Frailty-Preventing Effect of an Intervention Program Using a Novel Complete Nutritional “COMB-FP Meal”: A Pilot Randomized Control Trial
Frailty is a huge concern for the aging population, and dietary nutrition is considered a key factor in the prevention of aging. To solve the problem of frailty in the aging population, we developed a novel dietary intervention program using a novel COMpletely Balanced for Frailty Prevention (COMB-F...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/20/4317 |
| _version_ | 1797572699531247616 |
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| author | Takuo Nakazeko Naohisa Shobako Nobuhiko Shioya Yoshitaka Iwama Yukio Hirano Shintaro Fujii Futoshi Nakamura Keiko Honda |
| author_facet | Takuo Nakazeko Naohisa Shobako Nobuhiko Shioya Yoshitaka Iwama Yukio Hirano Shintaro Fujii Futoshi Nakamura Keiko Honda |
| author_sort | Takuo Nakazeko |
| collection | DOAJ |
| description | Frailty is a huge concern for the aging population, and dietary nutrition is considered a key factor in the prevention of aging. To solve the problem of frailty in the aging population, we developed a novel dietary intervention program using a novel COMpletely Balanced for Frailty Prevention (COMB-FP) meal, based on the Dietary Reference Intake for Japanese; in addition, we conducted a pilot randomized control trial comparing an exercise program only (control group) with exercise plus the COMB-FP meal program (test group). We included 110 male and female healthy volunteers with pre-frailty or frailty; the trial lasted for 12 weeks. Two daily meals were replaced with the COMB-FP meals during the trial in the test group. Walking speed and cognitive function were significantly improved in the test group compared with the control group. We observed a similar pattern in other frailty-related outcomes, such as occupancy of the microbiome, World Health Organization well-being index (WHO-5), and oxidative stress. Our study might indicate the importance of a well-balanced intake of nutrients for frailty prevention. |
| first_indexed | 2024-03-10T20:59:19Z |
| format | Article |
| id | doaj.art-1a33a9ae9fa8465ea37044488ad65186 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T20:59:19Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-1a33a9ae9fa8465ea37044488ad651862023-11-19T17:36:59ZengMDPI AGNutrients2072-66432023-10-011520431710.3390/nu15204317Frailty-Preventing Effect of an Intervention Program Using a Novel Complete Nutritional “COMB-FP Meal”: A Pilot Randomized Control TrialTakuo Nakazeko0Naohisa Shobako1Nobuhiko Shioya2Yoshitaka Iwama3Yukio Hirano4Shintaro Fujii5Futoshi Nakamura6Keiko Honda7Future Food Research & Development Division, Nissin Foods Holdings Co., Ltd., Tokyo 192-0001, JapanFuture Food Research & Development Division, Nissin Foods Holdings Co., Ltd., Tokyo 192-0001, JapanKSO Corporation, Tokyo 105-002, JapanNihonbashi Cardiology Clinic, Tokyo 103-001, JapanFuture Food Research & Development Division, Nissin Foods Holdings Co., Ltd., Tokyo 192-0001, JapanFuture Food Research & Development Division, Nissin Foods Holdings Co., Ltd., Tokyo 192-0001, JapanFuture Food Research & Development Division, Nissin Foods Holdings Co., Ltd., Tokyo 192-0001, JapanLaboratory of Medicine Nutrition, Kagawa Nutrition University, Saitama 350-0214, JapanFrailty is a huge concern for the aging population, and dietary nutrition is considered a key factor in the prevention of aging. To solve the problem of frailty in the aging population, we developed a novel dietary intervention program using a novel COMpletely Balanced for Frailty Prevention (COMB-FP) meal, based on the Dietary Reference Intake for Japanese; in addition, we conducted a pilot randomized control trial comparing an exercise program only (control group) with exercise plus the COMB-FP meal program (test group). We included 110 male and female healthy volunteers with pre-frailty or frailty; the trial lasted for 12 weeks. Two daily meals were replaced with the COMB-FP meals during the trial in the test group. Walking speed and cognitive function were significantly improved in the test group compared with the control group. We observed a similar pattern in other frailty-related outcomes, such as occupancy of the microbiome, World Health Organization well-being index (WHO-5), and oxidative stress. Our study might indicate the importance of a well-balanced intake of nutrients for frailty prevention.https://www.mdpi.com/2072-6643/15/20/4317randomized control trialfrailtydiet treatmentcomplete nutrition |
| spellingShingle | Takuo Nakazeko Naohisa Shobako Nobuhiko Shioya Yoshitaka Iwama Yukio Hirano Shintaro Fujii Futoshi Nakamura Keiko Honda Frailty-Preventing Effect of an Intervention Program Using a Novel Complete Nutritional “COMB-FP Meal”: A Pilot Randomized Control Trial Nutrients randomized control trial frailty diet treatment complete nutrition |
| title | Frailty-Preventing Effect of an Intervention Program Using a Novel Complete Nutritional “COMB-FP Meal”: A Pilot Randomized Control Trial |
| title_full | Frailty-Preventing Effect of an Intervention Program Using a Novel Complete Nutritional “COMB-FP Meal”: A Pilot Randomized Control Trial |
| title_fullStr | Frailty-Preventing Effect of an Intervention Program Using a Novel Complete Nutritional “COMB-FP Meal”: A Pilot Randomized Control Trial |
| title_full_unstemmed | Frailty-Preventing Effect of an Intervention Program Using a Novel Complete Nutritional “COMB-FP Meal”: A Pilot Randomized Control Trial |
| title_short | Frailty-Preventing Effect of an Intervention Program Using a Novel Complete Nutritional “COMB-FP Meal”: A Pilot Randomized Control Trial |
| title_sort | frailty preventing effect of an intervention program using a novel complete nutritional comb fp meal a pilot randomized control trial |
| topic | randomized control trial frailty diet treatment complete nutrition |
| url | https://www.mdpi.com/2072-6643/15/20/4317 |
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