Computer-Assisted Design of Peptide-Based Radiotracers
In medical imaging, techniques such as magnetic resonance imaging, contrast-enhanced computerized tomography, positron emission tomography (PET), and single-photon emission computed tomography (SPECT) are extensively available and routinely used for disease diagnosis. PET probes with peptide-based t...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/7/6856 |
| _version_ | 1797607625229074432 |
|---|---|
| author | Vincenzo Patamia Chiara Zagni Ilaria Brullo Erika Saccullo Alessandro Coco Giuseppe Floresta Antonio Rescifina |
| author_facet | Vincenzo Patamia Chiara Zagni Ilaria Brullo Erika Saccullo Alessandro Coco Giuseppe Floresta Antonio Rescifina |
| author_sort | Vincenzo Patamia |
| collection | DOAJ |
| description | In medical imaging, techniques such as magnetic resonance imaging, contrast-enhanced computerized tomography, positron emission tomography (PET), and single-photon emission computed tomography (SPECT) are extensively available and routinely used for disease diagnosis. PET probes with peptide-based targeting are typically composed of small peptides especially developed to have high affinity and specificity for a range of cellular and tissue targets. These probes’ key benefits include being less expensive than traditional antibody-based PET tracers and having an effective chemical modification process that allows them to be radiolabeled with almost any radionuclide, making them highly appealing for clinical usage. Currently, as with every pharmaceutical design, the use of in silico strategies is steadily growing in this field, even though it is not part of the standard toolkit used during radiopharmaceutical design. This review describes the recent applications of computational design approaches in the design of novel peptide-based radiopharmaceuticals. |
| first_indexed | 2024-03-11T05:33:27Z |
| format | Article |
| id | doaj.art-1a32712b230543a88a2372c0fe82d391 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T05:33:27Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1a32712b230543a88a2372c0fe82d3912023-11-17T16:57:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01247685610.3390/ijms24076856Computer-Assisted Design of Peptide-Based RadiotracersVincenzo Patamia0Chiara Zagni1Ilaria Brullo2Erika Saccullo3Alessandro Coco4Giuseppe Floresta5Antonio Rescifina6Dipartimento di Scienze del Farmaco e della Salute, Università di Catania, Viale A. Doria 6, 95125 Catania, ItalyDipartimento di Scienze del Farmaco e della Salute, Università di Catania, Viale A. Doria 6, 95125 Catania, ItalyDipartimento di Scienze del Farmaco e della Salute, Università di Catania, Viale A. Doria 6, 95125 Catania, ItalyDipartimento di Scienze del Farmaco e della Salute, Università di Catania, Viale A. Doria 6, 95125 Catania, ItalyDipartimento di Scienze del Farmaco e della Salute, Università di Catania, Viale A. Doria 6, 95125 Catania, ItalyDipartimento di Scienze del Farmaco e della Salute, Università di Catania, Viale A. Doria 6, 95125 Catania, ItalyDipartimento di Scienze del Farmaco e della Salute, Università di Catania, Viale A. Doria 6, 95125 Catania, ItalyIn medical imaging, techniques such as magnetic resonance imaging, contrast-enhanced computerized tomography, positron emission tomography (PET), and single-photon emission computed tomography (SPECT) are extensively available and routinely used for disease diagnosis. PET probes with peptide-based targeting are typically composed of small peptides especially developed to have high affinity and specificity for a range of cellular and tissue targets. These probes’ key benefits include being less expensive than traditional antibody-based PET tracers and having an effective chemical modification process that allows them to be radiolabeled with almost any radionuclide, making them highly appealing for clinical usage. Currently, as with every pharmaceutical design, the use of in silico strategies is steadily growing in this field, even though it is not part of the standard toolkit used during radiopharmaceutical design. This review describes the recent applications of computational design approaches in the design of novel peptide-based radiopharmaceuticals.https://www.mdpi.com/1422-0067/24/7/6856imagingnuclear medicinepeptide probescomputer-assisted molecular designCADD |
| spellingShingle | Vincenzo Patamia Chiara Zagni Ilaria Brullo Erika Saccullo Alessandro Coco Giuseppe Floresta Antonio Rescifina Computer-Assisted Design of Peptide-Based Radiotracers International Journal of Molecular Sciences imaging nuclear medicine peptide probes computer-assisted molecular design CADD |
| title | Computer-Assisted Design of Peptide-Based Radiotracers |
| title_full | Computer-Assisted Design of Peptide-Based Radiotracers |
| title_fullStr | Computer-Assisted Design of Peptide-Based Radiotracers |
| title_full_unstemmed | Computer-Assisted Design of Peptide-Based Radiotracers |
| title_short | Computer-Assisted Design of Peptide-Based Radiotracers |
| title_sort | computer assisted design of peptide based radiotracers |
| topic | imaging nuclear medicine peptide probes computer-assisted molecular design CADD |
| url | https://www.mdpi.com/1422-0067/24/7/6856 |
| work_keys_str_mv | AT vincenzopatamia computerassisteddesignofpeptidebasedradiotracers AT chiarazagni computerassisteddesignofpeptidebasedradiotracers AT ilariabrullo computerassisteddesignofpeptidebasedradiotracers AT erikasaccullo computerassisteddesignofpeptidebasedradiotracers AT alessandrococo computerassisteddesignofpeptidebasedradiotracers AT giuseppefloresta computerassisteddesignofpeptidebasedradiotracers AT antoniorescifina computerassisteddesignofpeptidebasedradiotracers |