Plasticity of Scarpa’s ganglion neurons as a possible basis for functional restoration within vestibular endorgans

In a previous study (Brugeaud et al., 2007), we observed spontaneous restoration of the vestibular function in young adult rodents following excitotoxic injury of the neuronal network of vestibular endorgans. The functional restoration was supported by a repair of synaptic contacts between hair cell...

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Main Authors: Cécile eTravo, Sophie eGaboyard-Niay, Christian eChabbert
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-06-01
Series:Frontiers in Neurology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2012.00091/full
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author Cécile eTravo
Sophie eGaboyard-Niay
Sophie eGaboyard-Niay
Christian eChabbert
Christian eChabbert
author_facet Cécile eTravo
Sophie eGaboyard-Niay
Sophie eGaboyard-Niay
Christian eChabbert
Christian eChabbert
author_sort Cécile eTravo
collection DOAJ
description In a previous study (Brugeaud et al., 2007), we observed spontaneous restoration of the vestibular function in young adult rodents following excitotoxic injury of the neuronal network of vestibular endorgans. The functional restoration was supported by a repair of synaptic contacts between hair cells and primary vestibular neurons. This process was observed in 2/3 of the animals studied and occurred within five days following the synapse insult. To assess whether structural plasticity is a fundamental trait of altered vestibular endorgans and to decipher the cellular mechanisms that support such a repair process, we studied the neuronal regeneration and synaptogenesis in co-cultures of vestibular epithelia and Scarpa’s ganglion from young and adult rodents. We demonstrate that under specific culture conditions, primary vestibular neurons from young mice or rats exhibit robust ability to regenerate nervous processes. When co-cultured with vestibular epithelia, primary vestibular neurons were able to establish de novo contacts with hair cells. Under the present paradigm, these contacts displayed morphological features of immature synaptic contacts. This reparative capacity remained in older mice although to a lesser extent. Identifying the basic mechanisms underlying the repair process may provide a basis for novel therapeutic strategies to restore mature and functional vestibular synaptic contacts following damage or loss.
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spelling doaj.art-1a369606aec34224bc44e2313feda24d2022-12-22T00:02:46ZengFrontiers Media S.A.Frontiers in Neurology1664-22952012-06-01310.3389/fneur.2012.0009120258Plasticity of Scarpa’s ganglion neurons as a possible basis for functional restoration within vestibular endorgansCécile eTravo0Sophie eGaboyard-Niay1Sophie eGaboyard-Niay2Christian eChabbert3Christian eChabbert4INSERMINSERMSensorionINSERMSensorionIn a previous study (Brugeaud et al., 2007), we observed spontaneous restoration of the vestibular function in young adult rodents following excitotoxic injury of the neuronal network of vestibular endorgans. The functional restoration was supported by a repair of synaptic contacts between hair cells and primary vestibular neurons. This process was observed in 2/3 of the animals studied and occurred within five days following the synapse insult. To assess whether structural plasticity is a fundamental trait of altered vestibular endorgans and to decipher the cellular mechanisms that support such a repair process, we studied the neuronal regeneration and synaptogenesis in co-cultures of vestibular epithelia and Scarpa’s ganglion from young and adult rodents. We demonstrate that under specific culture conditions, primary vestibular neurons from young mice or rats exhibit robust ability to regenerate nervous processes. When co-cultured with vestibular epithelia, primary vestibular neurons were able to establish de novo contacts with hair cells. Under the present paradigm, these contacts displayed morphological features of immature synaptic contacts. This reparative capacity remained in older mice although to a lesser extent. Identifying the basic mechanisms underlying the repair process may provide a basis for novel therapeutic strategies to restore mature and functional vestibular synaptic contacts following damage or loss.http://journal.frontiersin.org/Journal/10.3389/fneur.2012.00091/fullplasticityVestibuleprimary neuronssensory epitheliasynapserepair
spellingShingle Cécile eTravo
Sophie eGaboyard-Niay
Sophie eGaboyard-Niay
Christian eChabbert
Christian eChabbert
Plasticity of Scarpa’s ganglion neurons as a possible basis for functional restoration within vestibular endorgans
Frontiers in Neurology
plasticity
Vestibule
primary neurons
sensory epithelia
synapse
repair
title Plasticity of Scarpa’s ganglion neurons as a possible basis for functional restoration within vestibular endorgans
title_full Plasticity of Scarpa’s ganglion neurons as a possible basis for functional restoration within vestibular endorgans
title_fullStr Plasticity of Scarpa’s ganglion neurons as a possible basis for functional restoration within vestibular endorgans
title_full_unstemmed Plasticity of Scarpa’s ganglion neurons as a possible basis for functional restoration within vestibular endorgans
title_short Plasticity of Scarpa’s ganglion neurons as a possible basis for functional restoration within vestibular endorgans
title_sort plasticity of scarpa s ganglion neurons as a possible basis for functional restoration within vestibular endorgans
topic plasticity
Vestibule
primary neurons
sensory epithelia
synapse
repair
url http://journal.frontiersin.org/Journal/10.3389/fneur.2012.00091/full
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