www.frontiersin.org/articles/10.3389/fneur.2022.963262/fullankle-brachial indexischemic strokeoutcomepost stroke cognitive functionatherosclerosis |
| spellingShingle | Maria R. V. Stillfried Pia S. Sperber Pia S. Sperber Leonie H. A. Broersen Shufan Huo Shufan Huo Sophie K. Piper Peter U. Heuschmann Matthias Endres Matthias Endres Matthias Endres Matthias Endres Matthias Endres Bob Siegerink Bob Siegerink Thomas G. Liman Thomas G. Liman Thomas G. Liman Thomas G. Liman Low ankle-brachial index and cognitive function after stroke—the PROSpective with Incident Stroke Berlin (PROSCIS-B) Frontiers in Neurology ankle-brachial index ischemic stroke outcome post stroke cognitive function atherosclerosis |
| title | Low ankle-brachial index and cognitive function after stroke—the PROSpective with Incident Stroke Berlin (PROSCIS-B) |
| title_full | Low ankle-brachial index and cognitive function after stroke—the PROSpective with Incident Stroke Berlin (PROSCIS-B) |
| title_fullStr | Low ankle-brachial index and cognitive function after stroke—the PROSpective with Incident Stroke Berlin (PROSCIS-B) |
| title_full_unstemmed | Low ankle-brachial index and cognitive function after stroke—the PROSpective with Incident Stroke Berlin (PROSCIS-B) |
| title_short | Low ankle-brachial index and cognitive function after stroke—the PROSpective with Incident Stroke Berlin (PROSCIS-B) |
| title_sort | low ankle brachial index and cognitive function after stroke the prospective with incident stroke berlin proscis b |
| topic | ankle-brachial index ischemic stroke outcome post stroke cognitive function atherosclerosis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.963262/full |
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