Nono‐titanium dioxide exposure during the adolescent period induces neurotoxicities in rats: Ameliorative potential of bergamot essential oil
Abstract Introduction In adolescence, the brain is still maturing, and disorders in maturation may affect the normal development of the brain. Exposure to titanium dioxide nanoparticles (TiO2 NPs) has various potential negative effects on the central nervous system. Bergamot essential oil (BEO) has...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-05-01
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| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.2099 |
| _version_ | 1818613014706782208 |
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| author | Yonghua Cui Yi Che Hongxin Wang |
| author_facet | Yonghua Cui Yi Che Hongxin Wang |
| author_sort | Yonghua Cui |
| collection | DOAJ |
| description | Abstract Introduction In adolescence, the brain is still maturing, and disorders in maturation may affect the normal development of the brain. Exposure to titanium dioxide nanoparticles (TiO2 NPs) has various potential negative effects on the central nervous system. Bergamot essential oil (BEO) has been found to be effective for neuroprotection. Methods The rats were injected intraperitoneally with TiO2 NPs (20 mg/kg) and/or BEO (200 mg/kg). The endogenous antioxidant state and inflammatory parameters were estimated using ELISA kits, and then the memory ability and anxiety‐like behavior in rats were assessed. Results TiO2 NPs exposure during the adolescent period induced anxiety‐like behavior, cognitive impairment, neuroinflammation and oxidative damage in hippocampus, and BEO treatment could significantly ameliorate the neurotoxicities induced by TiO2 NPs exposure. Conclusion Our results suggest that the negative effects of TiO2 NPs exposure during the adolescent period on anxiety‐like behavior and cognitive function may be related to oxidative stress and neuroinflammation induced by TiO2 NPs exposure. In addition, BEO may ameliorate the neurotoxicities induced by TiO2 NPs exposure in adolescent rats through the antioxidant and anti‐inflammatory activity of BEO. |
| first_indexed | 2024-12-16T15:55:23Z |
| format | Article |
| id | doaj.art-1a32e33f8142456d8b5224c603630fa8 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-16T15:55:23Z |
| publishDate | 2021-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-1a32e33f8142456d8b5224c603630fa82022-12-21T22:25:36ZengWileyBrain and Behavior2162-32792021-05-01115n/an/a10.1002/brb3.2099Nono‐titanium dioxide exposure during the adolescent period induces neurotoxicities in rats: Ameliorative potential of bergamot essential oilYonghua Cui0Yi Che1Hongxin Wang2State Key Laboratory of Food Science and Technology Jiangnan University Wuxi ChinaMedical College Soochow University Suzhou ChinaState Key Laboratory of Food Science and Technology Jiangnan University Wuxi ChinaAbstract Introduction In adolescence, the brain is still maturing, and disorders in maturation may affect the normal development of the brain. Exposure to titanium dioxide nanoparticles (TiO2 NPs) has various potential negative effects on the central nervous system. Bergamot essential oil (BEO) has been found to be effective for neuroprotection. Methods The rats were injected intraperitoneally with TiO2 NPs (20 mg/kg) and/or BEO (200 mg/kg). The endogenous antioxidant state and inflammatory parameters were estimated using ELISA kits, and then the memory ability and anxiety‐like behavior in rats were assessed. Results TiO2 NPs exposure during the adolescent period induced anxiety‐like behavior, cognitive impairment, neuroinflammation and oxidative damage in hippocampus, and BEO treatment could significantly ameliorate the neurotoxicities induced by TiO2 NPs exposure. Conclusion Our results suggest that the negative effects of TiO2 NPs exposure during the adolescent period on anxiety‐like behavior and cognitive function may be related to oxidative stress and neuroinflammation induced by TiO2 NPs exposure. In addition, BEO may ameliorate the neurotoxicities induced by TiO2 NPs exposure in adolescent rats through the antioxidant and anti‐inflammatory activity of BEO.https://doi.org/10.1002/brb3.2099anxietybergamot essential oilmemoryNano‐titanium dioxideneurotoxicity |
| spellingShingle | Yonghua Cui Yi Che Hongxin Wang Nono‐titanium dioxide exposure during the adolescent period induces neurotoxicities in rats: Ameliorative potential of bergamot essential oil Brain and Behavior anxiety bergamot essential oil memory Nano‐titanium dioxide neurotoxicity |
| title | Nono‐titanium dioxide exposure during the adolescent period induces neurotoxicities in rats: Ameliorative potential of bergamot essential oil |
| title_full | Nono‐titanium dioxide exposure during the adolescent period induces neurotoxicities in rats: Ameliorative potential of bergamot essential oil |
| title_fullStr | Nono‐titanium dioxide exposure during the adolescent period induces neurotoxicities in rats: Ameliorative potential of bergamot essential oil |
| title_full_unstemmed | Nono‐titanium dioxide exposure during the adolescent period induces neurotoxicities in rats: Ameliorative potential of bergamot essential oil |
| title_short | Nono‐titanium dioxide exposure during the adolescent period induces neurotoxicities in rats: Ameliorative potential of bergamot essential oil |
| title_sort | nono titanium dioxide exposure during the adolescent period induces neurotoxicities in rats ameliorative potential of bergamot essential oil |
| topic | anxiety bergamot essential oil memory Nano‐titanium dioxide neurotoxicity |
| url | https://doi.org/10.1002/brb3.2099 |
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