Determination of the Expression of CD69 Marker of Early Activation in the Immune Mice Lymphocytes after their Stimulation with Plague Agent Antigens
Evaluated was the ability of plague microbe antigens F1 and V to activate specifically in the in vitro system subpopulations of T-lymphocytes of BALB/c mice immunized against plague. The level of CD69 expression at the lymphocytes surface was proposed to be evaluated as the marker of lymphocytes act...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2010-02-01
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| Series: | Проблемы особо опасных инфекций |
| Subjects: | |
| Online Access: | https://journal.microbe.ru/jour/article/view/510 |
| _version_ | 1826922487198253056 |
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| author | V. V. Firstova I. V. Bakhteeva G. M. Titareva E. V. Zyrina S. A. Ivanov N. V. Kisseleva P. Kh. Kopylov A. P. Anisimov I. A. Dyatlov |
| author_facet | V. V. Firstova I. V. Bakhteeva G. M. Titareva E. V. Zyrina S. A. Ivanov N. V. Kisseleva P. Kh. Kopylov A. P. Anisimov I. A. Dyatlov |
| author_sort | V. V. Firstova |
| collection | DOAJ |
| description | Evaluated was the ability of plague microbe antigens F1 and V to activate specifically in the in vitro system subpopulations of T-lymphocytes of BALB/c mice immunized against plague. The level of CD69 expression at the lymphocytes surface was proposed to be evaluated as the marker of lymphocytes activation. Expression of CD69 early marker of activation in subpopulations of T-helpers and cytotoxic lymphocytes, reciprocated by the in vitro stimulation with Y. pestis F1, correlated with the intensity of the anti-plague postvaccinal immunity induced by immunization with F1 or F1and V antigens mixtures. |
| first_indexed | 2024-03-08T13:45:06Z |
| format | Article |
| id | doaj.art-1a3372c03ea34898aa7bdada8309709a |
| institution | Directory Open Access Journal |
| issn | 0370-1069 2658-719X |
| language | Russian |
| last_indexed | 2025-02-17T14:10:31Z |
| publishDate | 2010-02-01 |
| publisher | Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” |
| record_format | Article |
| series | Проблемы особо опасных инфекций |
| spelling | doaj.art-1a3372c03ea34898aa7bdada8309709a2024-12-24T12:09:47ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2010-02-0101(103)565910.21055/0370-1069-2010-1(103)-56-59494Determination of the Expression of CD69 Marker of Early Activation in the Immune Mice Lymphocytes after their Stimulation with Plague Agent AntigensV. V. Firstova0I. V. Bakhteeva1G. M. Titareva2E. V. Zyrina3S. A. Ivanov4N. V. Kisseleva5P. Kh. Kopylov6A. P. Anisimov7I. A. Dyatlov8State Research Center for Applied Microbiology and BiotechnologyState Research Center for Applied Microbiology and BiotechnologyState Research Center for Applied Microbiology and BiotechnologyState Research Center for Applied Microbiology and BiotechnologyState Research Center for Applied Microbiology and BiotechnologyState Research Center for Applied Microbiology and BiotechnologyState Research Center for Applied Microbiology and BiotechnologyState Research Center for Applied Microbiology and BiotechnologyState Research Center for Applied Microbiology and BiotechnologyEvaluated was the ability of plague microbe antigens F1 and V to activate specifically in the in vitro system subpopulations of T-lymphocytes of BALB/c mice immunized against plague. The level of CD69 expression at the lymphocytes surface was proposed to be evaluated as the marker of lymphocytes activation. Expression of CD69 early marker of activation in subpopulations of T-helpers and cytotoxic lymphocytes, reciprocated by the in vitro stimulation with Y. pestis F1, correlated with the intensity of the anti-plague postvaccinal immunity induced by immunization with F1 or F1and V antigens mixtures.https://journal.microbe.ru/jour/article/view/510plaguepostvaccinal immunitycd69 marker |
| spellingShingle | V. V. Firstova I. V. Bakhteeva G. M. Titareva E. V. Zyrina S. A. Ivanov N. V. Kisseleva P. Kh. Kopylov A. P. Anisimov I. A. Dyatlov Determination of the Expression of CD69 Marker of Early Activation in the Immune Mice Lymphocytes after their Stimulation with Plague Agent Antigens Проблемы особо опасных инфекций plague postvaccinal immunity cd69 marker |
| title | Determination of the Expression of CD69 Marker of Early Activation in the Immune Mice Lymphocytes after their Stimulation with Plague Agent Antigens |
| title_full | Determination of the Expression of CD69 Marker of Early Activation in the Immune Mice Lymphocytes after their Stimulation with Plague Agent Antigens |
| title_fullStr | Determination of the Expression of CD69 Marker of Early Activation in the Immune Mice Lymphocytes after their Stimulation with Plague Agent Antigens |
| title_full_unstemmed | Determination of the Expression of CD69 Marker of Early Activation in the Immune Mice Lymphocytes after their Stimulation with Plague Agent Antigens |
| title_short | Determination of the Expression of CD69 Marker of Early Activation in the Immune Mice Lymphocytes after their Stimulation with Plague Agent Antigens |
| title_sort | determination of the expression of cd69 marker of early activation in the immune mice lymphocytes after their stimulation with plague agent antigens |
| topic | plague postvaccinal immunity cd69 marker |
| url | https://journal.microbe.ru/jour/article/view/510 |
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